DegronMD - Q6P996(PDXDC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S693L	TCGA-58-8387	LUSC	TCGA	LPPTPSGS	DEG_SCF_FBW7_1	688:695	Mutation altering degron motif	0.6556
p.R696H	TCGA-B5-A11E	UCEC	TCGA	LPPTPSGS	DEG_SCF_FBW7_1	688:695	Mutation rewiring degron network	0.3056
p.R696H	ACH-000999	Colon/Colorectal Cancer	CCLE	LPPTPSGS	DEG_SCF_FBW7_1	688:695	Mutation rewiring degron network	0.3056
p.R696H	SNU-1040	large intestine	COSMIC	LPPTPSGS	DEG_SCF_FBW7_1	688:695	Mutation rewiring degron network	0.3056
p.R788S	TCGA-B5-A3FA	UCEC	TCGA	SLR	DEG_APCC_TPR_1	786:788	Mutation altering degron motif	0.7427
p.Q682R	TCGA-CJ-6028	KIRC	TCGA	LPPTPSGS	DEG_SCF_FBW7_1	688:695	Mutation rewiring degron network	0.1667
p.K705T	TCGA-E6-A1M0	UCEC	TCGA	LPPTPSGS	DEG_SCF_FBW7_1	688:695	Mutation blocking ubiquitination signal	0.5
p.T687R	TCGA-XF-A9SZ	BLCA	TCGA	LPPTPSGS	DEG_SCF_FBW7_1	688:695	Mutation blocking phosphorylation signal	0.75
p.H698D	DO219046	BLCA	ICGC	LPPTPSGS	DEG_SCF_FBW7_1	688:695	Mutation substituting flanking lysine	0.3611
p.D701Y	DO13863	GBM	ICGC	LPPTPSGS	DEG_SCF_FBW7_1	688:695	Mutation rewiring degron network	0.1667
p.S691G	DO219717	KIRP	ICGC	LPPTPSGS	DEG_SCF_FBW7_1	688:695	Mutation altering degron motif	0.6993
p.K678N	DO227531	PACA	ICGC	LPPTPSGS	DEG_SCF_FBW7_1	688:695	Mutation rewiring degron network	0.0556
p.I699T	DO35606	PBCA	ICGC	LPPTPSGS	DEG_SCF_FBW7_1	688:695	Mutation rewiring degron network	0.2222
p.K678T	DO43682	UCEC	ICGC	LPPTPSGS	DEG_SCF_FBW7_1	688:695	Mutation rewiring degron network	0.0556
p.L702S	DO41823	UCEC	ICGC	LPPTPSGS	DEG_SCF_FBW7_1	688:695	Mutation rewiring degron network	0.1389
p.T687M	SIDM00529	Breast Carcinoma	GDSC	LPPTPSGS	DEG_SCF_FBW7_1	688:695	Mutation blocking phosphorylation signal	0.75
p.T687M	MDA-MB-157	breast	COSMIC	LPPTPSGS	DEG_SCF_FBW7_1	688:695	Mutation blocking phosphorylation signal	0.75
p.P784L	SIDM01409	Bladder Carcinoma	GDSC	SLR	DEG_APCC_TPR_1	786:788	Mutation rewiring degron network	0.2778
p.E793D	VCaP	prostate	COSMIC	SLR	DEG_APCC_TPR_1	786:788	Mutation rewiring degron network	0.1944
p.E705Q	H2803	pleura	COSMIC	LPPTPSGS	DEG_SCF_FBW7_1	688:695	Mutation blocking ubiquitination signal	0.5
p.E684D	VCaP	prostate	COSMIC	LPPTPSGS	DEG_SCF_FBW7_1	688:695	Mutation rewiring degron network	0.2222
p.A685T	HCC1569	breast	COSMIC	LPPTPSGS	DEG_SCF_FBW7_1	688:695	Mutation rewiring degron network	0.25
p.D780N	IGR-1	skin	COSMIC	SLR	DEG_APCC_TPR_1	786:788	Mutation rewiring degron network	0.1667
p.Q781R	NCI-H660	prostate	COSMIC	SLR	DEG_APCC_TPR_1	786:788	Mutation rewiring degron network	0.1944
p.P776R	LS-123	large intestine	COSMIC	SLR	DEG_APCC_TPR_1	786:788	Mutation rewiring degron network	0.0556
p.T705M	MDA-MB-157	breast	COSMIC	LPPTPSGS	DEG_SCF_FBW7_1	688:695	Mutation blocking ubiquitination signal	0.5
p.S690T	CL-34	large intestine	COSMIC	LPPTPSGS	DEG_SCF_FBW7_1	688:695	Mutation altering degron motif	0.7116
p.S691T	CL-34	large intestine	COSMIC	LPPTPSGS	DEG_SCF_FBW7_1	688:695	Mutation altering degron motif	0.7116

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PDXDC1

UniProt ID: Q6P996

Entrez ID: 23042

Protein name: Pyridoxal-dependent decarboxylase domain-containing protein 1 (EC 4.1.1.-)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PDXDC1 in