DegronMD

Uniprot ID: Q6P996

Source protein: Pyridoxal-dependent decarboxylase domain-containing protein 1

Source gene: PDXDC1

Class: DEG_APCC_TPR_1

Location: 786:788

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9326

ASA_SCORE: 106.2333

COIL: 0.63

CONS_SCORE: 0.2671

DSS_SCORE: 0.9939

HELIX: 0.3453

FCONS_SCORE: 1.0541

RIG_SCORE: 0.6571

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R788S	TCGA-B5-A3FA	UCEC	TCGA	SLR	DEG_APCC_TPR_1	0.7427
p.P784L	SIDM01409	Bladder Carcinoma	GDSC	SLR	DEG_APCC_TPR_1	0.2778
p.E793D	VCaP	prostate	COSMIC	SLR	DEG_APCC_TPR_1	0.1944
p.D780N	IGR-1	skin	COSMIC	SLR	DEG_APCC_TPR_1	0.1667
p.Q781R	NCI-H660	prostate	COSMIC	SLR	DEG_APCC_TPR_1	0.1944
p.P776R	LS-123	large_intestine	COSMIC	SLR	DEG_APCC_TPR_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0JLT2	Mediator of RNA polymerase II transcription subunit 19	DEG_APCC_TPR_1	242:244	SLR	APC,CDC20,FZR1	0.9687	More...
P33076	MHC class II transactivator	DEG_APCC_TPR_1	1128:1130	SLR	APC,CDC20,FZR1	0.5639	More...
Q5TB30	DEP domain-containing protein 1A	DEG_APCC_TPR_1	809:811	SLR	APC,CDC20,FZR1	0.9983	More...
Q9UPV9	Trafficking kinesin-binding protein 1	DEG_APCC_TPR_1	951:953	SLR	APC,CDC20,FZR1	0.6844	More...
Q6P996	Pyridoxal-dependent decarboxylase domain-containing protein 1	DEG_APCC_TPR_1	786:788	SLR	APC,CDC20,FZR1	0.9326	More...
Q9BXG8	Spermatogenic leucine zipper protein 1	DEG_APCC_TPR_1	428:430	SLR	APC,CDC20,FZR1	0.9713	More...
Q9ULS6	Potassium voltage-gated channel subfamily S member 2	DEG_APCC_TPR_1	475:477	SLR	APC,CDC20,FZR1	0.8591	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons