DegronMD

Uniprot ID: Q9UPV9

Source protein: Trafficking kinesin-binding protein 1

Source gene: TRAK1

Class: DEG_APCC_TPR_1

Location: 951:953

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6844

ASA_SCORE: 126.6667

COIL: 0.864

CONS_SCORE: 0.2602

DSS_SCORE: 0.8889

HELIX: 0.095

FCONS_SCORE: 0.9794

RIG_SCORE: 0.7432

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K945T	TCGA-CD-A48C	STAD	TCGA	SLR	DEG_APCC_TPR_1	0.2778
p.K945T	DO47912	STAD	ICGC	SLR	DEG_APCC_TPR_1	0.2778
p.R953Q	DO1170	BRCA	ICGC	SLR	DEG_APCC_TPR_1	0.7329
p.A944S	DO229025	LICA	ICGC	SLR	DEG_APCC_TPR_1	0.1389
p.A944G	DO50884	LICA	ICGC	SLR	DEG_APCC_TPR_1	0.1389
p.K945Q	DO46468	OV	ICGC	SLR	DEG_APCC_TPR_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0JLT2	Mediator of RNA polymerase II transcription subunit 19	DEG_APCC_TPR_1	242:244	SLR	APC,CDC20,FZR1	0.9687	More...
P33076	MHC class II transactivator	DEG_APCC_TPR_1	1128:1130	SLR	APC,CDC20,FZR1	0.5639	More...
Q5TB30	DEP domain-containing protein 1A	DEG_APCC_TPR_1	809:811	SLR	APC,CDC20,FZR1	0.9983	More...
Q9UPV9	Trafficking kinesin-binding protein 1	DEG_APCC_TPR_1	951:953	SLR	APC,CDC20,FZR1	0.6844	More...
Q6P996	Pyridoxal-dependent decarboxylase domain-containing protein 1	DEG_APCC_TPR_1	786:788	SLR	APC,CDC20,FZR1	0.9326	More...
Q9BXG8	Spermatogenic leucine zipper protein 1	DEG_APCC_TPR_1	428:430	SLR	APC,CDC20,FZR1	0.9713	More...
Q9ULS6	Potassium voltage-gated channel subfamily S member 2	DEG_APCC_TPR_1	475:477	SLR	APC,CDC20,FZR1	0.8591	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons