DegronMD

Uniprot ID: Q5TB30

Source protein: DEP domain-containing protein 1A

Source gene: DEPDC1

Class: DEG_APCC_TPR_1

Location: 809:811

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9983

ASA_SCORE: 130.5667

COIL: 0.914

CONS_SCORE: 0.3918

DSS_SCORE: 0.8057

HELIX: 0.08

FCONS_SCORE: 1.3198

RIG_SCORE: 0.7512

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K806E	SIDM00841	Colorectal Carcinoma	GDSC	SLR	DEG_APCC_TPR_1	0.3611
p.K806E	ACH-000651	Colon/Colorectal Cancer	CCLE	SLR	DEG_APCC_TPR_1	0.3611
p.K806E	ACH-000842	Colon/Colorectal Cancer	CCLE	SLR	DEG_APCC_TPR_1	0.3611
p.K806E	SW620	large_intestine	COSMIC	SLR	DEG_APCC_TPR_1	0.3611
p.L810P	ACH-001431	Bone Cancer	CCLE	SLR	DEG_APCC_TPR_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0JLT2	Mediator of RNA polymerase II transcription subunit 19	DEG_APCC_TPR_1	242:244	SLR	APC,CDC20,FZR1	0.9687	More...
P33076	MHC class II transactivator	DEG_APCC_TPR_1	1128:1130	SLR	APC,CDC20,FZR1	0.5639	More...
Q5TB30	DEP domain-containing protein 1A	DEG_APCC_TPR_1	809:811	SLR	APC,CDC20,FZR1	0.9983	More...
Q9UPV9	Trafficking kinesin-binding protein 1	DEG_APCC_TPR_1	951:953	SLR	APC,CDC20,FZR1	0.6844	More...
Q6P996	Pyridoxal-dependent decarboxylase domain-containing protein 1	DEG_APCC_TPR_1	786:788	SLR	APC,CDC20,FZR1	0.9326	More...
Q9BXG8	Spermatogenic leucine zipper protein 1	DEG_APCC_TPR_1	428:430	SLR	APC,CDC20,FZR1	0.9713	More...
Q9ULS6	Potassium voltage-gated channel subfamily S member 2	DEG_APCC_TPR_1	475:477	SLR	APC,CDC20,FZR1	0.8591	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons