DegronMD - Q5TB30(DEPDC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I163K	TCGA-AA-3715	COAD	TCGA	SQENGE	DEG_Kelch_Keap1_1	156:161	Mutation rewiring degron network	0.2778
p.I163K	DO8018	COAD	ICGC	SQENGE	DEG_Kelch_Keap1_1	156:161	Mutation rewiring degron network	0.2778
p.N537I	TCGA-CC-A9FU	LIHC	TCGA	INTPVAE	DEG_SCF_FBW7_2	525:531	Mutation rewiring degron network	0.1667
p.N537I	DO52190	LIHC	ICGC	INTPVAE	DEG_SCF_FBW7_2	525:531	Mutation rewiring degron network	0.1667
p.H165P	TCGA-CM-6674	COAD	TCGA	SQENGE	DEG_Kelch_Keap1_1	156:161	Mutation rewiring degron network	0.2222
p.H165P	DO10092	COAD	ICGC	SQENGE	DEG_Kelch_Keap1_1	156:161	Mutation rewiring degron network	0.2222
p.R150K	TCGA-EE-A2A2	SKCM	TCGA	SQENGE	DEG_Kelch_Keap1_1	156:161	Mutation rewiring degron network	0.1667
p.R150K	DO37583	SKCM	ICGC	SQENGE	DEG_Kelch_Keap1_1	156:161	Mutation rewiring degron network	0.1667
p.M534I	TCGA-MP-A4TK	LUAD	TCGA	INTPVAE	DEG_SCF_FBW7_2	525:531	Mutation rewiring degron network	0.25
p.M534I	DO45384	LUAD	ICGC	INTPVAE	DEG_SCF_FBW7_2	525:531	Mutation rewiring degron network	0.25
p.G152A	TCGA-R3-A69X	BLCA	TCGA	SQENGE	DEG_Kelch_Keap1_1	156:161	Mutation rewiring degron network	0.2222
p.G152A	DO51902	BLCA	ICGC	SQENGE	DEG_Kelch_Keap1_1	156:161	Mutation rewiring degron network	0.2222
p.E161K	DO233109	GACA	ICGC	SQENGE	DEG_Kelch_Keap1_1	156:161	Mutation altering degron motif	0.7022
p.H154N	DO229019	LICA	ICGC	SQENGE	DEG_Kelch_Keap1_1	156:161	Mutation rewiring degron network	0.2778
p.I163V	DO36556	READ	ICGC	SQENGE	DEG_Kelch_Keap1_1	156:161	Mutation rewiring degron network	0.2778
p.Y524C	DO229232	THCA	ICGC	INTPVAE	DEG_SCF_FBW7_2	525:531	Mutation rewiring degron network	0.3056
p.T527I	SIDM00789	Colorectal Carcinoma	GDSC	INTPVAE	DEG_SCF_FBW7_2	525:531	Mutation altering degron motif	0.7078
p.T527I	ACH-000997	Colon/Colorectal Cancer	CCLE	INTPVAE	DEG_SCF_FBW7_2	525:531	Mutation altering degron motif	0.7078
p.T527I	ACH-001061	Colon/Colorectal Cancer	CCLE	INTPVAE	DEG_SCF_FBW7_2	525:531	Mutation altering degron motif	0.7078
p.T527I	HCT-15	large intestine	COSMIC	INTPVAE	DEG_SCF_FBW7_2	525:531	Mutation altering degron motif	0.7078
p.G160V	SIDM00282	Colorectal Carcinoma	GDSC	SQENGE	DEG_Kelch_Keap1_1	156:161	Mutation altering degron motif	0.7532
p.K806E	SIDM00841	Colorectal Carcinoma	GDSC	SLR	DEG_APCC_TPR_1	809:811	Mutation substituting flanking lysine	0.3611
p.K806E	ACH-000651	Colon/Colorectal Cancer	CCLE	SLR	DEG_APCC_TPR_1	809:811	Mutation substituting flanking lysine	0.3611
p.K806E	ACH-000842	Colon/Colorectal Cancer	CCLE	SLR	DEG_APCC_TPR_1	809:811	Mutation substituting flanking lysine	0.3611
p.K806E	SW620	large intestine	COSMIC	SLR	DEG_APCC_TPR_1	809:811	Mutation substituting flanking lysine	0.3611
p.L810P	ACH-001431	Bone Cancer	CCLE	SLR	DEG_APCC_TPR_1	809:811	Mutation altering degron motif	0.7582
p.K522E	SW620	large intestine	COSMIC	INTPVAE	DEG_SCF_FBW7_2	525:531	Mutation rewiring degron network	0.25

Kaplan plot for DEPDC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DEPDC1

UniProt ID: Q5TB30

Entrez ID: 55635

Protein name: DEP domain-containing protein 1A

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DEPDC1 in