DegronMD

Uniprot ID: Q5TB30

Source protein: DEP domain-containing protein 1A

Source gene: DEPDC1

Class: DEG_Kelch_Keap1_1

Location: 156:161

E3 ligase: KEAP1

DEGRON score: 0.5612

ASA_SCORE: 95.6833

COIL: 0.7858

CONS_SCORE: 0.3449

DSS_SCORE: 0.5408

HELIX: 0.1365

FCONS_SCORE: 1.0445

RIG_SCORE: 0.621

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I163K	TCGA-AA-3715	COAD	TCGA	SQENGE	DEG_Kelch_Keap1_1	0.2778
p.I163K	DO8018	COAD	ICGC	SQENGE	DEG_Kelch_Keap1_1	0.2778
p.H165P	TCGA-CM-6674	COAD	TCGA	SQENGE	DEG_Kelch_Keap1_1	0.2222
p.H165P	DO10092	COAD	ICGC	SQENGE	DEG_Kelch_Keap1_1	0.2222
p.R150K	TCGA-EE-A2A2	SKCM	TCGA	SQENGE	DEG_Kelch_Keap1_1	0.1667
p.R150K	DO37583	SKCM	ICGC	SQENGE	DEG_Kelch_Keap1_1	0.1667
p.G152A	TCGA-R3-A69X	BLCA	TCGA	SQENGE	DEG_Kelch_Keap1_1	0.2222
p.G152A	DO51902	BLCA	ICGC	SQENGE	DEG_Kelch_Keap1_1	0.2222
p.E161K	DO233109	GACA	ICGC	SQENGE	DEG_Kelch_Keap1_1	0.7022
p.H154N	DO229019	LICA	ICGC	SQENGE	DEG_Kelch_Keap1_1	0.2778
p.I163V	DO36556	READ	ICGC	SQENGE	DEG_Kelch_Keap1_1	0.2778
p.G160V	SIDM00282	Colorectal Carcinoma	GDSC	SQENGE	DEG_Kelch_Keap1_1	0.7532

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TB30	DEP domain-containing protein 1A	DEG_Kelch_Keap1_1	156:161	SQENGE	KEAP1	0.5612	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons