DegronMD

Uniprot ID: Q5TB30

Source protein: DEP domain-containing protein 1A

Source gene: DEPDC1

Class: DEG_SCF_FBW7_2

Location: 525:531

E3 ligase: FBXW7

DEGRON score: 0.9159

ASA_SCORE: 75.0429

COIL: 0.6481

CONS_SCORE: 0.3544

DSS_SCORE: 0.407

HELIX: 0.0821

FCONS_SCORE: 1.1855

RIG_SCORE: 0.7992

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N537I	TCGA-CC-A9FU	LIHC	TCGA	INTPVAE	DEG_SCF_FBW7_2	0.1667
p.N537I	DO52190	LIHC	ICGC	INTPVAE	DEG_SCF_FBW7_2	0.1667
p.M534I	TCGA-MP-A4TK	LUAD	TCGA	INTPVAE	DEG_SCF_FBW7_2	0.25
p.M534I	DO45384	LUAD	ICGC	INTPVAE	DEG_SCF_FBW7_2	0.25
p.Y524C	DO229232	THCA	ICGC	INTPVAE	DEG_SCF_FBW7_2	0.3056
p.T527I	SIDM00789	Colorectal Carcinoma	GDSC	INTPVAE	DEG_SCF_FBW7_2	0.7078
p.T527I	ACH-000997	Colon/Colorectal Cancer	CCLE	INTPVAE	DEG_SCF_FBW7_2	0.7078
p.T527I	ACH-001061	Colon/Colorectal Cancer	CCLE	INTPVAE	DEG_SCF_FBW7_2	0.7078
p.T527I	HCT-15	large_intestine	COSMIC	INTPVAE	DEG_SCF_FBW7_2	0.7078
p.K522E	SW620	large_intestine	COSMIC	INTPVAE	DEG_SCF_FBW7_2	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TB30	DEP domain-containing protein 1A	DEG_SCF_FBW7_2	525:531	INTPVAE	FBXW7	0.9159	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons