DegronMD

Uniprot ID: Q6P996

Source protein: Pyridoxal-dependent decarboxylase domain-containing protein 1

Source gene: PDXDC1

Class: DEG_SCF_FBW7_1

Location: 688:695

E3 ligase: FBXW7

DEGRON score: 0.9859

ASA_SCORE: 86.8625

COIL: 0.9586

CONS_SCORE: 0.3086

DSS_SCORE: 0.6677

HELIX: 0.0136

FCONS_SCORE: 0.758

RIG_SCORE: 0.6343

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S693L	TCGA-58-8387	LUSC	TCGA	LPPTPSGS	DEG_SCF_FBW7_1	0.6556
p.R696H	TCGA-B5-A11E	UCEC	TCGA	LPPTPSGS	DEG_SCF_FBW7_1	0.3056
p.R696H	ACH-000999	Colon/Colorectal Cancer	CCLE	LPPTPSGS	DEG_SCF_FBW7_1	0.3056
p.R696H	SNU-1040	large_intestine	COSMIC	LPPTPSGS	DEG_SCF_FBW7_1	0.3056
p.Q682R	TCGA-CJ-6028	KIRC	TCGA	LPPTPSGS	DEG_SCF_FBW7_1	0.1667
p.K705T	TCGA-E6-A1M0	UCEC	TCGA	LPPTPSGS	DEG_SCF_FBW7_1	0.5
p.T687R	TCGA-XF-A9SZ	BLCA	TCGA	LPPTPSGS	DEG_SCF_FBW7_1	0.75
p.H698D	DO219046	BLCA	ICGC	LPPTPSGS	DEG_SCF_FBW7_1	0.3611
p.D701Y	DO13863	GBM	ICGC	LPPTPSGS	DEG_SCF_FBW7_1	0.1667
p.S691G	DO219717	KIRP	ICGC	LPPTPSGS	DEG_SCF_FBW7_1	0.6993
p.K678N	DO227531	PACA	ICGC	LPPTPSGS	DEG_SCF_FBW7_1	0.0556
p.I699T	DO35606	PBCA	ICGC	LPPTPSGS	DEG_SCF_FBW7_1	0.2222
p.K678T	DO43682	UCEC	ICGC	LPPTPSGS	DEG_SCF_FBW7_1	0.0556
p.L702S	DO41823	UCEC	ICGC	LPPTPSGS	DEG_SCF_FBW7_1	0.1389
p.T687M	SIDM00529	Breast Carcinoma	GDSC	LPPTPSGS	DEG_SCF_FBW7_1	0.75
p.T687M	MDA-MB-157	breast	COSMIC	LPPTPSGS	DEG_SCF_FBW7_1	0.75
p.E705Q	H2803	pleura	COSMIC	LPPTPSGS	DEG_SCF_FBW7_1	0.5
p.E684D	VCaP	prostate	COSMIC	LPPTPSGS	DEG_SCF_FBW7_1	0.2222
p.A685T	HCC1569	breast	COSMIC	LPPTPSGS	DEG_SCF_FBW7_1	0.25
p.T705M	MDA-MB-157	breast	COSMIC	LPPTPSGS	DEG_SCF_FBW7_1	0.5
p.S690T	CL-34	large_intestine	COSMIC	LPPTPSGS	DEG_SCF_FBW7_1	0.7116
p.S691T	CL-34	large_intestine	COSMIC	LPPTPSGS	DEG_SCF_FBW7_1	0.7116

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6P996	Pyridoxal-dependent decarboxylase domain-containing protein 1	DEG_SCF_FBW7_1	688:695	LPPTPSGS	FBXW7	0.9859	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons