DegronMD

Uniprot ID: Q9ULL1

Source protein: Pleckstrin homology domain-containing family G member 1

Source gene: PLEKHG1

Class: DEG_SPOP_SBC_1

Location: 61:65

E3 ligase: SPOP

DEGRON score: 0.9867

ASA_SCORE: 79.06

COIL: 0.8596

CONS_SCORE: 0.2972

DSS_SCORE: 0.5498

HELIX: 0.0822

FCONS_SCORE: 0.9465

RIG_SCORE: 0.6686

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A73T	TCGA-AA-3715	COAD	TCGA	PFSSS	DEG_SPOP_SBC_1	0.1111
p.A73T	DO8018	COAD	ICGC	PFSSS	DEG_SPOP_SBC_1	0.1111
p.K53Q	TCGA-BA-6872	HNSC	TCGA	PFSSS	DEG_SPOP_SBC_1	0.2222
p.K53Q	DO14236	HNSC	ICGC	PFSSS	DEG_SPOP_SBC_1	0.2222
p.K53Q	DO36556	READ	ICGC	PFSSS	DEG_SPOP_SBC_1	0.2222
p.A51V	TCGA-BR-4184	STAD	TCGA	PFSSS	DEG_SPOP_SBC_1	0.0556
p.A51V	DO38328	STAD	ICGC	PFSSS	DEG_SPOP_SBC_1	0.0556
p.P72S	DO227999	COCA	ICGC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	DO229010	COCA	ICGC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	DO229005	COCA	ICGC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	DO228941	LICA	ICGC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00437	Acute Myeloid Leukemia	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00338	Acute Myeloid Leukemia	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM01020	Plasma Cell Myeloma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00434	Plasma Cell Myeloma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00582	Pancreatic Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM01119	Other Solid Cancers	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00080	Melanoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00234	Other Solid Cancers	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00572	Gastric Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00614	Hepatocellular Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM01040	Ovarian Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00411	Pancreatic Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00584	Osteosarcoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00600	Thyroid Gland Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00281	Other Solid Cancers	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00607	Glioblastoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00568	Gastric Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00351	Oral Cavity Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00287	B-Lymphoblastic Leukemia	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00562	Breast Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00375	Head and Neck Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00459	B-Cell Non-Hodgkin's Lymphoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM01157	Other Solid Cancers	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00410	Other Blood Cancers	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00526	Chronic Myelogenous Leukemia	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00502	B-Lymphoblastic Leukemia	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00339	Non-Small Cell Lung Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM01653	Non-Cancerous	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00609	Kidney Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00574	Glioblastoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00245	Small Cell Lung Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00549	B-Lymphoblastic Leukemia	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00988	Kidney Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM01217	Other Blood Cancers	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00271	Gastric Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00324	Neuroblastoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00613	Glioblastoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00404	B-Cell Non-Hodgkin's Lymphoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00217	Colorectal Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00289	B-Lymphoblastic Leukemia	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00363	Acute Myeloid Leukemia	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00026	Other Solid Cancers	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM01609	Endometrial Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00165	Other Solid Cancers	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM01577	Plasma Cell Myeloma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM01470	Acute Myeloid Leukemia	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM01660	Kidney Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM01368	Gastric Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM01320	Pancreatic Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM01444	Glioblastoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM01336	Glioblastoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM01472	Hepatocellular Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM01779	Gastric Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM01691	Chronic Myelogenous Leukemia	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM01413	Oral Cavity Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM00171	Colorectal Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM01662	Plasma Cell Myeloma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.P72S	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.1389
p.A59S	DO229025	LICA	ICGC	PFSSS	DEG_SPOP_SBC_1	0.2778
p.R69M	DO229038	LICA	ICGC	PFSSS	DEG_SPOP_SBC_1	0.2222
p.N71T	DO218855	SKCA	ICGC	PFSSS	DEG_SPOP_SBC_1	0.1667
p.N71T	ACH-000793	Gastric Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	0.1667
p.N71T	ACH-000973	Bladder Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14526	F-BAR domain only protein 1	DEG_SPOP_SBC_1	463:467	PFSSS	SPOP	0.7117	More...
O14686	Histone-lysine N-methyltransferase 2D	DEG_SPOP_SBC_1	3172:3176	PFSSS	SPOP	0.987	More...
O15049	NEDD4-binding protein 3	DEG_SPOP_SBC_1	207:211	PFSSS	SPOP	0.9962	More...
O43294	Transforming growth factor beta-1-induced transcript 1 protein	DEG_SPOP_SBC_1	78:82	PFSSS	SPOP	0.9307	More...
O75385	Serine/threonine-protein kinase ULK1	DEG_SPOP_SBC_1	420:424	PFSSS	SPOP	0.9904	More...
O75916	Regulator of G-protein signaling 9	DEG_SPOP_SBC_1	495:499	PFSSS	SPOP	0.9118	More...
P16333	Cytoplasmic protein NCK1	DEG_SPOP_SBC_1	200:204	PFSSS	SPOP	0.8259	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	2761:2765	PFSSS	SPOP	0.996	More...
P33076	MHC class II transactivator	DEG_SPOP_SBC_1	211:215	PFSSS	SPOP	0.9232	More...
P98082	Disabled homolog 2	DEG_SPOP_SBC_1	365:369	PFSSS	SPOP	0.9901	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	826:830	PFSSS	SPOP	0.929	More...
Q3SXY7	Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3	DEG_SPOP_SBC_1	414:418	PFSSS	SPOP	0.7392	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	1367:1371	PFSSS	SPOP	0.6184	More...
Q68DE3	Basic helix-loop-helix domain-containing protein USF3	DEG_SPOP_SBC_1	1896:1900	PFSSS	SPOP	0.9564	More...
Q6RI45	Bromodomain and WD repeat-containing protein 3	DEG_SPOP_SBC_1	1518:1522	PFSSS	SPOP	0.8389	More...
Q8IZP9	Adhesion G-protein coupled receptor G2	DEG_SPOP_SBC_1	254:258	PFSSS	SPOP	0.786	More...
Q8N6G6	ADAMTS-like protein 1	DEG_SPOP_SBC_1	836:840	PFSSS	SPOP	0.7453	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10331:10335	PFSSS	SPOP	0.9441	More...
Q96J92	Serine/threonine-protein kinase WNK4	DEG_SPOP_SBC_1	864:868	PFSSS	SPOP	0.8261	More...
Q9BX66	Sorbin and SH3 domain-containing protein 1	DEG_SPOP_SBC_1	941:945	PFSSS	SPOP	0.9991	More...
Q9BYP7	Serine/threonine-protein kinase WNK3	DEG_SPOP_SBC_1	1144:1148	PFSSS	SPOP	0.938	More...
Q9HAK2	Transcription factor COE2	DEG_SPOP_SBC_1	527:531	PFSSS	SPOP	0.7804	More...
Q9NX40	OCIA domain-containing protein 1	DEG_SPOP_SBC_1	163:167	PFSSS	SPOP	0.9989	More...
Q9UBC2	Epidermal growth factor receptor substrate 15-like 1	DEG_SPOP_SBC_1	710:714	PFSSS	SPOP	0.9988	More...
Q9UQR0	Sex comb on midleg-like protein 2	DEG_SPOP_SBC_1	466:470	PFSSS	SPOP	0.9364	More...
Q86W28	NACHT, LRR and PYD domains-containing protein 8	DEG_SPOP_SBC_1	13:17	PFSSS	SPOP	0.9844	More...
Q8NDH2	Leucine-rich repeat transmembrane protein CCDC168	DEG_SPOP_SBC_1	350:354	PFSSS	SPOP	0.9972	More...
Q92545	Transmembrane protein 131	DEG_SPOP_SBC_1	1803:1807	PFSSS	SPOP	0.6327	More...
Q9ULL1	Pleckstrin homology domain-containing family G member 1	DEG_SPOP_SBC_1	61:65	PFSSS	SPOP	0.9867	More...
P0C879	Putative uncharacterized protein FLJ43185	DEG_SPOP_SBC_1	53:57	PFSSS	SPOP	0.9272	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PFSSS

Degron related mutations and impact score

Drug responses associated with PLEKHG1 mutations

All proteins holding degron of PFSSS