DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 10331:10335

E3 ligase: SPOP

DEGRON score: 0.9441

ASA_SCORE: 87.8

COIL: 0.8724

CONS_SCORE: 0

DSS_SCORE: 0.521

HELIX: 0.0174

FCONS_SCORE: 0

RIG_SCORE: 0.6593

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E10322D	TCGA-A5-A2K5	UCEC	TCGA	PFSSS	DEG_SPOP_SBC_1	0.0833
p.E10322D	DO41379	UCEC	ICGC	PFSSS	DEG_SPOP_SBC_1	0.0833
p.S10342Y	TCGA-AA-3977	COAD	TCGA	PFSSS	DEG_SPOP_SBC_1	0.5833
p.S10342Y	DO8730	COAD	ICGC	PFSSS	DEG_SPOP_SBC_1	0.5833
p.S10342F	TCGA-CN-4736	HNSC	TCGA	PFSSS	DEG_SPOP_SBC_1	0.5833
p.S10342F	DO15118	HNSC	ICGC	PFSSS	DEG_SPOP_SBC_1	0.5833
p.S10334F	TCGA-DD-A3A9	LIHC	TCGA	PFSSS	DEG_SPOP_SBC_1	0.7982
p.S10334F	TCGA-EE-A2MR	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	0.7982
p.S10334F	TCGA-Z2-AA3S	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	0.7982
p.S10334F	DO44888	LIHC	ICGC	PFSSS	DEG_SPOP_SBC_1	0.7982
p.S10334F	DO37819	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	0.7982
p.S10334F	DO51302	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	0.7982
p.S10333F	TCGA-EE-A2M5	SKCM	TCGA	PFSSS	DEG_SPOP_SBC_1	0.7982
p.S10333F	DO222423	MELA	ICGC	PFSSS	DEG_SPOP_SBC_1	0.7982
p.S10333F	DO222868	MELA	ICGC	PFSSS	DEG_SPOP_SBC_1	0.7982
p.S10333F	DO37425	SKCM	ICGC	PFSSS	DEG_SPOP_SBC_1	0.7982
p.P10329S	TCGA-PK-A5HC	ACC	TCGA	PFSSS	DEG_SPOP_SBC_1	0.2778
p.T10339N	DO229035	LICA	ICGC	PFSSS	DEG_SPOP_SBC_1	0.2222
p.T10338A	DO231040	LUSC	ICGC	PFSSS	DEG_SPOP_SBC_1	0.6944
p.F10332L	SIDM00513	Non-Small Cell Lung Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.587
p.F10332L	ACH-000161	Lung Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	0.587
p.F10332L	COR-L105	lung	COSMIC	PFSSS	DEG_SPOP_SBC_1	0.587
p.T10344S	SIDM00719	Small Cell Lung Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.0833
p.T10344S	ACH-001364	Lung Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	0.0833
p.T10344S	NCI-H345	lung	COSMIC	PFSSS	DEG_SPOP_SBC_1	0.0833
p.T10336N	SIDM00290	Gastric Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.3056
p.T10336N	ACH-000847	Gastric Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	0.3056
p.T10336N	HGC-27	stomach	COSMIC	PFSSS	DEG_SPOP_SBC_1	0.3056
p.P10329H	SIDM00217	Colorectal Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.2778
p.P10329H	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	0.2778
p.P10329H	ACH-000869	Lung Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	0.2778
p.P10329H	ACH-000999	Colon/Colorectal Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	0.2778
p.P10329H	SNU-1040	large_intestine	COSMIC	PFSSS	DEG_SPOP_SBC_1	0.2778
p.P10329H	NCI-H1568	lung	COSMIC	PFSSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14526	F-BAR domain only protein 1	DEG_SPOP_SBC_1	463:467	PFSSS	SPOP	0.7117	More...
O14686	Histone-lysine N-methyltransferase 2D	DEG_SPOP_SBC_1	3172:3176	PFSSS	SPOP	0.987	More...
O15049	NEDD4-binding protein 3	DEG_SPOP_SBC_1	207:211	PFSSS	SPOP	0.9962	More...
O43294	Transforming growth factor beta-1-induced transcript 1 protein	DEG_SPOP_SBC_1	78:82	PFSSS	SPOP	0.9307	More...
O75385	Serine/threonine-protein kinase ULK1	DEG_SPOP_SBC_1	420:424	PFSSS	SPOP	0.9904	More...
O75916	Regulator of G-protein signaling 9	DEG_SPOP_SBC_1	495:499	PFSSS	SPOP	0.9118	More...
P16333	Cytoplasmic protein NCK1	DEG_SPOP_SBC_1	200:204	PFSSS	SPOP	0.8259	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	2761:2765	PFSSS	SPOP	0.996	More...
P33076	MHC class II transactivator	DEG_SPOP_SBC_1	211:215	PFSSS	SPOP	0.9232	More...
P98082	Disabled homolog 2	DEG_SPOP_SBC_1	365:369	PFSSS	SPOP	0.9901	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	826:830	PFSSS	SPOP	0.929	More...
Q3SXY7	Leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 3	DEG_SPOP_SBC_1	414:418	PFSSS	SPOP	0.7392	More...
Q5T011	KICSTOR complex protein SZT2	DEG_SPOP_SBC_1	1367:1371	PFSSS	SPOP	0.6184	More...
Q68DE3	Basic helix-loop-helix domain-containing protein USF3	DEG_SPOP_SBC_1	1896:1900	PFSSS	SPOP	0.9564	More...
Q6RI45	Bromodomain and WD repeat-containing protein 3	DEG_SPOP_SBC_1	1518:1522	PFSSS	SPOP	0.8389	More...
Q8IZP9	Adhesion G-protein coupled receptor G2	DEG_SPOP_SBC_1	254:258	PFSSS	SPOP	0.786	More...
Q8N6G6	ADAMTS-like protein 1	DEG_SPOP_SBC_1	836:840	PFSSS	SPOP	0.7453	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	10331:10335	PFSSS	SPOP	0.9441	More...
Q96J92	Serine/threonine-protein kinase WNK4	DEG_SPOP_SBC_1	864:868	PFSSS	SPOP	0.8261	More...
Q9BX66	Sorbin and SH3 domain-containing protein 1	DEG_SPOP_SBC_1	941:945	PFSSS	SPOP	0.9991	More...
Q9BYP7	Serine/threonine-protein kinase WNK3	DEG_SPOP_SBC_1	1144:1148	PFSSS	SPOP	0.938	More...
Q9HAK2	Transcription factor COE2	DEG_SPOP_SBC_1	527:531	PFSSS	SPOP	0.7804	More...
Q9NX40	OCIA domain-containing protein 1	DEG_SPOP_SBC_1	163:167	PFSSS	SPOP	0.9989	More...
Q9UBC2	Epidermal growth factor receptor substrate 15-like 1	DEG_SPOP_SBC_1	710:714	PFSSS	SPOP	0.9988	More...
Q9UQR0	Sex comb on midleg-like protein 2	DEG_SPOP_SBC_1	466:470	PFSSS	SPOP	0.9364	More...
Q86W28	NACHT, LRR and PYD domains-containing protein 8	DEG_SPOP_SBC_1	13:17	PFSSS	SPOP	0.9844	More...
Q8NDH2	Leucine-rich repeat transmembrane protein CCDC168	DEG_SPOP_SBC_1	350:354	PFSSS	SPOP	0.9972	More...
Q92545	Transmembrane protein 131	DEG_SPOP_SBC_1	1803:1807	PFSSS	SPOP	0.6327	More...
Q9ULL1	Pleckstrin homology domain-containing family G member 1	DEG_SPOP_SBC_1	61:65	PFSSS	SPOP	0.9867	More...
P0C879	Putative uncharacterized protein FLJ43185	DEG_SPOP_SBC_1	53:57	PFSSS	SPOP	0.9272	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PFSSS

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of PFSSS