DegronMD - Q8N6G6(ADAMTSL1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K494E	TCGA-49-6743	LUAD	TCGA	EECIVPTP	DEG_COP1_1	484:491	Mutation substituting flanking lysine	0.3611
p.K494E	DO26092	LUAD	ICGC	EECIVPTP	DEG_COP1_1	484:491	Mutation substituting flanking lysine	0.3611
p.P833L	TCGA-AJ-A3OL	UCEC	TCGA	PFSSS	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.25
p.P833L	DO43001	UCEC	ICGC	PFSSS	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.25
p.L831M	TCGA-AP-A0LM	UCEC	TCGA	PFSSS	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.1944
p.L831M	DO43306	UCEC	ICGC	PFSSS	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.1944
p.V501I	TCGA-B5-A1MX	UCEC	TCGA	EECIVPTP	DEG_COP1_1	484:491	Mutation rewiring degron network	0.0556
p.V501I	DO41999	UCEC	ICGC	EECIVPTP	DEG_COP1_1	484:491	Mutation rewiring degron network	0.0556
p.P500Q	TCGA-CV-7102	HNSC	TCGA	EECIVPTP	DEG_COP1_1	484:491	Mutation rewiring degron network	0.0833
p.P500Q	DO14194	HNSC	ICGC	EECIVPTP	DEG_COP1_1	484:491	Mutation rewiring degron network	0.0833
p.R842W	TCGA-XE-A8H5	TGCT	TCGA	PFSSS	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.2778
p.I841F	DO225072	BRCA	ICGC	PFSSS	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.3056
p.I841F	DO227701	BRCA	ICGC	PFSSS	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.3056
p.P489S	DO234230	ESAD	ICGC	EECIVPTP	DEG_COP1_1	484:491	Mutation altering degron motif	0.6752
p.R842T	DO48197	ESCA	ICGC	PFSSS	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.2778
p.S840C	DO25797	LUAD	ICGC	PFSSS	DEG_SPOP_SBC_1	836:840	Mutation altering degron motif	0.7541
p.S840C	SIDM00128	Head and Neck Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	836:840	Mutation altering degron motif	0.7541
p.S840C	ACH-002249	Head and Neck Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	836:840	Mutation altering degron motif	0.7541
p.S840C	JHU-011	upper aerodigestive tract	COSMIC	PFSSS	DEG_SPOP_SBC_1	836:840	Mutation altering degron motif	0.7541
p.E485K	DO222662	MELA	ICGC	EECIVPTP	DEG_COP1_1	484:491	Mutation altering degron motif	0.7022
p.V488I	DO51180	PAEN	ICGC	EECIVPTP	DEG_COP1_1	484:491	Mutation altering degron motif	0.7076
p.V488I	SIDM01039	Other Solid Cancers	GDSC	EECIVPTP	DEG_COP1_1	484:491	Mutation altering degron motif	0.7076
p.V488I	JAR	placenta	COSMIC	EECIVPTP	DEG_COP1_1	484:491	Mutation altering degron motif	0.7076
p.T830A	DO232761	PBCA	ICGC	PFSSS	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.1667
p.S839F	SIDM01203	Other Solid Cancers	GDSC	PFSSS	DEG_SPOP_SBC_1	836:840	Mutation altering degron motif	0.7982
p.S839F	ACH-002291	Embryonal Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	836:840	Mutation altering degron motif	0.7982
p.S839F	NTERA-2_cl_D1	testis	COSMIC	PFSSS	DEG_SPOP_SBC_1	836:840	Mutation altering degron motif	0.7982
p.A847E	SIDM01129	Small Cell Lung Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.1389
p.A847E	ACH-000816	Lung Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.1389
p.A847E	NCI-H524	lung	COSMIC	PFSSS	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.1389
p.K479R	SIDM01045	Endometrial Carcinoma	GDSC	EECIVPTP	DEG_COP1_1	484:491	Mutation substituting flanking lysine	0.3056
p.K479R	ACH-000978	Endometrial/Uterine Cancer	CCLE	EECIVPTP	DEG_COP1_1	484:491	Mutation substituting flanking lysine	0.3056
p.K479R	EN	endometrium	COSMIC	EECIVPTP	DEG_COP1_1	484:491	Mutation substituting flanking lysine	0.3056
p.N828Y	SIDM01019	Acute Myeloid Leukemia	GDSC	PFSSS	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.1111
p.N828Y	ACH-002258	Leukemia	CCLE	PFSSS	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.1111
p.N828Y	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	PFSSS	DEG_SPOP_SBC_1	836:840	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADAMTSL1

UniProt ID: Q8N6G6

Entrez ID: 92949

Protein name: ADAMTS-like protein 1 (ADAMTSL-1) (Punctin-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ADAMTSL1 in