DegronMD

Uniprot ID: Q8N6G6

Source protein: ADAMTS-like protein 1

Source gene: ADAMTSL1

Class: DEG_COP1_1

Location: 484:491

E3 ligase: COP1

DEGRON score: 0.7305

ASA_SCORE: 80.425

COIL: 0.7933

CONS_SCORE: 0.5713

DSS_SCORE: 0.2668

HELIX: 0.0168

FCONS_SCORE: 1.0916

RIG_SCORE: 0.8015

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K494E	TCGA-49-6743	LUAD	TCGA	EECIVPTP	DEG_COP1_1	0.3611
p.K494E	DO26092	LUAD	ICGC	EECIVPTP	DEG_COP1_1	0.3611
p.V501I	TCGA-B5-A1MX	UCEC	TCGA	EECIVPTP	DEG_COP1_1	0.0556
p.V501I	DO41999	UCEC	ICGC	EECIVPTP	DEG_COP1_1	0.0556
p.P500Q	TCGA-CV-7102	HNSC	TCGA	EECIVPTP	DEG_COP1_1	0.0833
p.P500Q	DO14194	HNSC	ICGC	EECIVPTP	DEG_COP1_1	0.0833
p.P489S	DO234230	ESAD	ICGC	EECIVPTP	DEG_COP1_1	0.6752
p.E485K	DO222662	MELA	ICGC	EECIVPTP	DEG_COP1_1	0.7022
p.V488I	DO51180	PAEN	ICGC	EECIVPTP	DEG_COP1_1	0.7076
p.V488I	SIDM01039	Other Solid Cancers	GDSC	EECIVPTP	DEG_COP1_1	0.7076
p.V488I	JAR	placenta	COSMIC	EECIVPTP	DEG_COP1_1	0.7076
p.K479R	SIDM01045	Endometrial Carcinoma	GDSC	EECIVPTP	DEG_COP1_1	0.3056
p.K479R	ACH-000978	Endometrial/Uterine Cancer	CCLE	EECIVPTP	DEG_COP1_1	0.3056
p.K479R	EN	endometrium	COSMIC	EECIVPTP	DEG_COP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N6G6	ADAMTS-like protein 1	DEG_COP1_1	484:491	EECIVPTP	COP1	0.7305	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons