DegronMD - Q9ULL1(PLEKHG1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G639E	TCGA-02-0047	GBM	TCGA	MTPFGS	DEG_SCF_FBW7_1	643:648	Mutation rewiring degron network	0.2222
p.G639E	DO11669	GBM	ICGC	MTPFGS	DEG_SCF_FBW7_1	643:648	Mutation rewiring degron network	0.2222
p.L1344M	TCGA-04-1649	OV	TCGA	LTPYND	LIG_APCC_ABBA_1	1344:1349	Mutation altering degron motif	0.5999
p.L1344M	DO32467	OV	ICGC	LTPYND	LIG_APCC_ABBA_1	1344:1349	Mutation altering degron motif	0.5999
p.S684P	TCGA-06-1802	GBM	TCGA	EAESTPSK	DEG_SCF_SKP2-CKS1_1	678:685	Mutation altering degron motif	0.5641
p.S684P	DO12100	GBM	ICGC	EAESTPSK	DEG_SCF_SKP2-CKS1_1	678:685	Mutation altering degron motif	0.5641
p.L900R	TCGA-21-1080	LUSC	TCGA	LLTPVKS	DEG_SCF_FBW7_1	899:905	Mutation altering degron motif	0.7316
p.L900R	DO26502	LUSC	ICGC	LLTPVKS	DEG_SCF_FBW7_1	899:905	Mutation altering degron motif	0.7316
p.L1357H	TCGA-22-1005	LUSC	TCGA	LTPYND	LIG_APCC_ABBA_1	1344:1349	Mutation rewiring degron network	0.1111
p.L1357H	DO26632	LUSC	ICGC	LTPYND	LIG_APCC_ABBA_1	1344:1349	Mutation rewiring degron network	0.1111
p.G647R	TCGA-30-1718	OV	TCGA	MTPFGS	DEG_SCF_FBW7_1	643:648	Mutation altering degron motif	0.6457
p.G647R	DO32708	OV	ICGC	MTPFGS	DEG_SCF_FBW7_1	643:648	Mutation altering degron motif	0.6457
p.G647R	SIDM00831	Head and Neck Carcinoma	GDSC	MTPFGS	DEG_SCF_FBW7_1	643:648	Mutation altering degron motif	0.6457
p.G647R	ACH-000207	Head and Neck Cancer	CCLE	MTPFGS	DEG_SCF_FBW7_1	643:648	Mutation altering degron motif	0.6457
p.G647R	Detroit562	upper aerodigestive tract	COSMIC	MTPFGS	DEG_SCF_FBW7_1	643:648	Mutation altering degron motif	0.6457
p.V1334D	TCGA-56-A62T	LUSC	TCGA	LTPYND	LIG_APCC_ABBA_1	1344:1349	Mutation rewiring degron network	0.0556
p.V1334D	TCGA-UF-A7JT	HNSC	TCGA	LTPYND	LIG_APCC_ABBA_1	1344:1349	Mutation rewiring degron network	0.0556
p.V1334D	DO219090	HNSC	ICGC	LTPYND	LIG_APCC_ABBA_1	1344:1349	Mutation rewiring degron network	0.0556
p.V1334D	DO219144	LUSC	ICGC	LTPYND	LIG_APCC_ABBA_1	1344:1349	Mutation rewiring degron network	0.0556
p.A73T	TCGA-AA-3715	COAD	TCGA	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1111
p.A73T	DO8018	COAD	ICGC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1111
p.R524Q	TCGA-AX-A1CE	UCEC	TCGA	PSSST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.1667
p.R524Q	DO42280	UCEC	ICGC	PSSST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.1667
p.R692H	TCGA-AX-A1CE	UCEC	TCGA	EAESTPSK	DEG_SCF_SKP2-CKS1_1	678:685	Mutation rewiring degron network	0.1389
p.R692H	DO234230	ESAD	ICGC	EAESTPSK	DEG_SCF_SKP2-CKS1_1	678:685	Mutation rewiring degron network	0.1389
p.R692H	DO42280	UCEC	ICGC	EAESTPSK	DEG_SCF_SKP2-CKS1_1	678:685	Mutation rewiring degron network	0.1389
p.S506F	TCGA-B5-A0JN	UCEC	TCGA	PSSST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.1111
p.S506F	DO41943	UCEC	ICGC	PSSST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.1111
p.K53Q	TCGA-BA-6872	HNSC	TCGA	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation substituting flanking lysine	0.2222
p.K53Q	DO14236	HNSC	ICGC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation substituting flanking lysine	0.2222
p.K53Q	DO36556	READ	ICGC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation substituting flanking lysine	0.2222
p.A51V	TCGA-BR-4184	STAD	TCGA	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.0556
p.A51V	DO38328	STAD	ICGC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.0556
p.R676W	TCGA-BR-4370	STAD	TCGA	EAESTPSK	DEG_SCF_SKP2-CKS1_1	678:685	Mutation rewiring degron network	0.2778
p.R676W	DO233261	GACA	ICGC	EAESTPSK	DEG_SCF_SKP2-CKS1_1	678:685	Mutation rewiring degron network	0.2778
p.R676W	DO38499	STAD	ICGC	EAESTPSK	DEG_SCF_SKP2-CKS1_1	678:685	Mutation rewiring degron network	0.2778
p.R676W	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	EAESTPSK	DEG_SCF_SKP2-CKS1_1	678:685	Mutation rewiring degron network	0.2778
p.R676W	KYSE-50	oesophagus	COSMIC	EAESTPSK	DEG_SCF_SKP2-CKS1_1	678:685	Mutation rewiring degron network	0.2778
p.R676Q	TCGA-BS-A0UV	UCEC	TCGA	EAESTPSK	DEG_SCF_SKP2-CKS1_1	678:685	Mutation rewiring degron network	0.2778
p.R676Q	DO42793	UCEC	ICGC	EAESTPSK	DEG_SCF_SKP2-CKS1_1	678:685	Mutation rewiring degron network	0.2778
p.G647A	TCGA-CN-6019	HNSC	TCGA	MTPFGS	DEG_SCF_FBW7_1	643:648	Mutation altering degron motif	0.6429
p.G647A	DO14316	HNSC	ICGC	MTPFGS	DEG_SCF_FBW7_1	643:648	Mutation altering degron motif	0.6429
p.P505L	TCGA-CN-A63W	HNSC	TCGA	PSSST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.0833
p.P505L	DO49031	HNSC	ICGC	PSSST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.0833
p.E651Q	TCGA-CR-6472	HNSC	TCGA	MTPFGS	DEG_SCF_FBW7_1	643:648	Mutation rewiring degron network	0.25
p.E651Q	DO15870	HNSC	ICGC	MTPFGS	DEG_SCF_FBW7_1	643:648	Mutation rewiring degron network	0.25
p.R676L	TCGA-CV-7102	HNSC	TCGA	EAESTPSK	DEG_SCF_SKP2-CKS1_1	678:685	Mutation rewiring degron network	0.2778
p.R676L	DO14194	HNSC	ICGC	EAESTPSK	DEG_SCF_SKP2-CKS1_1	678:685	Mutation rewiring degron network	0.2778
p.L1357R	TCGA-DD-A1EE	LIHC	TCGA	LTPYND	LIG_APCC_ABBA_1	1344:1349	Mutation rewiring degron network	0.1111
p.L1357R	TCGA-EP-A26S	LIHC	TCGA	LTPYND	LIG_APCC_ABBA_1	1344:1349	Mutation rewiring degron network	0.1111
p.L1357R	DO22857	LIHC	ICGC	LTPYND	LIG_APCC_ABBA_1	1344:1349	Mutation rewiring degron network	0.1111
p.L1357R	DO22854	LIHC	ICGC	LTPYND	LIG_APCC_ABBA_1	1344:1349	Mutation rewiring degron network	0.1111
p.A525V	TCGA-DZ-6133	KIRP	TCGA	PSSST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.1389
p.A525V	DO20762	KIRP	ICGC	PSSST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.1389
p.P645L	TCGA-EE-A2MD	SKCM	TCGA	MTPFGS	DEG_SCF_FBW7_1	643:648	Mutation altering degron motif	0.7582
p.P645L	TCGA-EE-A3AC	SKCM	TCGA	MTPFGS	DEG_SCF_FBW7_1	643:648	Mutation altering degron motif	0.7582
p.P645L	DO222434	MELA	ICGC	MTPFGS	DEG_SCF_FBW7_1	643:648	Mutation altering degron motif	0.7582
p.P645L	DO37631	SKCM	ICGC	MTPFGS	DEG_SCF_FBW7_1	643:648	Mutation altering degron motif	0.7582
p.P645L	DO37851	SKCM	ICGC	MTPFGS	DEG_SCF_FBW7_1	643:648	Mutation altering degron motif	0.7582
p.F646L	TCGA-ER-A19D	SKCM	TCGA	MTPFGS	DEG_SCF_FBW7_1	643:648	Mutation altering degron motif	0.587
p.F646L	DO37750	SKCM	ICGC	MTPFGS	DEG_SCF_FBW7_1	643:648	Mutation altering degron motif	0.587
p.N1348T	TCGA-F5-6814	READ	TCGA	LTPYND	LIG_APCC_ABBA_1	1344:1349	Mutation altering degron motif	0.5944
p.N1348T	DO36556	READ	ICGC	LTPYND	LIG_APCC_ABBA_1	1344:1349	Mutation altering degron motif	0.5944
p.A913T	TCGA-G4-6586	COAD	TCGA	LLTPVKS	DEG_SCF_FBW7_1	899:905	Mutation rewiring degron network	0.1111
p.A913T	DO9698	COAD	ICGC	LLTPVKS	DEG_SCF_FBW7_1	899:905	Mutation rewiring degron network	0.1111
p.A913T	DO233888	GACA	ICGC	LLTPVKS	DEG_SCF_FBW7_1	899:905	Mutation rewiring degron network	0.1111
p.A898V	TCGA-GN-A266	SKCM	TCGA	LLTPVKS	DEG_SCF_FBW7_1	899:905	Mutation rewiring degron network	0.3056
p.A898V	DO37432	SKCM	ICGC	LLTPVKS	DEG_SCF_FBW7_1	899:905	Mutation rewiring degron network	0.3056
p.G639R	TCGA-HC-7750	PRAD	TCGA	MTPFGS	DEG_SCF_FBW7_1	643:648	Mutation rewiring degron network	0.2222
p.G639R	DO36317	PRAD	ICGC	MTPFGS	DEG_SCF_FBW7_1	643:648	Mutation rewiring degron network	0.2222
p.R692C	TCGA-W3-AA1O	SKCM	TCGA	EAESTPSK	DEG_SCF_SKP2-CKS1_1	678:685	Mutation rewiring degron network	0.1389
p.R692C	DO233884	GACA	ICGC	EAESTPSK	DEG_SCF_SKP2-CKS1_1	678:685	Mutation rewiring degron network	0.1389
p.R692C	DO51274	SKCM	ICGC	EAESTPSK	DEG_SCF_SKP2-CKS1_1	678:685	Mutation rewiring degron network	0.1389
p.E895Q	DO225354	BRCA	ICGC	LLTPVKS	DEG_SCF_FBW7_1	899:905	Mutation rewiring degron network	0.2222
p.P72S	DO227999	COCA	ICGC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	DO229010	COCA	ICGC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	DO229005	COCA	ICGC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	DO228941	LICA	ICGC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00437	Acute Myeloid Leukemia	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00338	Acute Myeloid Leukemia	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM01020	Plasma Cell Myeloma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00434	Plasma Cell Myeloma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00582	Pancreatic Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM01119	Other Solid Cancers	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00080	Melanoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00234	Other Solid Cancers	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00572	Gastric Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00614	Hepatocellular Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM01040	Ovarian Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00411	Pancreatic Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00584	Osteosarcoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00600	Thyroid Gland Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00551	Esophageal Squamous Cell Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00281	Other Solid Cancers	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00607	Glioblastoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00354	Squamous Cell Lung Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00568	Gastric Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00351	Oral Cavity Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00287	B-Lymphoblastic Leukemia	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00562	Breast Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00375	Head and Neck Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00459	B-Cell Non-Hodgkin's Lymphoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM01157	Other Solid Cancers	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00410	Other Blood Cancers	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00526	Chronic Myelogenous Leukemia	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00502	B-Lymphoblastic Leukemia	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00339	Non-Small Cell Lung Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM01653	Non-Cancerous	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00609	Kidney Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00325	Esophageal Squamous Cell Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00574	Glioblastoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00245	Small Cell Lung Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00283	B-Cell Non-Hodgkin's Lymphoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00549	B-Lymphoblastic Leukemia	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00988	Kidney Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM01217	Other Blood Cancers	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00271	Gastric Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00324	Neuroblastoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00613	Glioblastoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00404	B-Cell Non-Hodgkin's Lymphoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00217	Colorectal Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00326	Esophageal Squamous Cell Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00289	B-Lymphoblastic Leukemia	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00363	Acute Myeloid Leukemia	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00448	B-Cell Non-Hodgkin's Lymphoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00026	Other Solid Cancers	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM01609	Endometrial Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00165	Other Solid Cancers	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM01577	Plasma Cell Myeloma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM01470	Acute Myeloid Leukemia	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM01660	Kidney Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM01368	Gastric Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM01320	Pancreatic Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM01444	Glioblastoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM01336	Glioblastoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM01472	Hepatocellular Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM01779	Gastric Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM01691	Chronic Myelogenous Leukemia	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM01413	Oral Cavity Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM00171	Colorectal Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM01662	Plasma Cell Myeloma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.P72S	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1389
p.V903A	DO222769	COCA	ICGC	LLTPVKS	DEG_SCF_FBW7_1	899:905	Mutation altering degron motif	0.5825
p.T901M	DO234336	ESAD	ICGC	LLTPVKS	DEG_SCF_FBW7_1	899:905	Mutation altering degron motif	0.8534
p.A59S	DO229025	LICA	ICGC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.2778
p.Q509H	DO229026	LICA	ICGC	PSSST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.1944
p.G1339C	DO229036	LICA	ICGC	LTPYND	LIG_APCC_ABBA_1	1344:1349	Mutation rewiring degron network	0.1944
p.R504M	DO229035	LICA	ICGC	PSSST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.0556
p.R69M	DO229038	LICA	ICGC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.2222
p.S516I	DO229045	LICA	ICGC	PSSST	DEG_SPOP_SBC_1	514:518	Mutation altering degron motif	0.7341
p.L893M	DO232224	PBCA	ICGC	LLTPVKS	DEG_SCF_FBW7_1	899:905	Mutation rewiring degron network	0.1667
p.A910T	DO228012	SKCA	ICGC	LLTPVKS	DEG_SCF_FBW7_1	899:905	Mutation rewiring degron network	0.1944
p.N71T	DO218855	SKCA	ICGC	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1667
p.N71T	ACH-000793	Gastric Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1667
p.N71T	ACH-000973	Bladder Cancer	CCLE	PFSSS	DEG_SPOP_SBC_1	61:65	Mutation rewiring degron network	0.1667
p.P514S	SIDM01266	Colorectal Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	514:518	Mutation altering degron motif	0.6752
p.S690F	SIDM01175	Other Sarcomas	GDSC	EAESTPSK	DEG_SCF_SKP2-CKS1_1	678:685	Mutation blocking phosphorylation signal	0.6389
p.S690F	ACH-002309	Sarcoma	CCLE	EAESTPSK	DEG_SCF_SKP2-CKS1_1	678:685	Mutation blocking phosphorylation signal	0.6389
p.S690F	SW684	soft tissue	COSMIC	EAESTPSK	DEG_SCF_SKP2-CKS1_1	678:685	Mutation blocking phosphorylation signal	0.6389
p.A508V	SIDM00899	Pancreatic Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.1667
p.A508V	ACH-000222	Pancreatic Cancer	CCLE	PSSST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.1667
p.A508V	AsPC-1	pancreas	COSMIC	PSSST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.1667
p.S681T	SIDM00878	Breast Carcinoma	GDSC	EAESTPSK	DEG_SCF_SKP2-CKS1_1	678:685	Mutation altering degron motif	0.7116
p.S681T	ACH-000930	Breast Cancer	CCLE	EAESTPSK	DEG_SCF_SKP2-CKS1_1	678:685	Mutation altering degron motif	0.7116
p.S681T	HCC1569	breast	COSMIC	EAESTPSK	DEG_SCF_SKP2-CKS1_1	678:685	Mutation altering degron motif	0.7116
p.V522M	SIDM00121	T-Lymphoblastic Leukemia	GDSC	PSSST	DEG_SPOP_SBC_1	514:518	Mutation rewiring degron network	0.2222
p.E642D	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	MTPFGS	DEG_SCF_FBW7_1	643:648	Mutation rewiring degron network	0.3056
p.E642D	SIDM00479	Esophageal Carcinoma	GDSC	MTPFGS	DEG_SCF_FBW7_1	643:648	Mutation rewiring degron network	0.3056
p.L891M	ACH-002089	Lung Cancer	CCLE	LLTPVKS	DEG_SCF_FBW7_1	899:905	Mutation rewiring degron network	0.1111
p.L891M	201T	lung	COSMIC	LLTPVKS	DEG_SCF_FBW7_1	899:905	Mutation rewiring degron network	0.1111
p.C915Y	PF-382	haematopoietic and lymphoid tissue	COSMIC	LLTPVKS	DEG_SCF_FBW7_1	899:905	Mutation rewiring degron network	0.0556

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLEKHG1

UniProt ID: Q9ULL1

Entrez ID: 57480

Protein name: Pleckstrin homology domain-containing family G member 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLEKHG1 in