DegronMD

Uniprot ID: Q9ULL1

Source protein: Pleckstrin homology domain-containing family G member 1

Source gene: PLEKHG1

Class: DEG_SCF_SKP2-CKS1_1

Location: 678:685

E3 ligase: SKP2,CSK1

DEGRON score: 0.8568

ASA_SCORE: 97.6875

COIL: 0.7658

CONS_SCORE: 0.2903

DSS_SCORE: 0.5806

HELIX: 0.2084

FCONS_SCORE: 0.907

RIG_SCORE: 0.635

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S684P	TCGA-06-1802	GBM	TCGA	EAESTPSK	DEG_SCF_SKP2-CKS1_1	0.5641
p.S684P	DO12100	GBM	ICGC	EAESTPSK	DEG_SCF_SKP2-CKS1_1	0.5641
p.R692H	TCGA-AX-A1CE	UCEC	TCGA	EAESTPSK	DEG_SCF_SKP2-CKS1_1	0.1389
p.R692H	DO234230	ESAD	ICGC	EAESTPSK	DEG_SCF_SKP2-CKS1_1	0.1389
p.R692H	DO42280	UCEC	ICGC	EAESTPSK	DEG_SCF_SKP2-CKS1_1	0.1389
p.R676W	TCGA-BR-4370	STAD	TCGA	EAESTPSK	DEG_SCF_SKP2-CKS1_1	0.2778
p.R676W	DO233261	GACA	ICGC	EAESTPSK	DEG_SCF_SKP2-CKS1_1	0.2778
p.R676W	DO38499	STAD	ICGC	EAESTPSK	DEG_SCF_SKP2-CKS1_1	0.2778
p.R676W	SIDM00550	Esophageal Squamous Cell Carcinoma	GDSC	EAESTPSK	DEG_SCF_SKP2-CKS1_1	0.2778
p.R676W	KYSE-50	oesophagus	COSMIC	EAESTPSK	DEG_SCF_SKP2-CKS1_1	0.2778
p.R676Q	TCGA-BS-A0UV	UCEC	TCGA	EAESTPSK	DEG_SCF_SKP2-CKS1_1	0.2778
p.R676Q	DO42793	UCEC	ICGC	EAESTPSK	DEG_SCF_SKP2-CKS1_1	0.2778
p.R676L	TCGA-CV-7102	HNSC	TCGA	EAESTPSK	DEG_SCF_SKP2-CKS1_1	0.2778
p.R676L	DO14194	HNSC	ICGC	EAESTPSK	DEG_SCF_SKP2-CKS1_1	0.2778
p.R692C	TCGA-W3-AA1O	SKCM	TCGA	EAESTPSK	DEG_SCF_SKP2-CKS1_1	0.1389
p.R692C	DO233884	GACA	ICGC	EAESTPSK	DEG_SCF_SKP2-CKS1_1	0.1389
p.R692C	DO51274	SKCM	ICGC	EAESTPSK	DEG_SCF_SKP2-CKS1_1	0.1389
p.S690F	SIDM01175	Other Sarcomas	GDSC	EAESTPSK	DEG_SCF_SKP2-CKS1_1	0.6389
p.S690F	ACH-002309	Sarcoma	CCLE	EAESTPSK	DEG_SCF_SKP2-CKS1_1	0.6389
p.S690F	SW684	soft_tissue	COSMIC	EAESTPSK	DEG_SCF_SKP2-CKS1_1	0.6389
p.S681T	SIDM00878	Breast Carcinoma	GDSC	EAESTPSK	DEG_SCF_SKP2-CKS1_1	0.7116
p.S681T	ACH-000930	Breast Cancer	CCLE	EAESTPSK	DEG_SCF_SKP2-CKS1_1	0.7116
p.S681T	HCC1569	breast	COSMIC	EAESTPSK	DEG_SCF_SKP2-CKS1_1	0.7116

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULL1	Pleckstrin homology domain-containing family G member 1	DEG_SCF_SKP2-CKS1_1	678:685	EAESTPSK	SKP2,CSK1	0.8568	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons