DegronMD

Uniprot ID: Q9ULL1

Source protein: Pleckstrin homology domain-containing family G member 1

Source gene: PLEKHG1

Class: DEG_SCF_FBW7_1

Location: 643:648

E3 ligase: FBXW7

DEGRON score: 0.999

ASA_SCORE: 76.05

COIL: 0.8533

CONS_SCORE: 0.3968

DSS_SCORE: 0.5929

HELIX: 0.0728

FCONS_SCORE: 1.1786

RIG_SCORE: 0.7001

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G639E	TCGA-02-0047	GBM	TCGA	MTPFGS	DEG_SCF_FBW7_1	0.2222
p.G639E	DO11669	GBM	ICGC	MTPFGS	DEG_SCF_FBW7_1	0.2222
p.G647R	TCGA-30-1718	OV	TCGA	MTPFGS	DEG_SCF_FBW7_1	0.6457
p.G647R	DO32708	OV	ICGC	MTPFGS	DEG_SCF_FBW7_1	0.6457
p.G647R	SIDM00831	Head and Neck Carcinoma	GDSC	MTPFGS	DEG_SCF_FBW7_1	0.6457
p.G647R	ACH-000207	Head and Neck Cancer	CCLE	MTPFGS	DEG_SCF_FBW7_1	0.6457
p.G647R	Detroit562	upper_aerodigestive_tract	COSMIC	MTPFGS	DEG_SCF_FBW7_1	0.6457
p.G647A	TCGA-CN-6019	HNSC	TCGA	MTPFGS	DEG_SCF_FBW7_1	0.6429
p.G647A	DO14316	HNSC	ICGC	MTPFGS	DEG_SCF_FBW7_1	0.6429
p.E651Q	TCGA-CR-6472	HNSC	TCGA	MTPFGS	DEG_SCF_FBW7_1	0.25
p.E651Q	DO15870	HNSC	ICGC	MTPFGS	DEG_SCF_FBW7_1	0.25
p.P645L	TCGA-EE-A2MD	SKCM	TCGA	MTPFGS	DEG_SCF_FBW7_1	0.7582
p.P645L	TCGA-EE-A3AC	SKCM	TCGA	MTPFGS	DEG_SCF_FBW7_1	0.7582
p.P645L	DO222434	MELA	ICGC	MTPFGS	DEG_SCF_FBW7_1	0.7582
p.P645L	DO37631	SKCM	ICGC	MTPFGS	DEG_SCF_FBW7_1	0.7582
p.P645L	DO37851	SKCM	ICGC	MTPFGS	DEG_SCF_FBW7_1	0.7582
p.F646L	TCGA-ER-A19D	SKCM	TCGA	MTPFGS	DEG_SCF_FBW7_1	0.587
p.F646L	DO37750	SKCM	ICGC	MTPFGS	DEG_SCF_FBW7_1	0.587
p.G639R	TCGA-HC-7750	PRAD	TCGA	MTPFGS	DEG_SCF_FBW7_1	0.2222
p.G639R	DO36317	PRAD	ICGC	MTPFGS	DEG_SCF_FBW7_1	0.2222
p.E642D	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	MTPFGS	DEG_SCF_FBW7_1	0.3056
p.E642D	SIDM00479	Esophageal Carcinoma	GDSC	MTPFGS	DEG_SCF_FBW7_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULL1	Pleckstrin homology domain-containing family G member 1	DEG_SCF_FBW7_1	643:648	MTPFGS	FBXW7	0.999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons