DegronMD

Uniprot ID: Q9ULL1

Source protein: Pleckstrin homology domain-containing family G member 1

Source gene: PLEKHG1

Class: DEG_SCF_FBW7_1

Location: 899:905

E3 ligase: FBXW7

DEGRON score: 0.9535

ASA_SCORE: 77.7286

COIL: 0.7076

CONS_SCORE: 0.2824

DSS_SCORE: 0.4767

HELIX: 0.2317

FCONS_SCORE: 0.9377

RIG_SCORE: 0.7523

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L900R	TCGA-21-1080	LUSC	TCGA	LLTPVKS	DEG_SCF_FBW7_1	0.7316
p.L900R	DO26502	LUSC	ICGC	LLTPVKS	DEG_SCF_FBW7_1	0.7316
p.A913T	TCGA-G4-6586	COAD	TCGA	LLTPVKS	DEG_SCF_FBW7_1	0.1111
p.A913T	DO9698	COAD	ICGC	LLTPVKS	DEG_SCF_FBW7_1	0.1111
p.A913T	DO233888	GACA	ICGC	LLTPVKS	DEG_SCF_FBW7_1	0.1111
p.A898V	TCGA-GN-A266	SKCM	TCGA	LLTPVKS	DEG_SCF_FBW7_1	0.3056
p.A898V	DO37432	SKCM	ICGC	LLTPVKS	DEG_SCF_FBW7_1	0.3056
p.E895Q	DO225354	BRCA	ICGC	LLTPVKS	DEG_SCF_FBW7_1	0.2222
p.V903A	DO222769	COCA	ICGC	LLTPVKS	DEG_SCF_FBW7_1	0.5825
p.T901M	DO234336	ESAD	ICGC	LLTPVKS	DEG_SCF_FBW7_1	0.8534
p.L893M	DO232224	PBCA	ICGC	LLTPVKS	DEG_SCF_FBW7_1	0.1667
p.A910T	DO228012	SKCA	ICGC	LLTPVKS	DEG_SCF_FBW7_1	0.1944
p.L891M	ACH-002089	Lung Cancer	CCLE	LLTPVKS	DEG_SCF_FBW7_1	0.1111
p.L891M	201T	lung	COSMIC	LLTPVKS	DEG_SCF_FBW7_1	0.1111
p.C915Y	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	LLTPVKS	DEG_SCF_FBW7_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULL1	Pleckstrin homology domain-containing family G member 1	DEG_SCF_FBW7_1	899:905	LLTPVKS	FBXW7	0.9535	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons