DegronMD

Uniprot ID: Q9ULL1

Source protein: Pleckstrin homology domain-containing family G member 1

Source gene: PLEKHG1

Class: LIG_APCC_ABBA_1

Location: 1344:1349

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9991

ASA_SCORE: 78.9

COIL: 0.8762

CONS_SCORE: 0.2959

DSS_SCORE: 0.392

HELIX: 0.0693

FCONS_SCORE: 0.9913

RIG_SCORE: 0.738

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1344M	TCGA-04-1649	OV	TCGA	LTPYND	LIG_APCC_ABBA_1	0.5999
p.L1344M	DO32467	OV	ICGC	LTPYND	LIG_APCC_ABBA_1	0.5999
p.L1357H	TCGA-22-1005	LUSC	TCGA	LTPYND	LIG_APCC_ABBA_1	0.1111
p.L1357H	DO26632	LUSC	ICGC	LTPYND	LIG_APCC_ABBA_1	0.1111
p.V1334D	TCGA-56-A62T	LUSC	TCGA	LTPYND	LIG_APCC_ABBA_1	0.0556
p.V1334D	TCGA-UF-A7JT	HNSC	TCGA	LTPYND	LIG_APCC_ABBA_1	0.0556
p.V1334D	DO219090	HNSC	ICGC	LTPYND	LIG_APCC_ABBA_1	0.0556
p.V1334D	DO219144	LUSC	ICGC	LTPYND	LIG_APCC_ABBA_1	0.0556
p.L1357R	TCGA-DD-A1EE	LIHC	TCGA	LTPYND	LIG_APCC_ABBA_1	0.1111
p.L1357R	TCGA-EP-A26S	LIHC	TCGA	LTPYND	LIG_APCC_ABBA_1	0.1111
p.L1357R	DO22857	LIHC	ICGC	LTPYND	LIG_APCC_ABBA_1	0.1111
p.L1357R	DO22854	LIHC	ICGC	LTPYND	LIG_APCC_ABBA_1	0.1111
p.N1348T	TCGA-F5-6814	READ	TCGA	LTPYND	LIG_APCC_ABBA_1	0.5944
p.N1348T	DO36556	READ	ICGC	LTPYND	LIG_APCC_ABBA_1	0.5944
p.G1339C	DO229036	LICA	ICGC	LTPYND	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULL1	Pleckstrin homology domain-containing family G member 1	LIG_APCC_ABBA_1	1344:1349	LTPYND	APC,CDC20,FZR1	0.9991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons