DegronMD

Uniprot ID: Q8WZ75

Source protein: Roundabout homolog 4

Source gene: ROBO4

Class: DEG_SCF_FBW7_1

Location: 943:950

E3 ligase: FBXW7

DEGRON score: 0.936

ASA_SCORE: 66.1

COIL: 0.8183

CONS_SCORE: 0.5018

DSS_SCORE: 0.2686

HELIX: 0.1053

FCONS_SCORE: 0.7345

RIG_SCORE: 0.8009

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W954C	TCGA-EE-A2MD	SKCM	TCGA	IFLTPNLS	DEG_SCF_FBW7_1	0.2222
p.P952T	TCGA-KK-A8ID	PRAD	TCGA	IFLTPNLS	DEG_SCF_FBW7_1	0.2778
p.R940W	SIDM00499	Prostate Carcinoma	GDSC	IFLTPNLS	DEG_SCF_FBW7_1	0.25
p.R940W	ACH-000956	Prostate Cancer	CCLE	IFLTPNLS	DEG_SCF_FBW7_1	0.25
p.R940W	22RV1	prostate	COSMIC	IFLTPNLS	DEG_SCF_FBW7_1	0.25
p.D941V	SIDM00043	Head and Neck Carcinoma	GDSC	IFLTPNLS	DEG_SCF_FBW7_1	0.2778
p.D941V	SIDM00709	Non-Small Cell Lung Carcinoma	GDSC	IFLTPNLS	DEG_SCF_FBW7_1	0.2778
p.D941V	SIDM00115	Head and Neck Carcinoma	GDSC	IFLTPNLS	DEG_SCF_FBW7_1	0.2778
p.D941V	ACH-001148	Lymphoma	CCLE	IFLTPNLS	DEG_SCF_FBW7_1	0.2778
p.D941V	ACH-002297	Head and Neck Cancer	CCLE	IFLTPNLS	DEG_SCF_FBW7_1	0.2778
p.D941V	ACH-002298	Head and Neck Cancer	CCLE	IFLTPNLS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WZ75	Roundabout homolog 4	DEG_SCF_FBW7_1	943:950	IFLTPNLS	FBXW7	0.936	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons