DegronMD

Uniprot ID: Q92794

Source protein: Histone acetyltransferase KAT6A

Source gene: KAT6A

Class: CBL_PTK

Location: 1765:1775

E3 ligase: CBL

DEGRON score: 0.7983

ASA_SCORE: 87.4545

COIL: 0.8284

CONS_SCORE: 0.358

DSS_SCORE: 0.4007

HELIX: 0.1606

FCONS_SCORE: 0.9646

RIG_SCORE: 0.7043

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1775L	TCGA-A2-A0CM	BRCA	TCGA	DPHAMPYSHSP	CBL_PTK	0.7582
p.P1775L	DO5682	BRCA	ICGC	DPHAMPYSHSP	CBL_PTK	0.7582
p.A1776D	TCGA-A5-A1OF	UCEC	TCGA	DPHAMPYSHSP	CBL_PTK	0.3056
p.A1776D	DO42568	UCEC	ICGC	DPHAMPYSHSP	CBL_PTK	0.3056
p.Q1757H	TCGA-AX-A1CE	UCEC	TCGA	DPHAMPYSHSP	CBL_PTK	0.1111
p.Q1757H	DO42280	UCEC	ICGC	DPHAMPYSHSP	CBL_PTK	0.1111
p.V1784A	TCGA-B5-A0JY	UCEC	TCGA	DPHAMPYSHSP	CBL_PTK	0.0833
p.V1784A	DO43041	UCEC	ICGC	DPHAMPYSHSP	CBL_PTK	0.0833
p.T1778N	TCGA-BP-5181	KIRC	TCGA	DPHAMPYSHSP	CBL_PTK	0.25
p.T1778N	DO17263	KIRC	ICGC	DPHAMPYSHSP	CBL_PTK	0.25
p.S1772N	TCGA-BR-4184	STAD	TCGA	DPHAMPYSHSP	CBL_PTK	0.7069
p.S1772N	DO38328	STAD	ICGC	DPHAMPYSHSP	CBL_PTK	0.7069
p.S1779F	TCGA-EE-A2MD	SKCM	TCGA	DPHAMPYSHSP	CBL_PTK	0.2222
p.S1779F	DO222434	MELA	ICGC	DPHAMPYSHSP	CBL_PTK	0.2222
p.S1779F	DO37851	SKCM	ICGC	DPHAMPYSHSP	CBL_PTK	0.2222
p.S1779F	SIDM00545	Melanoma	GDSC	DPHAMPYSHSP	CBL_PTK	0.2222
p.S1779F	ACH-000987	Skin Cancer	CCLE	DPHAMPYSHSP	CBL_PTK	0.2222
p.S1779F	Mewo	skin	COSMIC	DPHAMPYSHSP	CBL_PTK	0.2222
p.V1784G	TCGA-EO-A3AV	UCEC	TCGA	DPHAMPYSHSP	CBL_PTK	0.0833
p.V1784G	DO52412	UCEC	ICGC	DPHAMPYSHSP	CBL_PTK	0.0833
p.V1784G	SIDM01310	Esophageal Carcinoma	GDSC	DPHAMPYSHSP	CBL_PTK	0.0833
p.P1770T	DO229008	LICA	ICGC	DPHAMPYSHSP	CBL_PTK	0.5919
p.S1783T	SIDM00199	Chondrosarcoma	GDSC	DPHAMPYSHSP	CBL_PTK	0.1111
p.S1783T	ACH-002099	Bone Cancer	CCLE	DPHAMPYSHSP	CBL_PTK	0.1111
p.S1783T	CS1	bone	COSMIC	DPHAMPYSHSP	CBL_PTK	0.1111
p.Y1780C	SIDM00876	Non-Cancerous	GDSC	DPHAMPYSHSP	CBL_PTK	0.1944
p.Y1780C	SIDM00877	Breast Carcinoma	GDSC	DPHAMPYSHSP	CBL_PTK	0.1944
p.Y1780C	ACH-000196	Breast Cancer	CCLE	DPHAMPYSHSP	CBL_PTK	0.1944
p.Y1780C	ACH-002374	Non-Cancerous	CCLE	DPHAMPYSHSP	CBL_PTK	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92794	Histone acetyltransferase KAT6A	CBL_PTK	1765:1775	DPHAMPYSHSP	CBL	0.7983	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DPHAMPYSHSP

Degron related mutations and impact score

Drug responses associated with KAT6A mutations

All proteins holding degron of DPHAMPYSHSP