DegronMD - P98177(FOXO4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A250T	TCGA-AP-A051	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1111
p.D469Y	TCGA-AP-A056	UCEC	TCGA	PVLTPPTE	DEG_SCF_FBW7_2	452:459	Mutation rewiring degron network	0.0556
p.A448D	TCGA-CA-6717	COAD	TCGA	LGTPVLT	DEG_SCF_FBW7_1	449:455	Mutation rewiring degron network	0.3056
p.A448D	TCGA-CA-6717	COAD	TCGA	PVLTPPTE	DEG_SCF_FBW7_2	452:459	Mutation rewiring degron network	0.2222
p.A460S	TCGA-EE-A2GN	SKCM	TCGA	LGTPVLT	DEG_SCF_FBW7_1	449:455	Mutation rewiring degron network	0.1944
p.A460S	TCGA-EE-A2GN	SKCM	TCGA	PVLTPPTE	DEG_SCF_FBW7_2	452:459	Mutation rewiring degron network	0.3056
p.P446L	TCGA-EE-A2M5	SKCM	TCGA	LGTPVLT	DEG_SCF_FBW7_1	449:455	Mutation rewiring degron network	0.25
p.P446L	TCGA-EE-A2M5	SKCM	TCGA	PVLTPPTE	DEG_SCF_FBW7_2	452:459	Mutation rewiring degron network	0.1667
p.S267R	DO5507	BRCA	ICGC	PRSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1944
p.R266W	DO9772	COAD	ICGC	PRSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.2222
p.R266W	DO43306	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.2222
p.R266W	DO43186	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.2222
p.P450L	DO50382	ESAD	ICGC	LGTPVLT	DEG_SCF_FBW7_1	449:455	Mutation altering degron motif	0.7582
p.G441E	DO50970	LICA	ICGC	LGTPVLT	DEG_SCF_FBW7_1	449:455	Mutation rewiring degron network	0.1111
p.G248V	DO24830	LUAD	ICGC	PRSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.0556
p.G248V	DO50673	ORCA	ICGC	PRSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.0556
p.G248V	DO219982	SARC	ICGC	PRSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.0556
p.L257V	DO26590	LUSC	ICGC	PRSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.3056
p.L264I	DO232761	PBCA	ICGC	PRSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.2778
p.S270T	DO42665	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.1111
p.R257H	SIDM00648	Small Cell Lung Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.3056
p.R257H	ACH-002169	Lung Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.3056
p.R257H	NCI-H1304	lung	COSMIC	PRSSS	DEG_SPOP_SBC_1	258:262	Mutation rewiring degron network	0.3056
p.T458A	SIDM01045	Endometrial Carcinoma	GDSC	PVLTPPTE	DEG_SCF_FBW7_2	452:459	Mutation altering degron motif	0.7139
p.T458A	ACH-000978	Endometrial/Uterine Cancer	CCLE	PVLTPPTE	DEG_SCF_FBW7_2	452:459	Mutation altering degron motif	0.7139
p.T458A	EN	endometrium	COSMIC	PVLTPPTE	DEG_SCF_FBW7_2	452:459	Mutation altering degron motif	0.7139
p.T455I	SIDM00999	Bladder Carcinoma	GDSC	LGTPVLT	DEG_SCF_FBW7_1	449:455	Mutation altering degron motif	0.8189
p.T455I	SIDM00999	Bladder Carcinoma	GDSC	PVLTPPTE	DEG_SCF_FBW7_2	452:459	Mutation altering degron motif	0.8189
p.T455I	ACH-000973	Bladder Cancer	CCLE	LGTPVLT	DEG_SCF_FBW7_1	449:455	Mutation altering degron motif	0.8189
p.T455I	ACH-000973	Bladder Cancer	CCLE	PVLTPPTE	DEG_SCF_FBW7_2	452:459	Mutation altering degron motif	0.8189
p.T455I	639-V	urinary tract	COSMIC	LGTPVLT	DEG_SCF_FBW7_1	449:455	Mutation altering degron motif	0.8189
p.T455I	639-V	urinary tract	COSMIC	PVLTPPTE	DEG_SCF_FBW7_2	452:459	Mutation altering degron motif	0.8189
p.Q463H	SIDM01690	Plasma Cell Myeloma	GDSC	LGTPVLT	DEG_SCF_FBW7_1	449:455	Mutation rewiring degron network	0.1111
p.Q463H	SIDM01690	Plasma Cell Myeloma	GDSC	PVLTPPTE	DEG_SCF_FBW7_2	452:459	Mutation rewiring degron network	0.2222
p.Q463H	ACH-000453	Myeloma	CCLE	LGTPVLT	DEG_SCF_FBW7_1	449:455	Mutation rewiring degron network	0.1111
p.Q463H	ACH-000453	Myeloma	CCLE	PVLTPPTE	DEG_SCF_FBW7_2	452:459	Mutation rewiring degron network	0.2222

Kaplan plot for FOXO4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FOXO4

UniProt ID: P98177

Entrez ID: 4303

Protein name: Forkhead box protein O4 (Fork head domain transcription factor AFX1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FOXO4 in