DegronMD

Uniprot ID: P98177

Source protein: Forkhead box protein O4

Source gene: FOXO4

Class: DEG_SCF_FBW7_2

Location: 452:459

E3 ligase: FBXW7

DEGRON score: 0.9408

ASA_SCORE: 86.8625

COIL: 0.8786

CONS_SCORE: 0.4024

DSS_SCORE: 0.6066

HELIX: 0.0669

FCONS_SCORE: 0.9785

RIG_SCORE: 0.6818

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D469Y	TCGA-AP-A056	UCEC	TCGA	PVLTPPTE	DEG_SCF_FBW7_2	0.0556
p.A448D	TCGA-CA-6717	COAD	TCGA	PVLTPPTE	DEG_SCF_FBW7_2	0.2222
p.A460S	TCGA-EE-A2GN	SKCM	TCGA	PVLTPPTE	DEG_SCF_FBW7_2	0.3056
p.P446L	TCGA-EE-A2M5	SKCM	TCGA	PVLTPPTE	DEG_SCF_FBW7_2	0.1667
p.T458A	SIDM01045	Endometrial Carcinoma	GDSC	PVLTPPTE	DEG_SCF_FBW7_2	0.7139
p.T458A	ACH-000978	Endometrial/Uterine Cancer	CCLE	PVLTPPTE	DEG_SCF_FBW7_2	0.7139
p.T458A	EN	endometrium	COSMIC	PVLTPPTE	DEG_SCF_FBW7_2	0.7139
p.T455I	SIDM00999	Bladder Carcinoma	GDSC	PVLTPPTE	DEG_SCF_FBW7_2	0.8189
p.T455I	ACH-000973	Bladder Cancer	CCLE	PVLTPPTE	DEG_SCF_FBW7_2	0.8189
p.T455I	639-V	urinary_tract	COSMIC	PVLTPPTE	DEG_SCF_FBW7_2	0.8189
p.Q463H	SIDM01690	Plasma Cell Myeloma	GDSC	PVLTPPTE	DEG_SCF_FBW7_2	0.2222
p.Q463H	ACH-000453	Myeloma	CCLE	PVLTPPTE	DEG_SCF_FBW7_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98177	Forkhead box protein O4	DEG_SCF_FBW7_2	452:459	PVLTPPTE	FBXW7	0.9408	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons