DegronMD

Uniprot ID: P98177

Source protein: Forkhead box protein O4

Source gene: FOXO4

Class: DEG_SCF_FBW7_1

Location: 449:455

E3 ligase: FBXW7

DEGRON score: 0.9964

ASA_SCORE: 83.3143

COIL: 0.9349

CONS_SCORE: 0.3925

DSS_SCORE: 0.5498

HELIX: 0.013

FCONS_SCORE: 1.0138

RIG_SCORE: 0.6688

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A448D	TCGA-CA-6717	COAD	TCGA	LGTPVLT	DEG_SCF_FBW7_1	0.3056
p.A460S	TCGA-EE-A2GN	SKCM	TCGA	LGTPVLT	DEG_SCF_FBW7_1	0.1944
p.P446L	TCGA-EE-A2M5	SKCM	TCGA	LGTPVLT	DEG_SCF_FBW7_1	0.25
p.P450L	DO50382	ESAD	ICGC	LGTPVLT	DEG_SCF_FBW7_1	0.7582
p.G441E	DO50970	LICA	ICGC	LGTPVLT	DEG_SCF_FBW7_1	0.1111
p.T455I	SIDM00999	Bladder Carcinoma	GDSC	LGTPVLT	DEG_SCF_FBW7_1	0.8189
p.T455I	ACH-000973	Bladder Cancer	CCLE	LGTPVLT	DEG_SCF_FBW7_1	0.8189
p.T455I	639-V	urinary_tract	COSMIC	LGTPVLT	DEG_SCF_FBW7_1	0.8189
p.Q463H	SIDM01690	Plasma Cell Myeloma	GDSC	LGTPVLT	DEG_SCF_FBW7_1	0.1111
p.Q463H	ACH-000453	Myeloma	CCLE	LGTPVLT	DEG_SCF_FBW7_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P98177	Forkhead box protein O4	DEG_SCF_FBW7_1	449:455	LGTPVLT	FBXW7	0.9964	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons