DegronMD - Q8TDI7(TMC2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S127L	TCGA-AP-A1DV	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1667
p.S127L	DO43186	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1667
p.H885R	TCGA-CV-5430	HNSC	TCGA	DSGHAPS	DEG_SCF_TRCP1_1	882:888	Mutation altering degron motif	0.7133
p.H885R	DO14270	HNSC	ICGC	DSGHAPS	DEG_SCF_TRCP1_1	882:888	Mutation altering degron motif	0.7133
p.S147F	TCGA-CV-7568	HNSC	TCGA	PRSSS	DEG_SPOP_SBC_1	133:137	Mutation blocking phosphorylation signal	0.5
p.S147F	DO14160	HNSC	ICGC	PRSSS	DEG_SPOP_SBC_1	133:137	Mutation blocking phosphorylation signal	0.5
p.G145V	TCGA-DK-A1AA	BLCA	TCGA	PRSSS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1111
p.G145V	DO548	BLCA	ICGC	PRSSS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1111
p.P892L	TCGA-DU-6392	LGG	TCGA	DSGHAPS	DEG_SCF_TRCP1_1	882:888	Mutation rewiring degron network	0.2222
p.P892L	DO22237	LGG	ICGC	DSGHAPS	DEG_SCF_TRCP1_1	882:888	Mutation rewiring degron network	0.2222
p.R129W	TCGA-EO-A22R	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.2222
p.R129W	DO233804	GACA	ICGC	PRSSS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.2222
p.R129W	DO42713	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.2222
p.S137T	TCGA-FI-A2D5	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	133:137	Mutation altering degron motif	0.6005
p.S137T	DO41331	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	133:137	Mutation altering degron motif	0.6005
p.Q889E	TCGA-FU-A3TX	CESC	TCGA	DSGHAPS	DEG_SCF_TRCP1_1	882:888	Mutation rewiring degron network	0.3056
p.Q889E	DO44281	CESC	ICGC	DSGHAPS	DEG_SCF_TRCP1_1	882:888	Mutation rewiring degron network	0.3056
p.R123K	DO229010	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.0556
p.R123K	DO229013	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.0556
p.R123K	DO229016	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.0556
p.R123K	DO229005	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.0556
p.R123K	DO231061	LUSC	ICGC	PRSSS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.0556
p.R123K	DO231007	LUSC	ICGC	PRSSS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.0556
p.R129Q	DO234205	ESAD	ICGC	PRSSS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.2222
p.R129Q	ACH-002026	Endometrial/Uterine Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.2222
p.G144C	DO228931	LICA	ICGC	PRSSS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1389
p.G880R	DO229054	LICA	ICGC	DSGHAPS	DEG_SCF_TRCP1_1	882:888	Mutation rewiring degron network	0.2778
p.E146K	DO220878	MELA	ICGC	PRSSS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.0833
p.S143C	DO46551	OV	ICGC	PRSSS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1667
p.R894M	DO46394	OV	ICGC	DSGHAPS	DEG_SCF_TRCP1_1	882:888	Mutation rewiring degron network	0.1667
p.S140F	SIDM00958	Chronic Myelogenous Leukemia	GDSC	PRSSS	DEG_SPOP_SBC_1	133:137	Mutation blocking phosphorylation signal	0.6944
p.S140F	ACH-000920	Leukemia	CCLE	PRSSS	DEG_SPOP_SBC_1	133:137	Mutation blocking phosphorylation signal	0.6944
p.S140F	CML-T1	haematopoietic and lymphoid tissue	COSMIC	PRSSS	DEG_SPOP_SBC_1	133:137	Mutation blocking phosphorylation signal	0.6944
p.D882Y	SIDM00783	Colorectal Carcinoma	GDSC	DSGHAPS	DEG_SCF_TRCP1_1	882:888	Mutation altering degron motif	0.7325
p.D882Y	ACH-000971	Colon/Colorectal Cancer	CCLE	DSGHAPS	DEG_SCF_TRCP1_1	882:888	Mutation altering degron motif	0.7325
p.D882Y	HCT-116	large intestine	COSMIC	DSGHAPS	DEG_SCF_TRCP1_1	882:888	Mutation altering degron motif	0.7325
p.A886T	ACH-000939	Sarcoma	CCLE	DSGHAPS	DEG_SCF_TRCP1_1	882:888	Mutation altering degron motif	0.6028
p.A886T	SK-UT-1	soft tissue	COSMIC	DSGHAPS	DEG_SCF_TRCP1_1	882:888	Mutation altering degron motif	0.6028
p.G145E	ACH-001111	Lymphoma	CCLE	PRSSS	DEG_SPOP_SBC_1	133:137	Mutation rewiring degron network	0.1111
p.S895A	ACH-002254	Lymphoma	CCLE	DSGHAPS	DEG_SCF_TRCP1_1	882:888	Mutation rewiring degron network	0.1389
p.S895A	KARPAS-1106P	haematopoietic and lymphoid tissue	COSMIC	DSGHAPS	DEG_SCF_TRCP1_1	882:888	Mutation rewiring degron network	0.1389

Kaplan plot for TMC2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TMC2

UniProt ID: Q8TDI7

Entrez ID: 117532

Protein name: Transmembrane channel-like protein 2 (Transmembrane cochlear-expressed protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TMC2 in