DegronMD

Uniprot ID: Q8TDI7

Source protein: Transmembrane channel-like protein 2

Source gene: TMC2

Class: DEG_SPOP_SBC_1

Location: 133:137

E3 ligase: SPOP

DEGRON score: 0.9412

ASA_SCORE: 94.22

COIL: 0.8154

CONS_SCORE: 0.3429

DSS_SCORE: 0.7052

HELIX: 0.136

FCONS_SCORE: 1.0131

RIG_SCORE: 0.5521

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S140F	SIDM00958	Chronic Myelogenous Leukemia	GDSC	PRSSS	DEG_SPOP_SBC_1	0.6944
p.S140F	ACH-000920	Leukemia	CCLE	PRSSS	DEG_SPOP_SBC_1	0.6944
p.S140F	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PRSSS	DEG_SPOP_SBC_1	0.6944
p.S137T	TCGA-FI-A2D5	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	0.6005
p.S137T	DO41331	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	0.6005
p.S147F	TCGA-CV-7568	HNSC	TCGA	PRSSS	DEG_SPOP_SBC_1	0.5
p.S147F	DO14160	HNSC	ICGC	PRSSS	DEG_SPOP_SBC_1	0.5
p.R129W	TCGA-EO-A22R	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	0.2222
p.R129W	DO233804	GACA	ICGC	PRSSS	DEG_SPOP_SBC_1	0.2222
p.R129W	DO42713	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	0.2222
p.R129Q	DO234205	ESAD	ICGC	PRSSS	DEG_SPOP_SBC_1	0.2222
p.R129Q	ACH-002026	Endometrial/Uterine Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	0.2222
p.S127L	TCGA-AP-A1DV	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	0.1667
p.S127L	DO43186	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	0.1667
p.S143C	DO46551	OV	ICGC	PRSSS	DEG_SPOP_SBC_1	0.1667
p.G144C	DO228931	LICA	ICGC	PRSSS	DEG_SPOP_SBC_1	0.1389
p.G145V	TCGA-DK-A1AA	BLCA	TCGA	PRSSS	DEG_SPOP_SBC_1	0.1111
p.G145V	DO548	BLCA	ICGC	PRSSS	DEG_SPOP_SBC_1	0.1111
p.G145E	ACH-001111	Lymphoma	CCLE	PRSSS	DEG_SPOP_SBC_1	0.1111
p.E146K	DO220878	MELA	ICGC	PRSSS	DEG_SPOP_SBC_1	0.0833
p.R123K	DO229010	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	0.0556
p.R123K	DO229013	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	0.0556
p.R123K	DO229016	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	0.0556
p.R123K	DO229005	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	0.0556
p.R123K	DO231061	LUSC	ICGC	PRSSS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 25 of 26 entries

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Drug responses associated with TMC2 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PRSSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5SQI0	Alpha-tubulin N-acetyltransferase 1	DEG_SPOP_SBC_1	268:272	PRSSS	SPOP	0.9882	More...
Q86UU0	B-cell CLL/lymphoma 9-like protein	DEG_SPOP_SBC_1	1049:1053	PRSSS	SPOP	0.9955	More...
P41182	B-cell lymphoma 6 protein	DEG_SPOP_SBC_1	458:462	PRSSS	SPOP	0.5537	More...
Q9NYF8	Bcl-2-associated transcription factor 1	DEG_SPOP_SBC_1	139:143	PRSSS	SPOP	0.9945	More...
Q9UQB8	Brain-specific angiogenesis inhibitor 1-associated protein 2	DEG_SPOP_SBC_1	362:366	PRSSS	SPOP	0.9997	More...
Q9HCK8	Chromodomain-helicase-DNA-binding protein 8	DEG_SPOP_SBC_1	2216:2220	PRSSS	SPOP	0.9419	More...
Q9P218	Collagen alpha-1	DEG_SPOP_SBC_1	1019:1023	PRSSS	SPOP	0.8033	More...
P49619	Diacylglycerol kinase gamma	DEG_SPOP_SBC_1	149:153	PRSSS	SPOP	0.5556	More...
Q9H992	E3 ubiquitin-protein ligase MARCHF7	DEG_SPOP_SBC_1	125:129	PRSSS	SPOP	0.8611	More...
O75592	E3 ubiquitin-protein ligase MYCBP2	DEG_SPOP_SBC_1	2840:2844	PRSSS	SPOP	0.9962	More...
Q5CZC0	Fibrous sheath-interacting protein 2	DEG_SPOP_SBC_1	4128:4132	PRSSS	SPOP	0.709	More...
P98177	Forkhead box protein O4	DEG_SPOP_SBC_1	258:262	PRSSS	SPOP	0.9997	More...
Q92794	Histone acetyltransferase KAT6A	DEG_SPOP_SBC_1	997:1001	PRSSS	SPOP	0.8724	More...
Q13478	Interleukin-18 receptor 1	DEG_SPOP_SBC_1	70:74	PRSSS	SPOP	0.7325	More...
P78386	Keratin, type II cuticular Hb5	DEG_SPOP_SBC_1	491:495	PRSSS	SPOP	0.8473	More...
Q8NEM0	Microcephalin	DEG_SPOP_SBC_1	349:353	PRSSS	SPOP	0.9918	More...
Q86TC9	Myopalladin	DEG_SPOP_SBC_1	588:592	PRSSS	SPOP	0.7566	More...
P55201	Peregrin	DEG_SPOP_SBC_1	995:999	PRSSS	SPOP	0.9038	More...
Q13515	Phakinin	DEG_SPOP_SBC_1	30:34	PRSSS	SPOP	0.9701	More...
O75081	Protein CBFA2T3	DEG_SPOP_SBC_1	455:459	PRSSS	SPOP	0.6229	More...
Q8NE31	Protein FAM13C	DEG_SPOP_SBC_1	269:273	PRSSS	SPOP	0.9952	More...
Q5JSZ5	Protein PRRC2B	DEG_SPOP_SBC_1	922:926	PRSSS	SPOP	0.8891	More...
O94964	Protein SOGA1	DEG_SPOP_SBC_1	1168:1172	PRSSS	SPOP	0.9994	More...
Q8N2C7	Protein unc-80 homolog	DEG_SPOP_SBC_1	381:385	PRSSS	SPOP	0.9941	More...
Q17RH7	Putative protein TPRXL	DEG_SPOP_SBC_1	203:207	PRSSS	SPOP	0.7838	More...

Showing 1 to 25 of 38 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRSSS

Degron related mutations and impact score

Drug responses associated with TMC2 mutations

All proteins holding degron of PRSSS