DegronMD - Q9UK33(ZNF580)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P5L	TCGA-4Z-AA7Y	BLCA	TCGA	PRSSS	DEG_SPOP_SBC_1	11:15	Mutation blocking phosphorylation signal	0.6111
p.P5L	DO51867	BLCA	ICGC	PRSSS	DEG_SPOP_SBC_1	11:15	Mutation blocking phosphorylation signal	0.6111
p.P24T	TCGA-EE-A182	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.0833
p.P24T	DO37814	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.0833
p.S14F	TCGA-EE-A29D	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	11:15	Mutation altering degron motif	0.7982
p.S14F	DO38123	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	11:15	Mutation altering degron motif	0.7982
p.P21Q	TCGA-G7-6790	KIRP	TCGA	PRSSS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.1667
p.P21Q	DO20888	KIRP	ICGC	PRSSS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.1667
p.S13F	TCGA-XF-A9T5	BLCA	TCGA	PRSSS	DEG_SPOP_SBC_1	11:15	Mutation altering degron motif	0.9093
p.S13F	DO51925	BLCA	ICGC	PRSSS	DEG_SPOP_SBC_1	11:15	Mutation altering degron motif	0.9093
p.P6L	DO218333	BRCA	ICGC	PRSSS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.1944
p.P6S	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PRSSS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.1944
p.P6S	SIDM00223	Small Cell Lung Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.1944
p.A18V	SIDM00845	Burkitt's Lymphoma	GDSC	PRSSS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.25
p.A18V	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PRSSS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.25
p.A18V	ACH-000786	Lymphoma	CCLE	PRSSS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.25
p.A18V	ACH-000992	Head and Neck Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.25
p.R12G	SIDM00693	Bladder Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	11:15	Mutation altering degron motif	0.6457
p.R12G	ACH-000396	Bladder Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	11:15	Mutation altering degron motif	0.6457
p.R12G	J82	urinary tract	COSMIC	PRSSS	DEG_SPOP_SBC_1	11:15	Mutation altering degron motif	0.6457
p.L4P	SIDM00537	Colorectal Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.1389
p.L4P	ACH-000982	Colon/Colorectal Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.1389
p.L4P	ACH-001345	Colon/Colorectal Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.1389
p.L4P	GP5d	large intestine	COSMIC	PRSSS	DEG_SPOP_SBC_1	11:15	Mutation rewiring degron network	0.1389

Kaplan plot for ZNF580 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZNF580

UniProt ID: Q9UK33

Entrez ID: 51157

Protein name: Zinc finger protein 580 (LDL-induced EC protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZNF580 in