DegronMD - Q15431(SYCP1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K24Q	TCGA-04-1342	OV	TCGA	PRSSS	DEG_SPOP_SBC_1	13:17	Mutation substituting flanking lysine	0.25
p.K24Q	DO29548	OV	ICGC	PRSSS	DEG_SPOP_SBC_1	13:17	Mutation substituting flanking lysine	0.25
p.M951I	TCGA-34-2604	LUSC	TCGA	LTTPGST	DEG_SCF_FBW7_1	936:942	Mutation rewiring degron network	0.0833
p.M951I	DO26433	LUSC	ICGC	LTTPGST	DEG_SCF_FBW7_1	936:942	Mutation rewiring degron network	0.0833
p.R952P	TCGA-43-5668	LUSC	TCGA	LTTPGST	DEG_SCF_FBW7_1	936:942	Mutation rewiring degron network	0.0556
p.R952P	DO26608	LUSC	ICGC	LTTPGST	DEG_SCF_FBW7_1	936:942	Mutation rewiring degron network	0.0556
p.R952G	TCGA-55-8302	LUAD	TCGA	LTTPGST	DEG_SCF_FBW7_1	936:942	Mutation rewiring degron network	0.0556
p.R952G	DO45312	LUAD	ICGC	LTTPGST	DEG_SCF_FBW7_1	936:942	Mutation rewiring degron network	0.0556
p.S941F	TCGA-56-8622	LUSC	TCGA	LTTPGST	DEG_SCF_FBW7_1	936:942	Mutation altering degron motif	0.6871
p.S941F	TCGA-Z2-A8RT	SKCM	TCGA	LTTPGST	DEG_SCF_FBW7_1	936:942	Mutation altering degron motif	0.6871
p.S941F	DO45449	LUSC	ICGC	LTTPGST	DEG_SCF_FBW7_1	936:942	Mutation altering degron motif	0.6871
p.S941F	DO51301	SKCM	ICGC	LTTPGST	DEG_SCF_FBW7_1	936:942	Mutation altering degron motif	0.6871
p.A947D	TCGA-AX-A05Z	UCEC	TCGA	LTTPGST	DEG_SCF_FBW7_1	936:942	Mutation rewiring degron network	0.1944
p.A947D	DO40884	UCEC	ICGC	LTTPGST	DEG_SCF_FBW7_1	936:942	Mutation rewiring degron network	0.1944
p.A22E	TCGA-CN-6010	HNSC	TCGA	PRSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1944
p.A22E	DO14766	HNSC	ICGC	PRSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1944
p.R952W	TCGA-D1-A17Q	UCEC	TCGA	LTTPGST	DEG_SCF_FBW7_1	936:942	Mutation rewiring degron network	0.0556
p.R952W	DO41903	UCEC	ICGC	LTTPGST	DEG_SCF_FBW7_1	936:942	Mutation rewiring degron network	0.0556
p.V11I	TCGA-DC-6160	READ	TCGA	PRSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.2778
p.V11I	DO233884	GACA	ICGC	PRSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.2778
p.V11I	DO36391	READ	ICGC	PRSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.2778
p.R14I	TCGA-E6-A1LX	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	13:17	Mutation altering degron motif	0.6991
p.R14I	DO41020	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	13:17	Mutation altering degron motif	0.6991
p.L936V	TCGA-IN-A6RP	STAD	TCGA	LTTPGST	DEG_SCF_FBW7_1	936:942	Mutation altering degron motif	0.5654
p.L936V	DO51741	STAD	ICGC	LTTPGST	DEG_SCF_FBW7_1	936:942	Mutation altering degron motif	0.5654
p.P25L	TCGA-IQ-A6SH	HNSC	TCGA	PRSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1111
p.P25L	DO223268	HNSC	ICGC	PRSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1111
p.Q26E	TCGA-LP-A4AV	CESC	TCGA	PRSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.0833
p.Q26E	DO44275	CESC	ICGC	PRSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.0833
p.P939S	TCGA-YD-A9TA	SKCM	TCGA	LTTPGST	DEG_SCF_FBW7_1	936:942	Mutation altering degron motif	0.6752
p.P939S	DO219503	SKCM	ICGC	LTTPGST	DEG_SCF_FBW7_1	936:942	Mutation altering degron motif	0.6752
p.F7L	DO48386	BLCA	ICGC	PRSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1667
p.T928A	DO228659	LICA	ICGC	LTTPGST	DEG_SCF_FBW7_1	936:942	Mutation rewiring degron network	0.1111
p.S935F	DO222536	MELA	ICGC	LTTPGST	DEG_SCF_FBW7_1	936:942	Mutation rewiring degron network	0.3056
p.T937A	DO229248	THCA	ICGC	LTTPGST	DEG_SCF_FBW7_1	936:942	Mutation altering degron motif	0.7139
p.S18N	SIDM00935	Other Solid Cancers	GDSC	PRSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.3056
p.S18N	ACH-002091	Skin Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.3056
p.S18N	CAL-39	vulva	COSMIC	PRSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.3056
p.K931N	SIDM01045	Endometrial Carcinoma	GDSC	LTTPGST	DEG_SCF_FBW7_1	936:942	Mutation substituting flanking lysine	0.3056
p.K931N	EN	endometrium	COSMIC	LTTPGST	DEG_SCF_FBW7_1	936:942	Mutation substituting flanking lysine	0.3056
p.P6H	SIDM00905	Cervical Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	13:17	Mutation substituting flanking lysine	0.25
p.P6H	ACH-001334	Cervical Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	13:17	Mutation substituting flanking lysine	0.25
p.P6H	ACH-001335	Cervical Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	13:17	Mutation substituting flanking lysine	0.25
p.A22V	SIDM01618	B-Lymphoblastic Leukemia	GDSC	PRSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1944
p.A22V	ACH-000942	Leukemia	CCLE	PRSSS	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1944
p.A932V	NUGC-3	stomach	COSMIC	LTTPGST	DEG_SCF_FBW7_1	936:942	Mutation rewiring degron network	0.2222
p.D938G	SNU-C5	large intestine	COSMIC	LTTPGST	DEG_SCF_FBW7_1	936:942	Mutation altering degron motif	0.7198

Kaplan plot for SYCP1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SYCP1

UniProt ID: Q15431

Entrez ID: 6847

Protein name: Synaptonemal complex protein 1 (SCP-1) (Cancer/testis antigen 8) (CT8)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SYCP1 in