DegronMD

Uniprot ID: Q15431

Source protein: Synaptonemal complex protein 1

Source gene: SYCP1

Class: DEG_SCF_FBW7_1

Location: 936:942

E3 ligase: FBXW7

DEGRON score: 0.9957

ASA_SCORE: 69.4714

COIL: 0.6713

CONS_SCORE: 0.4765

DSS_SCORE: 0.5018

HELIX: 0.1404

FCONS_SCORE: 1.0463

RIG_SCORE: 0.6919

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M951I	TCGA-34-2604	LUSC	TCGA	LTTPGST	DEG_SCF_FBW7_1	0.0833
p.M951I	DO26433	LUSC	ICGC	LTTPGST	DEG_SCF_FBW7_1	0.0833
p.R952P	TCGA-43-5668	LUSC	TCGA	LTTPGST	DEG_SCF_FBW7_1	0.0556
p.R952P	DO26608	LUSC	ICGC	LTTPGST	DEG_SCF_FBW7_1	0.0556
p.R952G	TCGA-55-8302	LUAD	TCGA	LTTPGST	DEG_SCF_FBW7_1	0.0556
p.R952G	DO45312	LUAD	ICGC	LTTPGST	DEG_SCF_FBW7_1	0.0556
p.S941F	TCGA-56-8622	LUSC	TCGA	LTTPGST	DEG_SCF_FBW7_1	0.6871
p.S941F	TCGA-Z2-A8RT	SKCM	TCGA	LTTPGST	DEG_SCF_FBW7_1	0.6871
p.S941F	DO45449	LUSC	ICGC	LTTPGST	DEG_SCF_FBW7_1	0.6871
p.S941F	DO51301	SKCM	ICGC	LTTPGST	DEG_SCF_FBW7_1	0.6871
p.A947D	TCGA-AX-A05Z	UCEC	TCGA	LTTPGST	DEG_SCF_FBW7_1	0.1944
p.A947D	DO40884	UCEC	ICGC	LTTPGST	DEG_SCF_FBW7_1	0.1944
p.R952W	TCGA-D1-A17Q	UCEC	TCGA	LTTPGST	DEG_SCF_FBW7_1	0.0556
p.R952W	DO41903	UCEC	ICGC	LTTPGST	DEG_SCF_FBW7_1	0.0556
p.L936V	TCGA-IN-A6RP	STAD	TCGA	LTTPGST	DEG_SCF_FBW7_1	0.5654
p.L936V	DO51741	STAD	ICGC	LTTPGST	DEG_SCF_FBW7_1	0.5654
p.P939S	TCGA-YD-A9TA	SKCM	TCGA	LTTPGST	DEG_SCF_FBW7_1	0.6752
p.P939S	DO219503	SKCM	ICGC	LTTPGST	DEG_SCF_FBW7_1	0.6752
p.T928A	DO228659	LICA	ICGC	LTTPGST	DEG_SCF_FBW7_1	0.1111
p.S935F	DO222536	MELA	ICGC	LTTPGST	DEG_SCF_FBW7_1	0.3056
p.T937A	DO229248	THCA	ICGC	LTTPGST	DEG_SCF_FBW7_1	0.7139
p.K931N	SIDM01045	Endometrial Carcinoma	GDSC	LTTPGST	DEG_SCF_FBW7_1	0.3056
p.K931N	EN	endometrium	COSMIC	LTTPGST	DEG_SCF_FBW7_1	0.3056
p.A932V	NUGC-3	stomach	COSMIC	LTTPGST	DEG_SCF_FBW7_1	0.2222
p.D938G	SNU-C5	large_intestine	COSMIC	LTTPGST	DEG_SCF_FBW7_1	0.7198

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15431	Synaptonemal complex protein 1	DEG_SCF_FBW7_1	936:942	LTTPGST	FBXW7	0.9957	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons