DegronMD - Q9Y4E6(WDR7)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G1161W	TCGA-49-AARQ	LUAD	TCGA	PRSSS	DEG_SPOP_SBC_1	1150:1154	Mutation rewiring degron network	0.1389
p.G1161W	TCGA-EE-A181	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	1150:1154	Mutation rewiring degron network	0.1389
p.A644G	TCGA-60-2725	LUSC	TCGA	TRRSLAALK	DEG_APCC_DBOX_1	633:641	Mutation rewiring degron network	0.25
p.A644G	DO26674	LUSC	ICGC	TRRSLAALK	DEG_APCC_DBOX_1	633:641	Mutation rewiring degron network	0.25
p.V626F	TCGA-77-7463	LUSC	TCGA	TRRSLAALK	DEG_APCC_DBOX_1	633:641	Mutation rewiring degron network	0.1389
p.V626F	DO26716	LUSC	ICGC	TRRSLAALK	DEG_APCC_DBOX_1	633:641	Mutation rewiring degron network	0.1389
p.P1144T	TCGA-85-6561	LUSC	TCGA	PRSSS	DEG_SPOP_SBC_1	1150:1154	Mutation rewiring degron network	0.1667
p.P1144T	DO26518	LUSC	ICGC	PRSSS	DEG_SPOP_SBC_1	1150:1154	Mutation rewiring degron network	0.1667
p.T926A	TCGA-DD-AADW	LIHC	TCGA	PSTPDLS	DEG_SCF_FBW7_1	924:930	Mutation altering degron motif	0.825
p.T926A	DO52249	LIHC	ICGC	PSTPDLS	DEG_SCF_FBW7_1	924:930	Mutation altering degron motif	0.825
p.P1157T	TCGA-EE-A181	SKCM	TCGA	PRSSS	DEG_SPOP_SBC_1	1150:1154	Mutation rewiring degron network	0.25
p.R1151Q	TCGA-ZF-AA54	BLCA	TCGA	PRSSS	DEG_SPOP_SBC_1	1150:1154	Mutation altering degron motif	0.6218
p.P624A	DO225334	BRCA	ICGC	TRRSLAALK	DEG_APCC_DBOX_1	633:641	Mutation rewiring degron network	0.0833
p.P1159H	DO10132	COAD	ICGC	PRSSS	DEG_SPOP_SBC_1	1150:1154	Mutation rewiring degron network	0.1944
p.K916N	DO8858	COAD	ICGC	PSTPDLS	DEG_SCF_FBW7_1	924:930	Mutation substituting flanking lysine	0.2222
p.K916N	SIDM00789	Colorectal Carcinoma	GDSC	PSTPDLS	DEG_SCF_FBW7_1	924:930	Mutation substituting flanking lysine	0.2222
p.K916N	ACH-000997	Colon/Colorectal Cancer	CCLE	PSTPDLS	DEG_SCF_FBW7_1	924:930	Mutation substituting flanking lysine	0.2222
p.K916N	ACH-001061	Colon/Colorectal Cancer	CCLE	PSTPDLS	DEG_SCF_FBW7_1	924:930	Mutation substituting flanking lysine	0.2222
p.K916N	HCT-15	large intestine	COSMIC	PSTPDLS	DEG_SCF_FBW7_1	924:930	Mutation substituting flanking lysine	0.2222
p.K1145Q	DO227994	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	1150:1154	Mutation substituting flanking lysine	0.3056
p.L1149I	DO222762	COCA	ICGC	PRSSS	DEG_SPOP_SBC_1	1150:1154	Mutation rewiring degron network	0.3056
p.K1144T	DO234230	ESAD	ICGC	PRSSS	DEG_SPOP_SBC_1	1150:1154	Mutation rewiring degron network	0.1667
p.R933K	DO48215	ESCA	ICGC	PSTPDLS	DEG_SCF_FBW7_1	924:930	Mutation rewiring degron network	0.25
p.R933K	DO48215	ESCA	ICGC	PPTSS	DEG_SPOP_SBC_1	936:940	Mutation rewiring degron network	0.25
p.K1157R	DO233686	GACA	ICGC	PRSSS	DEG_SPOP_SBC_1	1150:1154	Mutation rewiring degron network	0.25
p.G917C	DO228971	LICA	ICGC	PSTPDLS	DEG_SCF_FBW7_1	924:930	Mutation rewiring degron network	0.1389
p.S940I	DO228986	LICA	ICGC	PPTSS	DEG_SPOP_SBC_1	936:940	Mutation altering degron motif	0.8453
p.Q1155R	DO229177	LMS	ICGC	PRSSS	DEG_SPOP_SBC_1	1150:1154	Mutation rewiring degron network	0.3056
p.H1141R	DO48885	LUAD	ICGC	PRSSS	DEG_SPOP_SBC_1	1150:1154	Mutation rewiring degron network	0.0833
p.P1159S	DO220903	MELA	ICGC	PRSSS	DEG_SPOP_SBC_1	1150:1154	Mutation rewiring degron network	0.1944
p.L651F	DO222420	MELA	ICGC	TRRSLAALK	DEG_APCC_DBOX_1	633:641	Mutation rewiring degron network	0.0556
p.T1147M	DO51469	PACA	ICGC	PRSSS	DEG_SPOP_SBC_1	1150:1154	Mutation rewiring degron network	0.25
p.T1147M	DO42280	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	1150:1154	Mutation rewiring degron network	0.25
p.A644V	DO228839	PBCA	ICGC	TRRSLAALK	DEG_APCC_DBOX_1	633:641	Mutation rewiring degron network	0.25
p.Q949H	DO232224	PBCA	ICGC	PPTSS	DEG_SPOP_SBC_1	936:940	Mutation rewiring degron network	0.0833
p.P1150S	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	PRSSS	DEG_SPOP_SBC_1	1150:1154	Mutation altering degron motif	0.6752
p.P1150S	ACH-002313	Lymphoma	CCLE	PRSSS	DEG_SPOP_SBC_1	1150:1154	Mutation altering degron motif	0.6752
p.P1150S	TK	haematopoietic and lymphoid tissue	COSMIC	PRSSS	DEG_SPOP_SBC_1	1150:1154	Mutation altering degron motif	0.6752
p.T633S	SIDM00087	Plasma Cell Myeloma	GDSC	TRRSLAALK	DEG_APCC_DBOX_1	633:641	Mutation altering degron motif	0.6005
p.T633S	ACH-000817	Myeloma	CCLE	TRRSLAALK	DEG_APCC_DBOX_1	633:641	Mutation altering degron motif	0.6005
p.T633S	RPMI-8226	haematopoietic and lymphoid tissue	COSMIC	TRRSLAALK	DEG_APCC_DBOX_1	633:641	Mutation altering degron motif	0.6005
p.S939A	SIDM00060	Ovarian Carcinoma	GDSC	PPTSS	DEG_SPOP_SBC_1	936:940	Mutation altering degron motif	0.7588
p.A625S	SIDM00217	Colorectal Carcinoma	GDSC	TRRSLAALK	DEG_APCC_DBOX_1	633:641	Mutation rewiring degron network	0.1111
p.A625S	ACH-000999	Colon/Colorectal Cancer	CCLE	TRRSLAALK	DEG_APCC_DBOX_1	633:641	Mutation rewiring degron network	0.1111
p.A625S	SNU-1040	large intestine	COSMIC	TRRSLAALK	DEG_APCC_DBOX_1	633:641	Mutation rewiring degron network	0.1111
p.H646Y	SIDM01150	Non-Small Cell Lung Carcinoma	GDSC	TRRSLAALK	DEG_APCC_DBOX_1	633:641	Mutation rewiring degron network	0.1944
p.H646Y	ACH-000416	Lung Cancer	CCLE	TRRSLAALK	DEG_APCC_DBOX_1	633:641	Mutation rewiring degron network	0.1944
p.H646Y	NCI-H838	lung	COSMIC	TRRSLAALK	DEG_APCC_DBOX_1	633:641	Mutation rewiring degron network	0.1944
p.L1162F	SIDM00980	Gastric Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	1150:1154	Mutation rewiring degron network	0.1111
p.L1162F	ACH-000948	Gastric Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	1150:1154	Mutation rewiring degron network	0.1111
p.L1162F	23132-87	stomach	COSMIC	PRSSS	DEG_SPOP_SBC_1	1150:1154	Mutation rewiring degron network	0.1111
p.T650A	ACH-000068	Lymphoma	CCLE	TRRSLAALK	DEG_APCC_DBOX_1	633:641	Mutation blocking phosphorylation signal	0.5278
p.P936H	ACH-001061	Colon/Colorectal Cancer	CCLE	PPTSS	DEG_SPOP_SBC_1	936:940	Mutation altering degron motif	0.7694
p.L650F	HCT-15	large intestine	COSMIC	TRRSLAALK	DEG_APCC_DBOX_1	633:641	Mutation blocking phosphorylation signal	0.5278
p.S1162N	SNU-1040	large intestine	COSMIC	PRSSS	DEG_SPOP_SBC_1	1150:1154	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

WDR7

UniProt ID: Q9Y4E6

Entrez ID: 23335

Protein name: WD repeat-containing protein 7 (Rabconnectin-3 beta) (TGF-beta resistance-associated protein TRAG)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for WDR7 in