DegronMD

Uniprot ID: Q9Y4E6

Source protein: WD repeat-containing protein 7

Source gene: WDR7

Class: DEG_SCF_FBW7_1

Location: 924:930

E3 ligase: FBXW7

DEGRON score: 0.9974

ASA_SCORE: 77.9714

COIL: 0.8491

CONS_SCORE: 0.2867

DSS_SCORE: 0.8586

HELIX: 0.1256

FCONS_SCORE: 1.1506

RIG_SCORE: 0.6066

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T926A	TCGA-DD-AADW	LIHC	TCGA	PSTPDLS	DEG_SCF_FBW7_1	0.825
p.T926A	DO52249	LIHC	ICGC	PSTPDLS	DEG_SCF_FBW7_1	0.825
p.K916N	DO8858	COAD	ICGC	PSTPDLS	DEG_SCF_FBW7_1	0.2222
p.K916N	SIDM00789	Colorectal Carcinoma	GDSC	PSTPDLS	DEG_SCF_FBW7_1	0.2222
p.K916N	ACH-000997	Colon/Colorectal Cancer	CCLE	PSTPDLS	DEG_SCF_FBW7_1	0.2222
p.K916N	ACH-001061	Colon/Colorectal Cancer	CCLE	PSTPDLS	DEG_SCF_FBW7_1	0.2222
p.K916N	HCT-15	large_intestine	COSMIC	PSTPDLS	DEG_SCF_FBW7_1	0.2222
p.R933K	DO48215	ESCA	ICGC	PSTPDLS	DEG_SCF_FBW7_1	0.25
p.G917C	DO228971	LICA	ICGC	PSTPDLS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4E6	WD repeat-containing protein 7	DEG_SCF_FBW7_1	924:930	PSTPDLS	FBXW7	0.9974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons