DegronMD

Uniprot ID: Q9Y4E6

Source protein: WD repeat-containing protein 7

Source gene: WDR7

Class: DEG_APCC_DBOX_1

Location: 633:641

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7557

ASA_SCORE: 60.4889

COIL: 0.3757

CONS_SCORE: 0.2766

DSS_SCORE: 0.3585

HELIX: 0.2569

FCONS_SCORE: 0.9874

RIG_SCORE: 0.7751

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T633S	SIDM00087	Plasma Cell Myeloma	GDSC	TRRSLAALK	DEG_APCC_DBOX_1	0.6005
p.T633S	ACH-000817	Myeloma	CCLE	TRRSLAALK	DEG_APCC_DBOX_1	0.6005
p.T633S	RPMI-8226	haematopoietic_and_lymphoid_tissue	COSMIC	TRRSLAALK	DEG_APCC_DBOX_1	0.6005
p.T650A	ACH-000068	Lymphoma	CCLE	TRRSLAALK	DEG_APCC_DBOX_1	0.5278
p.L650F	HCT-15	large_intestine	COSMIC	TRRSLAALK	DEG_APCC_DBOX_1	0.5278
p.A644G	TCGA-60-2725	LUSC	TCGA	TRRSLAALK	DEG_APCC_DBOX_1	0.25
p.A644G	DO26674	LUSC	ICGC	TRRSLAALK	DEG_APCC_DBOX_1	0.25
p.A644V	DO228839	PBCA	ICGC	TRRSLAALK	DEG_APCC_DBOX_1	0.25
p.H646Y	SIDM01150	Non-Small Cell Lung Carcinoma	GDSC	TRRSLAALK	DEG_APCC_DBOX_1	0.1944
p.H646Y	ACH-000416	Lung Cancer	CCLE	TRRSLAALK	DEG_APCC_DBOX_1	0.1944
p.H646Y	NCI-H838	lung	COSMIC	TRRSLAALK	DEG_APCC_DBOX_1	0.1944
p.V626F	TCGA-77-7463	LUSC	TCGA	TRRSLAALK	DEG_APCC_DBOX_1	0.1389
p.V626F	DO26716	LUSC	ICGC	TRRSLAALK	DEG_APCC_DBOX_1	0.1389
p.A625S	SIDM00217	Colorectal Carcinoma	GDSC	TRRSLAALK	DEG_APCC_DBOX_1	0.1111
p.A625S	ACH-000999	Colon/Colorectal Cancer	CCLE	TRRSLAALK	DEG_APCC_DBOX_1	0.1111
p.A625S	SNU-1040	large_intestine	COSMIC	TRRSLAALK	DEG_APCC_DBOX_1	0.1111
p.P624A	DO225334	BRCA	ICGC	TRRSLAALK	DEG_APCC_DBOX_1	0.0833
p.L651F	DO222420	MELA	ICGC	TRRSLAALK	DEG_APCC_DBOX_1	0.0556

Showing 1 to 18 of 18 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4E6	WD repeat-containing protein 7	DEG_APCC_DBOX_1	633:641	TRRSLAALK	APC,CDC20,FZR1	0.7557	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons