DegronMD - O94964(SOGA1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A1227S	TCGA-18-5592	LUSC	TCGA	ARSTT	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.0833
p.A1227S	DO26432	LUSC	ICGC	ARSTT	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.0833
p.A1227S	ACH-001034	Bone Cancer	CCLE	ARSTT	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.0833
p.S1169F	TCGA-43-8116	LUSC	TCGA	PRSSS	DEG_SPOP_SBC_1	1168:1172	Mutation altering degron motif	0.7982
p.S1169F	DO27349	LUSC	ICGC	PRSSS	DEG_SPOP_SBC_1	1168:1172	Mutation altering degron motif	0.7982
p.S1169F	SIDM00149	Melanoma	GDSC	PRSSS	DEG_SPOP_SBC_1	1168:1172	Mutation altering degron motif	0.7982
p.S1169F	ACH-000750	Skin Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	1168:1172	Mutation altering degron motif	0.7982
p.S1169F	LOXIMVI	skin	COSMIC	PRSSS	DEG_SPOP_SBC_1	1168:1172	Mutation altering degron motif	0.7982
p.L1159V	TCGA-66-2758	LUSC	TCGA	PRSSS	DEG_SPOP_SBC_1	1168:1172	Mutation rewiring degron network	0.0833
p.L1159V	DO26731	LUSC	ICGC	PRSSS	DEG_SPOP_SBC_1	1168:1172	Mutation rewiring degron network	0.0833
p.R269C	TCGA-A5-A2K3	UCEC	TCGA	LRRHLQFVE	DEG_APCC_DBOX_1	274:282	Mutation rewiring degron network	0.1944
p.R269C	DO43899	UCEC	ICGC	LRRHLQFVE	DEG_APCC_DBOX_1	274:282	Mutation rewiring degron network	0.1944
p.I1276T	TCGA-A6-5665	COAD	TCGA	PPKY	ITCH	1284:1287	Mutation rewiring degron network	0.1111
p.I1276T	DO9756	COAD	ICGC	PPKY	ITCH	1284:1287	Mutation rewiring degron network	0.1111
p.D292A	TCGA-AA-3818	COAD	TCGA	LRRHLQFVE	DEG_APCC_DBOX_1	274:282	Mutation rewiring degron network	0.0556
p.D292A	DO7792	COAD	ICGC	LRRHLQFVE	DEG_APCC_DBOX_1	274:282	Mutation rewiring degron network	0.0556
p.R280H	TCGA-AA-3984	COAD	TCGA	LRRHLQFVE	DEG_APCC_DBOX_1	274:282	Mutation altering degron motif	0.8244
p.R280H	TCGA-D1-A174	UCEC	TCGA	LRRHLQFVE	DEG_APCC_DBOX_1	274:282	Mutation altering degron motif	0.8244
p.R280H	DO9002	COAD	ICGC	LRRHLQFVE	DEG_APCC_DBOX_1	274:282	Mutation altering degron motif	0.8244
p.R280H	DO40900	UCEC	ICGC	LRRHLQFVE	DEG_APCC_DBOX_1	274:282	Mutation altering degron motif	0.8244
p.R280H	SIDM00217	Colorectal Carcinoma	GDSC	LRRHLQFVE	DEG_APCC_DBOX_1	274:282	Mutation altering degron motif	0.8244
p.R280H	ACH-000999	Colon/Colorectal Cancer	CCLE	LRRHLQFVE	DEG_APCC_DBOX_1	274:282	Mutation altering degron motif	0.8244
p.R280H	SNU-1040	large intestine	COSMIC	LRRHLQFVE	DEG_APCC_DBOX_1	274:282	Mutation altering degron motif	0.8244
p.R1139C	TCGA-AA-A022	COAD	TCGA	VKSTS	DEG_SPOP_SBC_1	1127:1131	Mutation blocking phosphorylation signal	0.5556
p.R1139C	DO10647	COAD	ICGC	VKSTS	DEG_SPOP_SBC_1	1127:1131	Mutation blocking phosphorylation signal	0.5556
p.T1248M	TCGA-AD-6964	COAD	TCGA	ARSTT	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.1111
p.T1248M	DO8360	COAD	ICGC	ARSTT	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.1111
p.T1248M	ACH-001719	Ovarian Cancer	CCLE	ARSTT	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.1111
p.S1169Y	TCGA-AG-A023	READ	TCGA	PRSSS	DEG_SPOP_SBC_1	1168:1172	Mutation altering degron motif	0.712
p.S1169Y	DO36752	READ	ICGC	PRSSS	DEG_SPOP_SBC_1	1168:1172	Mutation altering degron motif	0.712
p.P1233L	TCGA-BR-8487	STAD	TCGA	ARSTT	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.25
p.S1164F	TCGA-C5-A8XJ	CESC	TCGA	PRSSS	DEG_SPOP_SBC_1	1168:1172	Mutation substituting flanking lysine	0.3333
p.S1173G	TCGA-CG-4477	STAD	TCGA	PRSSS	DEG_SPOP_SBC_1	1168:1172	Mutation rewiring degron network	0.3056
p.S1173G	DO38193	STAD	ICGC	PRSSS	DEG_SPOP_SBC_1	1168:1172	Mutation rewiring degron network	0.3056
p.P1245S	TCGA-CN-4731	HNSC	TCGA	ARSTT	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.1944
p.P1245S	DO15886	HNSC	ICGC	ARSTT	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.1944
p.R274W	TCGA-D1-A167	UCEC	TCGA	LRRHLQFVE	DEG_APCC_DBOX_1	274:282	Mutation altering degron motif	0.8634
p.R274W	DO40978	UCEC	ICGC	LRRHLQFVE	DEG_APCC_DBOX_1	274:282	Mutation altering degron motif	0.8634
p.G1158A	TCGA-VP-A87D	PRAD	TCGA	PRSSS	DEG_SPOP_SBC_1	1168:1172	Mutation rewiring degron network	0.0556
p.G1158A	DO51385	PRAD	ICGC	PRSSS	DEG_SPOP_SBC_1	1168:1172	Mutation rewiring degron network	0.0556
p.A286T	TCGA-ZC-AAAA	THYM	TCGA	LRRHLQFVE	DEG_APCC_DBOX_1	274:282	Mutation rewiring degron network	0.2222
p.K1286E	DO222260	ALL	ICGC	PPKY	ITCH	1284:1287	Mutation altering degron motif	0.591
p.R1240C	DO234337	ESAD	ICGC	ARSTT	DEG_SPOP_SBC_1	1236:1240	Mutation altering degron motif	0.8301
p.E279K	DO233731	GACA	ICGC	LRRHLQFVE	DEG_APCC_DBOX_1	274:282	Mutation altering degron motif	0.7022
p.A1118S	DO233874	GACA	ICGC	VKSTS	DEG_SPOP_SBC_1	1127:1131	Mutation rewiring degron network	0.0833
p.S1166Y	DO228917	LICA	ICGC	PRSSS	DEG_SPOP_SBC_1	1168:1172	Mutation rewiring degron network	0.2778
p.R1234L	DO232020	LICA	ICGC	ARSTT	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.2778
p.A264D	DO229028	LICA	ICGC	LRRHLQFVE	DEG_APCC_DBOX_1	274:282	Mutation rewiring degron network	0.0556
p.L1296M	DO229038	LICA	ICGC	PPKY	ITCH	1284:1287	Mutation rewiring degron network	0.0833
p.D1294N	DO229055	LICA	ICGC	PPKY	ITCH	1284:1287	Mutation rewiring degron network	0.1389
p.E1277K	DO45175	LIRI	ICGC	PPKY	ITCH	1284:1287	Mutation rewiring degron network	0.1389
p.I1250M	DO51518	PACA	ICGC	ARSTT	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.0556
p.T1162I	DO51494	PACA	ICGC	PRSSS	DEG_SPOP_SBC_1	1168:1172	Mutation rewiring degron network	0.1667
p.E279G	DO229253	THCA	ICGC	LRRHLQFVE	DEG_APCC_DBOX_1	274:282	Mutation altering degron motif	0.7199
p.C268Y	SIDM00373	Endometrial Carcinoma	GDSC	LRRHLQFVE	DEG_APCC_DBOX_1	274:282	Mutation rewiring degron network	0.1667
p.C268Y	ACH-000974	Endometrial/Uterine Cancer	CCLE	LRRHLQFVE	DEG_APCC_DBOX_1	274:282	Mutation rewiring degron network	0.1667
p.Q1231H	SIDM00406	B-Cell Non-Hodgkin's Lymphoma	GDSC	ARSTT	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.1944
p.Q1231H	SIDM00845	Burkitt's Lymphoma	GDSC	ARSTT	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.1944
p.Q1231H	SIDM00967	Ovarian Carcinoma	GDSC	ARSTT	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.1944
p.Q1231H	SIDM01126	Small Cell Lung Carcinoma	GDSC	ARSTT	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.1944
p.Q1231H	SIDM00656	Burkitt's Lymphoma	GDSC	ARSTT	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.1944
p.Q1231H	SIDM00210	Ovarian Carcinoma	GDSC	ARSTT	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.1944
p.Q1231H	SIDM01112	Osteosarcoma	GDSC	ARSTT	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.1944
p.Q1231H	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	ARSTT	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.1944
p.Q1231H	SIDM00930	Osteosarcoma	GDSC	ARSTT	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.1944
p.Q1231H	SIDM00720	Mesothelioma	GDSC	ARSTT	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.1944
p.Q1231H	SIDM01173	Rhabdomyosarcoma	GDSC	ARSTT	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.1944
p.Q1231H	SIDM00641	Burkitt's Lymphoma	GDSC	ARSTT	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.1944
p.D1176G	SIDM00216	Colorectal Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	1168:1172	Mutation rewiring degron network	0.2222
p.D1176G	ACH-000989	Colon/Colorectal Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	1168:1172	Mutation rewiring degron network	0.2222
p.D1176G	SNU-175	large intestine	COSMIC	PRSSS	DEG_SPOP_SBC_1	1168:1172	Mutation rewiring degron network	0.2222
p.R269H	SIDM00193	Colorectal Carcinoma	GDSC	LRRHLQFVE	DEG_APCC_DBOX_1	274:282	Mutation rewiring degron network	0.1944
p.R269H	ACH-000991	Colon/Colorectal Cancer	CCLE	LRRHLQFVE	DEG_APCC_DBOX_1	274:282	Mutation rewiring degron network	0.1944
p.R269H	SNU-81	large intestine	COSMIC	LRRHLQFVE	DEG_APCC_DBOX_1	274:282	Mutation rewiring degron network	0.1944
p.S1290L	SIDM00520	Mesothelioma	GDSC	PPKY	ITCH	1284:1287	Mutation rewiring degron network	0.25
p.G1249S	SIDM01113	Other Sarcomas	GDSC	ARSTT	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.0833
p.G1249S	SK-UT-1	soft tissue	COSMIC	ARSTT	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.0833
p.A1118V	SIDM00251	Gastric Carcinoma	GDSC	VKSTS	DEG_SPOP_SBC_1	1127:1131	Mutation rewiring degron network	0.0833
p.A1118V	TGBC11TKB	stomach	COSMIC	VKSTS	DEG_SPOP_SBC_1	1127:1131	Mutation rewiring degron network	0.0833
p.R284H	SIDM00429	B-Lymphoblastic Leukemia	GDSC	LRRHLQFVE	DEG_APCC_DBOX_1	274:282	Mutation rewiring degron network	0.2778
p.R284H	ACH-000938	Leukemia	CCLE	LRRHLQFVE	DEG_APCC_DBOX_1	274:282	Mutation rewiring degron network	0.2778
p.R284H	NALM-6	haematopoietic and lymphoid tissue	COSMIC	LRRHLQFVE	DEG_APCC_DBOX_1	274:282	Mutation rewiring degron network	0.2778
p.M1168T	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	1168:1172	Mutation altering degron motif	0.7423
p.M1168T	ACH-000852	Lung Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	1168:1172	Mutation altering degron motif	0.7423
p.M1168T	NCI-H1435	lung	COSMIC	PRSSS	DEG_SPOP_SBC_1	1168:1172	Mutation altering degron motif	0.7423
p.R1158C	ACH-000919	Gastric Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	1168:1172	Mutation rewiring degron network	0.0556
p.R1119C	ACH-000930	Breast Cancer	CCLE	VKSTS	DEG_SPOP_SBC_1	1127:1131	Mutation rewiring degron network	0.1111
p.T1134M	ACH-000943	Colon/Colorectal Cancer	CCLE	VKSTS	DEG_SPOP_SBC_1	1127:1131	Mutation blocking phosphorylation signal	0.6944
p.T1241M	ACH-000990	Endometrial/Uterine Cancer	CCLE	ARSTT	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.3056
p.P1234S	ACH-001551	Skin Cancer	CCLE	ARSTT	DEG_SPOP_SBC_1	1236:1240	Mutation rewiring degron network	0.2778
p.R290H	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	LRRHLQFVE	DEG_APCC_DBOX_1	274:282	Mutation rewiring degron network	0.1111
p.S292T	RKO	large intestine	COSMIC	LRRHLQFVE	DEG_APCC_DBOX_1	274:282	Mutation rewiring degron network	0.0556
p.R290C	MFE-319	endometrium	COSMIC	LRRHLQFVE	DEG_APCC_DBOX_1	274:282	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SOGA1

UniProt ID: O94964

Entrez ID: 140710

Protein name: Protein SOGA1 (SOGA family member 1) (Suppressor of glucose by autophagy) (Suppressor of glucose, autophagy-associated protein 1) [Cleaved into: N-terminal form; C-terminal 80 kDa form (80-kDa SOGA fragment)]

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SOGA1 in