DegronMD

Uniprot ID: O94964

Source protein: Protein SOGA1

Source gene: SOGA1

Class: DEG_APCC_DBOX_1

Location: 274:282

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5818

ASA_SCORE: 98.8

COIL: 0.0456

CONS_SCORE: 0.7725

DSS_SCORE: 0.2316

HELIX: 0.9553

FCONS_SCORE: 1.3009

RIG_SCORE: 0.8244

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R269C	TCGA-A5-A2K3	UCEC	TCGA	LRRHLQFVE	DEG_APCC_DBOX_1	0.1944
p.R269C	DO43899	UCEC	ICGC	LRRHLQFVE	DEG_APCC_DBOX_1	0.1944
p.D292A	TCGA-AA-3818	COAD	TCGA	LRRHLQFVE	DEG_APCC_DBOX_1	0.0556
p.D292A	DO7792	COAD	ICGC	LRRHLQFVE	DEG_APCC_DBOX_1	0.0556
p.R280H	TCGA-AA-3984	COAD	TCGA	LRRHLQFVE	DEG_APCC_DBOX_1	0.8244
p.R280H	TCGA-D1-A174	UCEC	TCGA	LRRHLQFVE	DEG_APCC_DBOX_1	0.8244
p.R280H	DO9002	COAD	ICGC	LRRHLQFVE	DEG_APCC_DBOX_1	0.8244
p.R280H	DO40900	UCEC	ICGC	LRRHLQFVE	DEG_APCC_DBOX_1	0.8244
p.R280H	SIDM00217	Colorectal Carcinoma	GDSC	LRRHLQFVE	DEG_APCC_DBOX_1	0.8244
p.R280H	ACH-000999	Colon/Colorectal Cancer	CCLE	LRRHLQFVE	DEG_APCC_DBOX_1	0.8244
p.R280H	SNU-1040	large_intestine	COSMIC	LRRHLQFVE	DEG_APCC_DBOX_1	0.8244
p.R274W	TCGA-D1-A167	UCEC	TCGA	LRRHLQFVE	DEG_APCC_DBOX_1	0.8634
p.R274W	DO40978	UCEC	ICGC	LRRHLQFVE	DEG_APCC_DBOX_1	0.8634
p.A286T	TCGA-ZC-AAAA	THYM	TCGA	LRRHLQFVE	DEG_APCC_DBOX_1	0.2222
p.E279K	DO233731	GACA	ICGC	LRRHLQFVE	DEG_APCC_DBOX_1	0.7022
p.A264D	DO229028	LICA	ICGC	LRRHLQFVE	DEG_APCC_DBOX_1	0.0556
p.E279G	DO229253	THCA	ICGC	LRRHLQFVE	DEG_APCC_DBOX_1	0.7199
p.C268Y	SIDM00373	Endometrial Carcinoma	GDSC	LRRHLQFVE	DEG_APCC_DBOX_1	0.1667
p.C268Y	ACH-000974	Endometrial/Uterine Cancer	CCLE	LRRHLQFVE	DEG_APCC_DBOX_1	0.1667
p.R269H	SIDM00193	Colorectal Carcinoma	GDSC	LRRHLQFVE	DEG_APCC_DBOX_1	0.1944
p.R269H	ACH-000991	Colon/Colorectal Cancer	CCLE	LRRHLQFVE	DEG_APCC_DBOX_1	0.1944
p.R269H	SNU-81	large_intestine	COSMIC	LRRHLQFVE	DEG_APCC_DBOX_1	0.1944
p.R284H	SIDM00429	B-Lymphoblastic Leukemia	GDSC	LRRHLQFVE	DEG_APCC_DBOX_1	0.2778
p.R284H	ACH-000938	Leukemia	CCLE	LRRHLQFVE	DEG_APCC_DBOX_1	0.2778
p.R284H	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	LRRHLQFVE	DEG_APCC_DBOX_1	0.2778
p.R290H	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	LRRHLQFVE	DEG_APCC_DBOX_1	0.1111
p.S292T	RKO	large_intestine	COSMIC	LRRHLQFVE	DEG_APCC_DBOX_1	0.0556
p.R290C	MFE-319	endometrium	COSMIC	LRRHLQFVE	DEG_APCC_DBOX_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94964	Protein SOGA1	DEG_APCC_DBOX_1	274:282	LRRHLQFVE	APC,CDC20,FZR1	0.5818	More...
Q9Y4B5	Microtubule cross-linking factor 1	DEG_APCC_DBOX_1	634:642	LRRHLQFVE	APC,CDC20,FZR1	0.9657	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LRRHLQFVE

Degron related mutations and impact score

Drug responses associated with SOGA1 mutations

All proteins holding degron of LRRHLQFVE