DegronMD

Uniprot ID: Q9Y4B5

Source protein: Microtubule cross-linking factor 1

Source gene: MTCL1

Class: DEG_APCC_DBOX_1

Location: 634:642

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9657

ASA_SCORE: 98.0444

COIL: 0.0183

CONS_SCORE: 0.6678

DSS_SCORE: 0.4262

HELIX: 0.9808

FCONS_SCORE: 1.3401

RIG_SCORE: 0.787

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R635H	NCI-H630	large_intestine	COSMIC	LRRHLQFVE	DEG_APCC_DBOX_1	0.8244
p.R640Q	JHH-4	liver	COSMIC	LRRHLQFVE	DEG_APCC_DBOX_1	0.7329
p.E643K	SNU-C5	large_intestine	COSMIC	LRRHLQFVE	DEG_APCC_DBOX_1	0.3056
p.G632A	IM-95	stomach	COSMIC	LRRHLQFVE	DEG_APCC_DBOX_1	0.2778
p.T632A	CAL-148	breast	COSMIC	LRRHLQFVE	DEG_APCC_DBOX_1	0.2778
p.R649W	CTB-1	haematopoietic_and_lymphoid_tissue	COSMIC	LRRHLQFVE	DEG_APCC_DBOX_1	0.1389

Showing 1 to 6 of 6 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y4B5	Microtubule cross-linking factor 1	DEG_APCC_DBOX_1	634:642	LRRHLQFVE	APC,CDC20,FZR1	0.9657	More...
O94964	Protein SOGA1	DEG_APCC_DBOX_1	274:282	LRRHLQFVE	APC,CDC20,FZR1	0.5818	More...

Showing 1 to 2 of 2 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons