DegronMD

Uniprot ID: O94964

Source protein: Protein SOGA1

Source gene: SOGA1

Class: DEG_SPOP_SBC_1

Location: 1236:1240

E3 ligase: SPOP

DEGRON score: 0.9985

ASA_SCORE: 76.68

COIL: 0.7562

CONS_SCORE: 0.6551

DSS_SCORE: 0.5318

HELIX: 0.097

FCONS_SCORE: 1.1887

RIG_SCORE: 0.7212

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1227S	TCGA-18-5592	LUSC	TCGA	ARSTT	DEG_SPOP_SBC_1	0.0833
p.A1227S	DO26432	LUSC	ICGC	ARSTT	DEG_SPOP_SBC_1	0.0833
p.A1227S	ACH-001034	Bone Cancer	CCLE	ARSTT	DEG_SPOP_SBC_1	0.0833
p.T1248M	TCGA-AD-6964	COAD	TCGA	ARSTT	DEG_SPOP_SBC_1	0.1111
p.T1248M	DO8360	COAD	ICGC	ARSTT	DEG_SPOP_SBC_1	0.1111
p.T1248M	ACH-001719	Ovarian Cancer	CCLE	ARSTT	DEG_SPOP_SBC_1	0.1111
p.P1233L	TCGA-BR-8487	STAD	TCGA	ARSTT	DEG_SPOP_SBC_1	0.25
p.P1245S	TCGA-CN-4731	HNSC	TCGA	ARSTT	DEG_SPOP_SBC_1	0.1944
p.P1245S	DO15886	HNSC	ICGC	ARSTT	DEG_SPOP_SBC_1	0.1944
p.R1240C	DO234337	ESAD	ICGC	ARSTT	DEG_SPOP_SBC_1	0.8301
p.R1234L	DO232020	LICA	ICGC	ARSTT	DEG_SPOP_SBC_1	0.2778
p.I1250M	DO51518	PACA	ICGC	ARSTT	DEG_SPOP_SBC_1	0.0556
p.Q1231H	SIDM00406	B-Cell Non-Hodgkin's Lymphoma	GDSC	ARSTT	DEG_SPOP_SBC_1	0.1944
p.Q1231H	SIDM00845	Burkitt's Lymphoma	GDSC	ARSTT	DEG_SPOP_SBC_1	0.1944
p.Q1231H	SIDM00967	Ovarian Carcinoma	GDSC	ARSTT	DEG_SPOP_SBC_1	0.1944
p.Q1231H	SIDM01126	Small Cell Lung Carcinoma	GDSC	ARSTT	DEG_SPOP_SBC_1	0.1944
p.Q1231H	SIDM00656	Burkitt's Lymphoma	GDSC	ARSTT	DEG_SPOP_SBC_1	0.1944
p.Q1231H	SIDM00210	Ovarian Carcinoma	GDSC	ARSTT	DEG_SPOP_SBC_1	0.1944
p.Q1231H	SIDM01112	Osteosarcoma	GDSC	ARSTT	DEG_SPOP_SBC_1	0.1944
p.Q1231H	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	ARSTT	DEG_SPOP_SBC_1	0.1944
p.Q1231H	SIDM00930	Osteosarcoma	GDSC	ARSTT	DEG_SPOP_SBC_1	0.1944
p.Q1231H	SIDM00720	Mesothelioma	GDSC	ARSTT	DEG_SPOP_SBC_1	0.1944
p.Q1231H	SIDM01173	Rhabdomyosarcoma	GDSC	ARSTT	DEG_SPOP_SBC_1	0.1944
p.Q1231H	SIDM00641	Burkitt's Lymphoma	GDSC	ARSTT	DEG_SPOP_SBC_1	0.1944
p.G1249S	SIDM01113	Other Sarcomas	GDSC	ARSTT	DEG_SPOP_SBC_1	0.0833
p.G1249S	SK-UT-1	soft_tissue	COSMIC	ARSTT	DEG_SPOP_SBC_1	0.0833
p.T1241M	ACH-000990	Endometrial/Uterine Cancer	CCLE	ARSTT	DEG_SPOP_SBC_1	0.3056
p.P1234S	ACH-001551	Skin Cancer	CCLE	ARSTT	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94964	Protein SOGA1	DEG_SPOP_SBC_1	1236:1240	ARSTT	SPOP	0.9985	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	818:822	ARSTT	SPOP	0.6179	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	927:931	ARSTT	SPOP	0.959	More...
Q9Y2N7	Hypoxia-inducible factor 3-alpha	DEG_SPOP_SBC_1	8:12	ARSTT	SPOP	0.7168	More...
A6NDY2	Putative protein FAM90A10	DEG_SPOP_SBC_1	54:58	ARSTT	SPOP	0.5218	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARSTT

Degron related mutations and impact score

Drug responses associated with SOGA1 mutations

All proteins holding degron of ARSTT