DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
ARSTT
Uniprot ID:
A6NDY2
Source protein:
Putative protein FAM90A10
Source gene:
FAM90A10
Class:
DEG_SPOP_SBC_1
Location:
54:58
E3 ligase:
SPOP
DEGRON score:
0.5218
ASA_SCORE:
78.14
COIL:
0.8034
CONS_SCORE:
0.6107
DSS_SCORE:
0.1452
HELIX:
0.0916
FCONS_SCORE:
0.7996
RIG_SCORE:
0.7498
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with FAM90A10 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ARSTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O94964
Protein SOGA1
DEG_SPOP_SBC_1
1236:1240
ARSTT
SPOP
0.9985
More...
Q9UKN1
Mucin-12
DEG_SPOP_SBC_1
818:822
ARSTT
SPOP
0.6179
More...
Q9UKN1
Mucin-12
DEG_SPOP_SBC_1
927:931
ARSTT
SPOP
0.959
More...
Q9Y2N7
Hypoxia-inducible factor 3-alpha
DEG_SPOP_SBC_1
8:12
ARSTT
SPOP
0.7168
More...
A6NDY2
Putative protein FAM90A10
DEG_SPOP_SBC_1
54:58
ARSTT
SPOP
0.5218
More...