DegronMD - Q9Y2N7(HIF3A)

FUNCTION: Acts as a transcriptional regulator in adaptive response to low oxygen tension. Acts as a regulator of hypoxia-inducible gene expression (PubMed:11573933, PubMed:16126907, PubMed:19694616, PubMed:20416395, PubMed:21069422). Functions as an inhibitor of angiogenesis in hypoxic cells of the cornea. Plays a role in the development of the cardiorespiratory system. May also be involved in apoptosis (By similarity). {ECO:0000250|UniProtKB:Q0VBL6, ECO:0000269|PubMed:11573933, ECO:0000269|PubMed:16126907, ECO:0000269|PubMed:19694616, ECO:0000269|PubMed:20416395, ECO:0000269|PubMed:21069422}.; FUNCTION: [Isoform 2]: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. Also inhibits hypoxia-inducible ARNT-mediated gene expression. {ECO:0000269|PubMed:11573933}.; FUNCTION: [Isoform 3]: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. {ECO:0000269|PubMed:19694616, ECO:0000269|PubMed:20416395, ECO:0000269|PubMed:21069422}.; FUNCTION: [Isoform 4]: Attenuates the ability of transcription factor HIF1A and EPAS1/HIF2A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation (PubMed:16126907, PubMed:17998805, PubMed:19694616, PubMed:20416395). May act as a tumor suppressor and inhibits malignant cell transformation (PubMed:17998805). {ECO:0000269|PubMed:16126907, ECO:0000269|PubMed:17998805, ECO:0000269|PubMed:19694616, ECO:0000269|PubMed:20416395}.; FUNCTION: [Isoform 5]: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. {ECO:0000269|PubMed:21069422}. View more >>

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D499G	TCGA-19-5959	GBM	TCGA	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation altering degron motif	0.6087
p.Q507K	TCGA-33-AASL	LUSC	TCGA	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation rewiring degron network	0.1944
p.P641H	TCGA-43-6143	LUSC	TCGA	LSPYSD	LIG_APCC_ABBA_1	644:649	Mutation rewiring degron network	0.25
p.D486Y	TCGA-55-7907	LUAD	TCGA	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation rewiring degron network	0.2222
p.E17K	TCGA-5L-AAT1	BRCA	TCGA	ARSTT	DEG_SPOP_SBC_1	8:12	Mutation rewiring degron network	0.1944
p.E17K	DO219594	BRCA	ICGC	ARSTT	DEG_SPOP_SBC_1	8:12	Mutation rewiring degron network	0.1944
p.R510G	TCGA-95-7043	LUAD	TCGA	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation rewiring degron network	0.1111
p.S445L	TCGA-AA-A010	COAD	TCGA	PSTPLAT	DEG_SCF_FBW7_1	431:437	Mutation rewiring degron network	0.1111
p.S445L	TCGA-IH-A3EA	SKCM	TCGA	PSTPLAT	DEG_SCF_FBW7_1	431:437	Mutation rewiring degron network	0.1111
p.L14R	TCGA-AD-6889	COAD	TCGA	ARSTT	DEG_SPOP_SBC_1	8:12	Mutation rewiring degron network	0.2778
p.P434L	TCGA-AX-A1CE	UCEC	TCGA	PSTPLAT	DEG_SCF_FBW7_1	431:437	Mutation altering degron motif	0.7582
p.G657S	TCGA-BH-A0C1	BRCA	TCGA	LSPYSD	LIG_APCC_ABBA_1	644:649	Mutation rewiring degron network	0.1111
p.L502F	TCGA-BR-6452	STAD	TCGA	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation altering degron motif	0.587
p.P509H	TCGA-CD-A4MG	STAD	TCGA	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation rewiring degron network	0.1389
p.R7G	TCGA-CR-6472	HNSC	TCGA	ARSTT	DEG_SPOP_SBC_1	8:12	Mutation rewiring degron network	0.3056
p.R7G	DO15870	HNSC	ICGC	ARSTT	DEG_SPOP_SBC_1	8:12	Mutation rewiring degron network	0.3056
p.A2T	TCGA-CS-5395	LGG	TCGA	ARSTT	DEG_SPOP_SBC_1	8:12	Mutation rewiring degron network	0.1667
p.A2T	DO22356	LGG	ICGC	ARSTT	DEG_SPOP_SBC_1	8:12	Mutation rewiring degron network	0.1667
p.P440H	TCGA-D3-A3C7	SKCM	TCGA	PSTPLAT	DEG_SCF_FBW7_1	431:437	Mutation rewiring degron network	0.25
p.S495F	TCGA-DA-A1HV	SKCM	TCGA	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation altering degron motif	0.6871
p.R15H	TCGA-DF-A2KN	UCEC	TCGA	ARSTT	DEG_SPOP_SBC_1	8:12	Mutation rewiring degron network	0.25
p.P646S	TCGA-EE-A2MD	SKCM	TCGA	LSPYSD	LIG_APCC_ABBA_1	644:649	Mutation altering degron motif	0.6752
p.R9M	TCGA-F5-6814	READ	TCGA	ARSTT	DEG_SPOP_SBC_1	8:12	Mutation altering degron motif	0.7521
p.R9M	DO36556	READ	ICGC	ARSTT	DEG_SPOP_SBC_1	8:12	Mutation altering degron motif	0.7521
p.P509L	TCGA-FA-A6HN	DLBC	TCGA	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation rewiring degron network	0.1389
p.A484V	TCGA-FW-A3R5	SKCM	TCGA	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation rewiring degron network	0.1667
p.A484V	SIDM00282	Colorectal Carcinoma	GDSC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation rewiring degron network	0.1667
p.A484V	ACH-000998	Colon/Colorectal Cancer	CCLE	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation rewiring degron network	0.1667
p.A484V	CW-2	large intestine	COSMIC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation rewiring degron network	0.1667
p.P431A	TCGA-GU-A767	BLCA	TCGA	PSTPLAT	DEG_SCF_FBW7_1	431:437	Mutation altering degron motif	0.7503
p.R438W	TCGA-HU-A4GU	STAD	TCGA	PSTPLAT	DEG_SCF_FBW7_1	431:437	Mutation rewiring degron network	0.3056
p.G656R	TCGA-IQ-7630	HNSC	TCGA	LSPYSD	LIG_APCC_ABBA_1	644:649	Mutation rewiring degron network	0.1389
p.Q480H	TCGA-MP-A4TA	LUAD	TCGA	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation rewiring degron network	0.0556
p.W436C	DO222497	BTCA	ICGC	PSTPLAT	DEG_SCF_FBW7_1	431:437	Mutation altering degron motif	0.7
p.A16T	DO51609	CESC	ICGC	ARSTT	DEG_SPOP_SBC_1	8:12	Mutation substituting flanking lysine	0.3333
p.A16T	DO44299	CESC	ICGC	ARSTT	DEG_SPOP_SBC_1	8:12	Mutation substituting flanking lysine	0.3333
p.A16T	DO43755	UCEC	ICGC	ARSTT	DEG_SPOP_SBC_1	8:12	Mutation substituting flanking lysine	0.3333
p.L12R	DO8463	COAD	ICGC	ARSTT	DEG_SPOP_SBC_1	8:12	Mutation altering degron motif	0.8428
p.A426V	DO222790	COCA	ICGC	PSTPLAT	DEG_SCF_FBW7_1	431:437	Mutation rewiring degron network	0.1944
p.R486C	DO233156	GACA	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation rewiring degron network	0.2222
p.R486H	DO233764	GACA	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation rewiring degron network	0.2222
p.R486H	DO38711	STAD	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation rewiring degron network	0.2222
p.D443G	DO11651	GBM	ICGC	PSTPLAT	DEG_SCF_FBW7_1	431:437	Mutation rewiring degron network	0.1667
p.E480V	DO51162	GBM	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation rewiring degron network	0.0556
p.G488W	DO50458	KIRC	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation rewiring degron network	0.2778
p.R9L	DO228952	LICA	ICGC	ARSTT	DEG_SPOP_SBC_1	8:12	Mutation altering degron motif	0.7316
p.M440I	DO229036	LICA	ICGC	PSTPLAT	DEG_SCF_FBW7_1	431:437	Mutation rewiring degron network	0.25
p.M509I	DO229038	LICA	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation rewiring degron network	0.1389
p.S497I	DO229008	LICA	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation altering degron motif	0.7341
p.C12Y	DO50970	LICA	ICGC	ARSTT	DEG_SPOP_SBC_1	8:12	Mutation altering degron motif	0.7087
p.C495F	DO23010	LIHC	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation altering degron motif	0.7108
p.F444S	DO231754	LINC	ICGC	PSTPLAT	DEG_SCF_FBW7_1	431:437	Mutation rewiring degron network	0.1389
p.R2C	DO231868	LINC	ICGC	ARSTT	DEG_SPOP_SBC_1	8:12	Mutation rewiring degron network	0.1667
p.A510S	DO48727	LIRI	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation rewiring degron network	0.1111
p.V434A	DO48682	LIRI	ICGC	PSTPLAT	DEG_SCF_FBW7_1	431:437	Mutation altering degron motif	0.6936
p.D430Y	DO25396	LUAD	ICGC	PSTPLAT	DEG_SCF_FBW7_1	431:437	Mutation rewiring degron network	0.3056
p.C14Y	DO23806	LUAD	ICGC	ARSTT	DEG_SPOP_SBC_1	8:12	Mutation rewiring degron network	0.2778
p.C14Y	DO50267	PAAD	ICGC	ARSTT	DEG_SPOP_SBC_1	8:12	Mutation rewiring degron network	0.2778
p.Q424H	DO45314	LUAD	ICGC	PSTPLAT	DEG_SCF_FBW7_1	431:437	Mutation rewiring degron network	0.1389
p.W487C	DO26092	LUAD	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation rewiring degron network	0.25
p.C495Y	DO26455	LUSC	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation altering degron motif	0.7087
p.P508S	DO220878	MELA	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation rewiring degron network	0.1667
p.P508S	DO37515	SKCM	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation rewiring degron network	0.1667
p.S504L	DO218697	ORCA	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation rewiring degron network	0.2778
p.G488R	DO220239	SARC	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation rewiring degron network	0.2778
p.S439F	DO37659	SKCM	ICGC	PSTPLAT	DEG_SCF_FBW7_1	431:437	Mutation rewiring degron network	0.2778
p.P508L	DO37881	SKCM	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation rewiring degron network	0.1667
p.P508L	DO47555	SKCM	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation rewiring degron network	0.1667
p.P498L	DO37831	SKCM	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation altering degron motif	0.7582
p.P498L	DO37429	SKCM	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation altering degron motif	0.7582
p.A428V	DO37406	SKCM	ICGC	PSTPLAT	DEG_SCF_FBW7_1	431:437	Mutation rewiring degron network	0.25
p.G18E	DO37495	SKCM	ICGC	ARSTT	DEG_SPOP_SBC_1	8:12	Mutation substituting flanking lysine	0.2778
p.S499F	DO51248	SKCM	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation altering degron motif	0.7982
p.S499F	DO38123	SKCM	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation altering degron motif	0.7982
p.P481S	DO219503	SKCM	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation rewiring degron network	0.0833
p.R22S	DO38404	STAD	ICGC	ARSTT	DEG_SPOP_SBC_1	8:12	Mutation rewiring degron network	0.0556
p.L446F	DO38404	STAD	ICGC	PSTPLAT	DEG_SCF_FBW7_1	431:437	Mutation rewiring degron network	0.0833
p.R492P	DO229264	THCA	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation altering degron motif	0.7512
p.Q431K	DO229229	THCA	ICGC	PSTPLAT	DEG_SCF_FBW7_1	431:437	Mutation altering degron motif	0.6944
p.F428L	DO229242	THCA	ICGC	PSTPLAT	DEG_SCF_FBW7_1	431:437	Mutation rewiring degron network	0.25
p.A13T	DO223282	UCEC	ICGC	ARSTT	DEG_SPOP_SBC_1	8:12	Mutation rewiring degron network	0.3056
p.P442L	DO41578	UCEC	ICGC	PSTPLAT	DEG_SCF_FBW7_1	431:437	Mutation rewiring degron network	0.1944
p.A8T	DO41392	UCEC	ICGC	ARSTT	DEG_SPOP_SBC_1	8:12	Mutation altering degron motif	0.7139
p.A504S	SIDM00845	Burkitt's Lymphoma	GDSC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation rewiring degron network	0.2778
p.A504S	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation rewiring degron network	0.2778
p.A511T	SIDM00263	Ewing's Sarcoma	GDSC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation rewiring degron network	0.0833
p.S505I	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation rewiring degron network	0.25
p.S505I	H513	pleura	COSMIC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation rewiring degron network	0.25
p.L643M	SIDM01088	Endometrial Carcinoma	GDSC	LSPYSD	LIG_APCC_ABBA_1	644:649	Mutation rewiring degron network	0.3056
p.L643M	ACH-000965	Endometrial/Uterine Cancer	CCLE	LSPYSD	LIG_APCC_ABBA_1	644:649	Mutation rewiring degron network	0.3056
p.L643M	RL95-2	endometrium	COSMIC	LSPYSD	LIG_APCC_ABBA_1	644:649	Mutation rewiring degron network	0.3056
p.P509R	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation rewiring degron network	0.1389
p.P509R	KYSE-70	oesophagus	COSMIC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation rewiring degron network	0.1389
p.T12M	SIDM00951	T-Lymphoblastic Leukemia	GDSC	ARSTT	DEG_SPOP_SBC_1	8:12	Mutation altering degron motif	0.7423
p.T12M	ACH-002222	Leukemia	CCLE	ARSTT	DEG_SPOP_SBC_1	8:12	Mutation altering degron motif	0.7423
p.T12M	CTV-1	haematopoietic and lymphoid tissue	COSMIC	ARSTT	DEG_SPOP_SBC_1	8:12	Mutation altering degron motif	0.7423
p.S432G	SIDM00850	Gastric Carcinoma	GDSC	PSTPLAT	DEG_SCF_FBW7_1	431:437	Mutation altering degron motif	0.5882
p.S432G	ACH-000880	Gastric Cancer	CCLE	PSTPLAT	DEG_SCF_FBW7_1	431:437	Mutation altering degron motif	0.5882
p.S432G	AGS	stomach	COSMIC	PSTPLAT	DEG_SCF_FBW7_1	431:437	Mutation altering degron motif	0.5882
p.P641A	SIDM01318	Hepatocellular Carcinoma	GDSC	LSPYSD	LIG_APCC_ABBA_1	644:649	Mutation rewiring degron network	0.25
p.P641A	ACH-001318	Liver Cancer	CCLE	LSPYSD	LIG_APCC_ABBA_1	644:649	Mutation rewiring degron network	0.25
p.F659S	ACH-000720	Bladder Cancer	CCLE	LSPYSD	LIG_APCC_ABBA_1	644:649	Mutation rewiring degron network	0.0556
p.F659S	TCCSUP	urinary tract	COSMIC	LSPYSD	LIG_APCC_ABBA_1	644:649	Mutation rewiring degron network	0.0556
p.E511K	IPC-298	skin	COSMIC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation rewiring degron network	0.0833
p.E511K	RPMI-8226	haematopoietic and lymphoid tissue	COSMIC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation rewiring degron network	0.0833
p.S430G	AGS	stomach	COSMIC	PSTPLAT	DEG_SCF_FBW7_1	431:437	Mutation rewiring degron network	0.3056
p.S507N	SNU-81	large intestine	COSMIC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation rewiring degron network	0.1944
p.F657L	ALL-SIL	haematopoietic and lymphoid tissue	COSMIC	LSPYSD	LIG_APCC_ABBA_1	644:649	Mutation rewiring degron network	0.1111
p.P507R	KYSE-70	oesophagus	COSMIC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation rewiring degron network	0.1944
p.L641M	RL95-2	endometrium	COSMIC	LSPYSD	LIG_APCC_ABBA_1	644:649	Mutation rewiring degron network	0.25
p.S436I	H513	pleura	COSMIC	PSTPLAT	DEG_SCF_FBW7_1	431:437	Mutation altering degron motif	0.7341
p.P659R	OAW-28	ovary	COSMIC	LSPYSD	LIG_APCC_ABBA_1	644:649	Mutation rewiring degron network	0.0556
p.T10M	CTV-1	haematopoietic and lymphoid tissue	COSMIC	ARSTT	DEG_SPOP_SBC_1	8:12	Mutation altering degron motif	0.7423
p.P440R	KYSE-70	oesophagus	COSMIC	PSTPLAT	DEG_SCF_FBW7_1	431:437	Mutation rewiring degron network	0.25
p.F659L	ALL-SIL	haematopoietic and lymphoid tissue	COSMIC	LSPYSD	LIG_APCC_ABBA_1	644:649	Mutation rewiring degron network	0.0556
p.S503I	H513	pleura	COSMIC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation rewiring degron network	0.3056
p.A482V	CW-2	large intestine	COSMIC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	490:502	Mutation rewiring degron network	0.1111
p.F657S	TCCSUP	urinary tract	COSMIC	LSPYSD	LIG_APCC_ABBA_1	644:649	Mutation rewiring degron network	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HIF3A

UniProt ID: Q9Y2N7

Entrez ID: 64344

Protein name: Hypoxia-inducible factor 3-alpha (HIF-3-alpha) (HIF3-alpha) (Basic-helix-loop-helix-PAS protein MOP7) (Class E basic helix-loop-helix protein 17) (bHLHe17) (HIF3-alpha-1) (Inhibitory PAS domain protein) (IPAS) (Member of PAS protein 7) (PAS domain-containing protein 7)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HIF3A in