DegronMD

Uniprot ID: Q9Y2N7

Source protein: Hypoxia-inducible factor 3-alpha

Source gene: HIF3A

Class: LIG_APCC_ABBA_1

Location: 644:649

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9444

ASA_SCORE: 70.9

COIL: 0.865

CONS_SCORE: 0.5085

DSS_SCORE: 0.7439

HELIX: 0.0387

FCONS_SCORE: 1.0079

RIG_SCORE: 0.6434

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P641H	TCGA-43-6143	LUSC	TCGA	LSPYSD	LIG_APCC_ABBA_1	0.25
p.G657S	TCGA-BH-A0C1	BRCA	TCGA	LSPYSD	LIG_APCC_ABBA_1	0.1111
p.P646S	TCGA-EE-A2MD	SKCM	TCGA	LSPYSD	LIG_APCC_ABBA_1	0.6752
p.G656R	TCGA-IQ-7630	HNSC	TCGA	LSPYSD	LIG_APCC_ABBA_1	0.1389
p.L643M	SIDM01088	Endometrial Carcinoma	GDSC	LSPYSD	LIG_APCC_ABBA_1	0.3056
p.L643M	ACH-000965	Endometrial/Uterine Cancer	CCLE	LSPYSD	LIG_APCC_ABBA_1	0.3056
p.L643M	RL95-2	endometrium	COSMIC	LSPYSD	LIG_APCC_ABBA_1	0.3056
p.P641A	SIDM01318	Hepatocellular Carcinoma	GDSC	LSPYSD	LIG_APCC_ABBA_1	0.25
p.P641A	ACH-001318	Liver Cancer	CCLE	LSPYSD	LIG_APCC_ABBA_1	0.25
p.F659S	ACH-000720	Bladder Cancer	CCLE	LSPYSD	LIG_APCC_ABBA_1	0.0556
p.F659S	TCCSUP	urinary_tract	COSMIC	LSPYSD	LIG_APCC_ABBA_1	0.0556
p.F657L	ALL-SIL	haematopoietic_and_lymphoid_tissue	COSMIC	LSPYSD	LIG_APCC_ABBA_1	0.1111
p.L641M	RL95-2	endometrium	COSMIC	LSPYSD	LIG_APCC_ABBA_1	0.25
p.P659R	OAW-28	ovary	COSMIC	LSPYSD	LIG_APCC_ABBA_1	0.0556
p.F659L	ALL-SIL	haematopoietic_and_lymphoid_tissue	COSMIC	LSPYSD	LIG_APCC_ABBA_1	0.0556
p.F657S	TCCSUP	urinary_tract	COSMIC	LSPYSD	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2N7	Hypoxia-inducible factor 3-alpha	LIG_APCC_ABBA_1	644:649	LSPYSD	APC,CDC20,FZR1	0.9444	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons