DegronMD

Uniprot ID: Q9Y2N7

Source protein: Hypoxia-inducible factor 3-alpha

Source gene: HIF3A

Class: DEG_ODPH_VHL_1

Location: 490:502

E3 ligase: VHL

DEGRON score: 0.9675

ASA_SCORE: 70.8231

COIL: 0.7698

CONS_SCORE: 0.6391

DSS_SCORE: 0.3068

HELIX: 0.1518

FCONS_SCORE: 1.2016

RIG_SCORE: 0.8062

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D499G	TCGA-19-5959	GBM	TCGA	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.6087
p.Q507K	TCGA-33-AASL	LUSC	TCGA	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.1944
p.D486Y	TCGA-55-7907	LUAD	TCGA	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.2222
p.R510G	TCGA-95-7043	LUAD	TCGA	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.1111
p.L502F	TCGA-BR-6452	STAD	TCGA	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.587
p.P509H	TCGA-CD-A4MG	STAD	TCGA	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.1389
p.S495F	TCGA-DA-A1HV	SKCM	TCGA	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.6871
p.P509L	TCGA-FA-A6HN	DLBC	TCGA	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.1389
p.A484V	TCGA-FW-A3R5	SKCM	TCGA	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.1667
p.A484V	SIDM00282	Colorectal Carcinoma	GDSC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.1667
p.A484V	ACH-000998	Colon/Colorectal Cancer	CCLE	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.1667
p.A484V	CW-2	large_intestine	COSMIC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.1667
p.Q480H	TCGA-MP-A4TA	LUAD	TCGA	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.0556
p.R486C	DO233156	GACA	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.2222
p.R486H	DO233764	GACA	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.2222
p.R486H	DO38711	STAD	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.2222
p.E480V	DO51162	GBM	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.0556
p.G488W	DO50458	KIRC	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.2778
p.M509I	DO229038	LICA	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.1389
p.S497I	DO229008	LICA	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.7341
p.C495F	DO23010	LIHC	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.7108
p.A510S	DO48727	LIRI	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.1111
p.W487C	DO26092	LUAD	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.25
p.C495Y	DO26455	LUSC	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.7087
p.P508S	DO220878	MELA	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.1667
p.P508S	DO37515	SKCM	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.1667
p.S504L	DO218697	ORCA	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.2778
p.G488R	DO220239	SARC	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.2778
p.P508L	DO37881	SKCM	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.1667
p.P508L	DO47555	SKCM	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.1667
p.P498L	DO37831	SKCM	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.7582
p.P498L	DO37429	SKCM	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.7582
p.S499F	DO51248	SKCM	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.7982
p.S499F	DO38123	SKCM	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.7982
p.P481S	DO219503	SKCM	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.0833
p.R492P	DO229264	THCA	ICGC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.7512
p.A504S	SIDM00845	Burkitt's Lymphoma	GDSC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.2778
p.A504S	SIDM00946	T-Lymphoblastic Leukemia	GDSC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.2778
p.A511T	SIDM00263	Ewing's Sarcoma	GDSC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.0833
p.S505I	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.25
p.S505I	H513	pleura	COSMIC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.25
p.P509R	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.1389
p.P509R	KYSE-70	oesophagus	COSMIC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.1389
p.E511K	IPC-298	skin	COSMIC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.0833
p.E511K	RPMI-8226	haematopoietic_and_lymphoid_tissue	COSMIC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.0833
p.S507N	SNU-81	large_intestine	COSMIC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.1944
p.P507R	KYSE-70	oesophagus	COSMIC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.1944
p.S503I	H513	pleura	COSMIC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.3056
p.A482V	CW-2	large_intestine	COSMIC	LAPYISMDDDFQL	DEG_ODPH_VHL_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LAPYISMDDDFQL

Degron related mutations and impact score

Drug responses associated with HIF3A mutations

All proteins holding degron of LAPYISMDDDFQL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2N7	Hypoxia-inducible factor 3-alpha	DEG_ODPH_VHL_1	490:502	LAPYISMDDDFQL	VHL	0.9675	More...