DegronMD

Uniprot ID: Q9Y2N7

Source protein: Hypoxia-inducible factor 3-alpha

Source gene: HIF3A

Class: DEG_SPOP_SBC_1

Location: 8:12

E3 ligase: SPOP

DEGRON score: 0.7168

ASA_SCORE: 102.16

COIL: 0.883

CONS_SCORE: 0.4929

DSS_SCORE: 0.6476

HELIX: 0.111

FCONS_SCORE: 0.7619

RIG_SCORE: 0.7142

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E17K	TCGA-5L-AAT1	BRCA	TCGA	ARSTT	DEG_SPOP_SBC_1	0.1944
p.E17K	DO219594	BRCA	ICGC	ARSTT	DEG_SPOP_SBC_1	0.1944
p.L14R	TCGA-AD-6889	COAD	TCGA	ARSTT	DEG_SPOP_SBC_1	0.2778
p.R7G	TCGA-CR-6472	HNSC	TCGA	ARSTT	DEG_SPOP_SBC_1	0.3056
p.R7G	DO15870	HNSC	ICGC	ARSTT	DEG_SPOP_SBC_1	0.3056
p.A2T	TCGA-CS-5395	LGG	TCGA	ARSTT	DEG_SPOP_SBC_1	0.1667
p.A2T	DO22356	LGG	ICGC	ARSTT	DEG_SPOP_SBC_1	0.1667
p.R15H	TCGA-DF-A2KN	UCEC	TCGA	ARSTT	DEG_SPOP_SBC_1	0.25
p.R9M	TCGA-F5-6814	READ	TCGA	ARSTT	DEG_SPOP_SBC_1	0.7521
p.R9M	DO36556	READ	ICGC	ARSTT	DEG_SPOP_SBC_1	0.7521
p.A16T	DO51609	CESC	ICGC	ARSTT	DEG_SPOP_SBC_1	0.3333
p.A16T	DO44299	CESC	ICGC	ARSTT	DEG_SPOP_SBC_1	0.3333
p.A16T	DO43755	UCEC	ICGC	ARSTT	DEG_SPOP_SBC_1	0.3333
p.L12R	DO8463	COAD	ICGC	ARSTT	DEG_SPOP_SBC_1	0.8428
p.R9L	DO228952	LICA	ICGC	ARSTT	DEG_SPOP_SBC_1	0.7316
p.C12Y	DO50970	LICA	ICGC	ARSTT	DEG_SPOP_SBC_1	0.7087
p.R2C	DO231868	LINC	ICGC	ARSTT	DEG_SPOP_SBC_1	0.1667
p.C14Y	DO23806	LUAD	ICGC	ARSTT	DEG_SPOP_SBC_1	0.2778
p.C14Y	DO50267	PAAD	ICGC	ARSTT	DEG_SPOP_SBC_1	0.2778
p.G18E	DO37495	SKCM	ICGC	ARSTT	DEG_SPOP_SBC_1	0.2778
p.R22S	DO38404	STAD	ICGC	ARSTT	DEG_SPOP_SBC_1	0.0556
p.A13T	DO223282	UCEC	ICGC	ARSTT	DEG_SPOP_SBC_1	0.3056
p.A8T	DO41392	UCEC	ICGC	ARSTT	DEG_SPOP_SBC_1	0.7139
p.T12M	SIDM00951	T-Lymphoblastic Leukemia	GDSC	ARSTT	DEG_SPOP_SBC_1	0.7423
p.T12M	ACH-002222	Leukemia	CCLE	ARSTT	DEG_SPOP_SBC_1	0.7423
p.T12M	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	ARSTT	DEG_SPOP_SBC_1	0.7423
p.T10M	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	ARSTT	DEG_SPOP_SBC_1	0.7423

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94964	Protein SOGA1	DEG_SPOP_SBC_1	1236:1240	ARSTT	SPOP	0.9985	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	818:822	ARSTT	SPOP	0.6179	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	927:931	ARSTT	SPOP	0.959	More...
Q9Y2N7	Hypoxia-inducible factor 3-alpha	DEG_SPOP_SBC_1	8:12	ARSTT	SPOP	0.7168	More...
A6NDY2	Putative protein FAM90A10	DEG_SPOP_SBC_1	54:58	ARSTT	SPOP	0.5218	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons