DegronMD

Uniprot ID: Q9UKN1

Source protein: Mucin-12

Source gene: MUC12

Class: DEG_SPOP_SBC_1

Location: 927:931

E3 ligase: SPOP

DEGRON score: 0.959

ASA_SCORE: 100.24

COIL: 0.8096

CONS_SCORE: 0

DSS_SCORE: 0.5493

HELIX: 0.0232

FCONS_SCORE: 0

RIG_SCORE: 0.7502

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R928H	DO222884	COCA	ICGC	ARSTT	DEG_SPOP_SBC_1	0.7133
p.R928H	DO229032	LICA	ICGC	ARSTT	DEG_SPOP_SBC_1	0.7133
p.R928H	DO232761	PBCA	ICGC	ARSTT	DEG_SPOP_SBC_1	0.7133
p.T931N	DO229016	COCA	ICGC	ARSTT	DEG_SPOP_SBC_1	0.7055
p.T920M	DO234389	ESAD	ICGC	ARSTT	DEG_SPOP_SBC_1	0.1389
p.T920M	SJSA-1	bone	COSMIC	ARSTT	DEG_SPOP_SBC_1	0.1389
p.R928C	DO52674	MALY	ICGC	ARSTT	DEG_SPOP_SBC_1	0.719
p.S929F	DO222653	MELA	ICGC	ARSTT	DEG_SPOP_SBC_1	0.9093
p.L934F	DO222875	MELA	ICGC	ARSTT	DEG_SPOP_SBC_1	0.25
p.A919T	DO232761	PBCA	ICGC	ARSTT	DEG_SPOP_SBC_1	0.1111
p.A919T	LN-18	central_nervous_system	COSMIC	ARSTT	DEG_SPOP_SBC_1	0.1111
p.A919T	IGR-1	skin	COSMIC	ARSTT	DEG_SPOP_SBC_1	0.1111
p.A919T	H2595	pleura	COSMIC	ARSTT	DEG_SPOP_SBC_1	0.1111
p.A919T	H2869	pleura	COSMIC	ARSTT	DEG_SPOP_SBC_1	0.1111
p.G924S	SIDM00214	Colorectal Carcinoma	GDSC	ARSTT	DEG_SPOP_SBC_1	0.25
p.G924S	SNU-407	large_intestine	COSMIC	ARSTT	DEG_SPOP_SBC_1	0.25
p.T939M	ACH-001977	Primary	CCLE	ARSTT	DEG_SPOP_SBC_1	0.1111
p.V924L	SW780	urinary_tract	COSMIC	ARSTT	DEG_SPOP_SBC_1	0.25
p.P926T	NCI-H1299	lung	COSMIC	ARSTT	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94964	Protein SOGA1	DEG_SPOP_SBC_1	1236:1240	ARSTT	SPOP	0.9985	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	818:822	ARSTT	SPOP	0.6179	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	927:931	ARSTT	SPOP	0.959	More...
Q9Y2N7	Hypoxia-inducible factor 3-alpha	DEG_SPOP_SBC_1	8:12	ARSTT	SPOP	0.7168	More...
A6NDY2	Putative protein FAM90A10	DEG_SPOP_SBC_1	54:58	ARSTT	SPOP	0.5218	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons