DegronMD

Uniprot ID: Q9UKN1

Source protein: Mucin-12

Source gene: MUC12

Class: DEG_SPOP_SBC_1

Location: 818:822

E3 ligase: SPOP

DEGRON score: 0.6179

ASA_SCORE: 93.52

COIL: 0.7676

CONS_SCORE: 0

DSS_SCORE: 0.6544

HELIX: 0.0296

FCONS_SCORE: 0

RIG_SCORE: 0.6508

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S820F	DO233764	GACA	ICGC	ARSTT	DEG_SPOP_SBC_1	0.7982
p.S817C	DO228634	LICA	ICGC	ARSTT	DEG_SPOP_SBC_1	0.3056
p.I816F	DO228943	LICA	ICGC	ARSTT	DEG_SPOP_SBC_1	0.2778
p.I816F	DO229053	LICA	ICGC	ARSTT	DEG_SPOP_SBC_1	0.2778
p.I811T	DO229063	LICA	ICGC	ARSTT	DEG_SPOP_SBC_1	0.1389
p.P812Q	DO50889	LICA	ICGC	ARSTT	DEG_SPOP_SBC_1	0.1667
p.H815N	DO230929	LUSC	ICGC	ARSTT	DEG_SPOP_SBC_1	0.25
p.H815N	DO224572	LUSC	ICGC	ARSTT	DEG_SPOP_SBC_1	0.25
p.P808S	DO231043	LUSC	ICGC	ARSTT	DEG_SPOP_SBC_1	0.0556
p.T821P	DO222702	MELA	ICGC	ARSTT	DEG_SPOP_SBC_1	0.8142
p.S809R	DO42400	UCEC	ICGC	ARSTT	DEG_SPOP_SBC_1	0.5278
p.G812S	SIDM01269	Esophageal Carcinoma	GDSC	ARSTT	DEG_SPOP_SBC_1	0.1667
p.S823C	SIDM00303	Ovarian Carcinoma	GDSC	ARSTT	DEG_SPOP_SBC_1	0.3056
p.S823C	JHOS-4	ovary	COSMIC	ARSTT	DEG_SPOP_SBC_1	0.3056
p.P808A	CCF-STTG1	central_nervous_system	COSMIC	ARSTT	DEG_SPOP_SBC_1	0.0556
p.P808Q	NCI-H2342	lung	COSMIC	ARSTT	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94964	Protein SOGA1	DEG_SPOP_SBC_1	1236:1240	ARSTT	SPOP	0.9985	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	818:822	ARSTT	SPOP	0.6179	More...
Q9UKN1	Mucin-12	DEG_SPOP_SBC_1	927:931	ARSTT	SPOP	0.959	More...
Q9Y2N7	Hypoxia-inducible factor 3-alpha	DEG_SPOP_SBC_1	8:12	ARSTT	SPOP	0.7168	More...
A6NDY2	Putative protein FAM90A10	DEG_SPOP_SBC_1	54:58	ARSTT	SPOP	0.5218	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons