DegronMD

Uniprot ID: Q9Y2N7

Source protein: Hypoxia-inducible factor 3-alpha

Source gene: HIF3A

Class: DEG_SCF_FBW7_1

Location: 431:437

E3 ligase: FBXW7

DEGRON score: 0.9943

ASA_SCORE: 81.7857

COIL: 0.9257

CONS_SCORE: 0.537

DSS_SCORE: 0.6037

HELIX: 0.0506

FCONS_SCORE: 1.0533

RIG_SCORE: 0.6389

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S445L	TCGA-AA-A010	COAD	TCGA	PSTPLAT	DEG_SCF_FBW7_1	0.1111
p.S445L	TCGA-IH-A3EA	SKCM	TCGA	PSTPLAT	DEG_SCF_FBW7_1	0.1111
p.P434L	TCGA-AX-A1CE	UCEC	TCGA	PSTPLAT	DEG_SCF_FBW7_1	0.7582
p.P440H	TCGA-D3-A3C7	SKCM	TCGA	PSTPLAT	DEG_SCF_FBW7_1	0.25
p.P431A	TCGA-GU-A767	BLCA	TCGA	PSTPLAT	DEG_SCF_FBW7_1	0.7503
p.R438W	TCGA-HU-A4GU	STAD	TCGA	PSTPLAT	DEG_SCF_FBW7_1	0.3056
p.W436C	DO222497	BTCA	ICGC	PSTPLAT	DEG_SCF_FBW7_1	0.7
p.A426V	DO222790	COCA	ICGC	PSTPLAT	DEG_SCF_FBW7_1	0.1944
p.D443G	DO11651	GBM	ICGC	PSTPLAT	DEG_SCF_FBW7_1	0.1667
p.M440I	DO229036	LICA	ICGC	PSTPLAT	DEG_SCF_FBW7_1	0.25
p.F444S	DO231754	LINC	ICGC	PSTPLAT	DEG_SCF_FBW7_1	0.1389
p.V434A	DO48682	LIRI	ICGC	PSTPLAT	DEG_SCF_FBW7_1	0.6936
p.D430Y	DO25396	LUAD	ICGC	PSTPLAT	DEG_SCF_FBW7_1	0.3056
p.Q424H	DO45314	LUAD	ICGC	PSTPLAT	DEG_SCF_FBW7_1	0.1389
p.S439F	DO37659	SKCM	ICGC	PSTPLAT	DEG_SCF_FBW7_1	0.2778
p.A428V	DO37406	SKCM	ICGC	PSTPLAT	DEG_SCF_FBW7_1	0.25
p.L446F	DO38404	STAD	ICGC	PSTPLAT	DEG_SCF_FBW7_1	0.0833
p.Q431K	DO229229	THCA	ICGC	PSTPLAT	DEG_SCF_FBW7_1	0.6944
p.F428L	DO229242	THCA	ICGC	PSTPLAT	DEG_SCF_FBW7_1	0.25
p.P442L	DO41578	UCEC	ICGC	PSTPLAT	DEG_SCF_FBW7_1	0.1944
p.S432G	SIDM00850	Gastric Carcinoma	GDSC	PSTPLAT	DEG_SCF_FBW7_1	0.5882
p.S432G	ACH-000880	Gastric Cancer	CCLE	PSTPLAT	DEG_SCF_FBW7_1	0.5882
p.S432G	AGS	stomach	COSMIC	PSTPLAT	DEG_SCF_FBW7_1	0.5882
p.S430G	AGS	stomach	COSMIC	PSTPLAT	DEG_SCF_FBW7_1	0.3056
p.S436I	H513	pleura	COSMIC	PSTPLAT	DEG_SCF_FBW7_1	0.7341
p.P440R	KYSE-70	oesophagus	COSMIC	PSTPLAT	DEG_SCF_FBW7_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9Y2N7	Hypoxia-inducible factor 3-alpha	DEG_SCF_FBW7_1	431:437	PSTPLAT	FBXW7	0.9943	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons