DegronMD

Uniprot ID: O94964

Source protein: Protein SOGA1

Source gene: SOGA1

Class: DEG_SPOP_SBC_1

Location: 1127:1131

E3 ligase: SPOP

DEGRON score: 0.9469

ASA_SCORE: 90.1

COIL: 0.8584

CONS_SCORE: 0.4884

DSS_SCORE: 0.487

HELIX: 0.0966

FCONS_SCORE: 0.8151

RIG_SCORE: 0.7089

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1139C	TCGA-AA-A022	COAD	TCGA	VKSTS	DEG_SPOP_SBC_1	0.5556
p.R1139C	DO10647	COAD	ICGC	VKSTS	DEG_SPOP_SBC_1	0.5556
p.A1118S	DO233874	GACA	ICGC	VKSTS	DEG_SPOP_SBC_1	0.0833
p.A1118V	SIDM00251	Gastric Carcinoma	GDSC	VKSTS	DEG_SPOP_SBC_1	0.0833
p.A1118V	TGBC11TKB	stomach	COSMIC	VKSTS	DEG_SPOP_SBC_1	0.0833
p.R1119C	ACH-000930	Breast Cancer	CCLE	VKSTS	DEG_SPOP_SBC_1	0.1111
p.T1134M	ACH-000943	Colon/Colorectal Cancer	CCLE	VKSTS	DEG_SPOP_SBC_1	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94964	Protein SOGA1	DEG_SPOP_SBC_1	1127:1131	VKSTS	SPOP	0.9469	More...
Q7Z6E9	E3 ubiquitin-protein ligase RBBP6	DEG_SPOP_SBC_1	80:84	VKSTS	SPOP	0.9745	More...
Q9Y462	Zinc finger protein 711	DEG_SPOP_SBC_1	196:200	VKSTS	SPOP	0.9584	More...
Q8N5R6	Coiled-coil domain-containing protein 33	DEG_SPOP_SBC_1	265:269	VKSTS	SPOP	0.7639	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons