DegronMD

Uniprot ID: Q9Y462

Source protein: Zinc finger protein 711

Source gene: ZNF711

Class: DEG_SPOP_SBC_1

Location: 196:200

E3 ligase: SPOP

DEGRON score: 0.9584

ASA_SCORE: 82.5

COIL: 0.737

CONS_SCORE: 0.8516

DSS_SCORE: 0.5437

HELIX: 0.1566

FCONS_SCORE: 1.04

RIG_SCORE: 0.758

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K197N	TCGA-AP-A0LM	UCEC	TCGA	VKSTS	DEG_SPOP_SBC_1	0.5806
p.K197N	DO43306	UCEC	ICGC	VKSTS	DEG_SPOP_SBC_1	0.5806
p.T188A	TCGA-BR-4362	STAD	TCGA	VKSTS	DEG_SPOP_SBC_1	0.1111
p.T188A	DO38336	STAD	ICGC	VKSTS	DEG_SPOP_SBC_1	0.1111
p.D190E	TCGA-BR-8078	STAD	TCGA	VKSTS	DEG_SPOP_SBC_1	0.1667
p.D190E	DO38288	STAD	ICGC	VKSTS	DEG_SPOP_SBC_1	0.1667
p.D191N	TCGA-UY-A78O	BLCA	TCGA	VKSTS	DEG_SPOP_SBC_1	0.1944
p.D191N	DO219035	BLCA	ICGC	VKSTS	DEG_SPOP_SBC_1	0.1944
p.I186T	TCGA-XF-AAMQ	BLCA	TCGA	VKSTS	DEG_SPOP_SBC_1	0.0556
p.I186T	DO51934	BLCA	ICGC	VKSTS	DEG_SPOP_SBC_1	0.0556
p.D194V	DO50820	LIRI	ICGC	VKSTS	DEG_SPOP_SBC_1	0.2778
p.K197R	DO228603	PRAD	ICGC	VKSTS	DEG_SPOP_SBC_1	0.6126
p.I206M	SIDM00632	Non-Cancerous	GDSC	VKSTS	DEG_SPOP_SBC_1	0.1667
p.I206M	ACH-002247	Non-Cancerous	CCLE	VKSTS	DEG_SPOP_SBC_1	0.1667
p.I206M	IM-9	haematopoietic_and_lymphoid_tissue	COSMIC	VKSTS	DEG_SPOP_SBC_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94964	Protein SOGA1	DEG_SPOP_SBC_1	1127:1131	VKSTS	SPOP	0.9469	More...
Q7Z6E9	E3 ubiquitin-protein ligase RBBP6	DEG_SPOP_SBC_1	80:84	VKSTS	SPOP	0.9745	More...
Q9Y462	Zinc finger protein 711	DEG_SPOP_SBC_1	196:200	VKSTS	SPOP	0.9584	More...
Q8N5R6	Coiled-coil domain-containing protein 33	DEG_SPOP_SBC_1	265:269	VKSTS	SPOP	0.7639	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons