DegronMD - Q8N5R6(CCDC33)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q585H	TCGA-17-Z045	LUAD	TCGA	LTPNNS	DEG_SCF_FBW7_1	574:579	Mutation rewiring degron network	0.1667
p.R583S	TCGA-77-7463	LUSC	TCGA	LTPNNS	DEG_SCF_FBW7_1	574:579	Mutation rewiring degron network	0.2222
p.R583S	DO26716	LUSC	ICGC	LTPNNS	DEG_SCF_FBW7_1	574:579	Mutation rewiring degron network	0.2222
p.R275Q	TCGA-97-A4M5	LUAD	TCGA	VKSTS	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.1667
p.E262D	TCGA-AP-A0LM	UCEC	TCGA	VKSTS	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.25
p.E262D	DO229006	LICA	ICGC	VKSTS	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.25
p.E262D	DO43306	UCEC	ICGC	VKSTS	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.25
p.P261T	TCGA-AP-A1DK	UCEC	TCGA	VKSTS	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.2222
p.P261T	DO42033	UCEC	ICGC	VKSTS	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.2222
p.F272S	TCGA-BR-6458	STAD	TCGA	VKSTS	DEG_SPOP_SBC_1	265:269	Mutation substituting flanking lysine	0.3611
p.F272S	DO38296	STAD	ICGC	VKSTS	DEG_SPOP_SBC_1	265:269	Mutation substituting flanking lysine	0.3611
p.M564I	TCGA-EE-A29D	SKCM	TCGA	LTPNNS	DEG_SCF_FBW7_1	574:579	Mutation rewiring degron network	0.0556
p.M564I	DO38123	SKCM	ICGC	LTPNNS	DEG_SCF_FBW7_1	574:579	Mutation rewiring degron network	0.0556
p.D276Y	TCGA-FI-A2D5	UCEC	TCGA	VKSTS	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.1389
p.G258V	TCGA-FS-A1ZN	SKCM	TCGA	VKSTS	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.1389
p.G258V	DO38165	SKCM	ICGC	VKSTS	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.1389
p.R566Q	TCGA-FW-A3R5	SKCM	TCGA	LTPNNS	DEG_SCF_FBW7_1	574:579	Mutation rewiring degron network	0.1111
p.R566Q	DO37406	SKCM	ICGC	LTPNNS	DEG_SCF_FBW7_1	574:579	Mutation rewiring degron network	0.1111
p.R275P	TCGA-H7-A6C4	HNSC	TCGA	VKSTS	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.1667
p.R571G	DO8264	COAD	ICGC	LTPNNS	DEG_SCF_FBW7_1	574:579	Mutation rewiring degron network	0.25
p.K588N	DO8264	COAD	ICGC	LTPNNS	DEG_SCF_FBW7_1	574:579	Mutation substituting flanking lysine	0.1944
p.K588N	DO41572	UCEC	ICGC	LTPNNS	DEG_SCF_FBW7_1	574:579	Mutation substituting flanking lysine	0.1944
p.R566W	DO222769	COCA	ICGC	LTPNNS	DEG_SCF_FBW7_1	574:579	Mutation rewiring degron network	0.1111
p.R566W	SIDM00217	Colorectal Carcinoma	GDSC	LTPNNS	DEG_SCF_FBW7_1	574:579	Mutation rewiring degron network	0.1111
p.R566W	ACH-000999	Colon/Colorectal Cancer	CCLE	LTPNNS	DEG_SCF_FBW7_1	574:579	Mutation rewiring degron network	0.1111
p.R566W	SNU-1040	large intestine	COSMIC	LTPNNS	DEG_SCF_FBW7_1	574:579	Mutation rewiring degron network	0.1111
p.S276I	DO229026	LICA	ICGC	VKSTS	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.1389
p.H263N	DO26806	LUSC	ICGC	VKSTS	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.2778
p.W260R	DO26516	LUSC	ICGC	VKSTS	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.1944
p.P259S	DO27053	LUSC	ICGC	VKSTS	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.1667
p.A272T	DO228253	MALY	ICGC	VKSTS	DEG_SPOP_SBC_1	265:269	Mutation substituting flanking lysine	0.3611
p.A581T	DO220851	MELA	ICGC	LTPNNS	DEG_SCF_FBW7_1	574:579	Mutation rewiring degron network	0.2778
p.D255N	DO222837	MELA	ICGC	VKSTS	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.0556
p.E568Q	DO232861	NACA	ICGC	LTPNNS	DEG_SCF_FBW7_1	574:579	Mutation rewiring degron network	0.1667
p.P583S	DO220073	SARC	ICGC	LTPNNS	DEG_SCF_FBW7_1	574:579	Mutation rewiring degron network	0.2222
p.P583S	DO37430	SKCM	ICGC	LTPNNS	DEG_SCF_FBW7_1	574:579	Mutation rewiring degron network	0.2222
p.K272M	DO48665	SKCM	ICGC	VKSTS	DEG_SPOP_SBC_1	265:269	Mutation substituting flanking lysine	0.3611
p.E257K	DO48665	SKCM	ICGC	VKSTS	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.1111
p.Q573L	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	LTPNNS	DEG_SCF_FBW7_1	574:579	Mutation rewiring degron network	0.3056
p.Q573L	ACH-000878	Lung Cancer	CCLE	LTPNNS	DEG_SCF_FBW7_1	574:579	Mutation rewiring degron network	0.3056
p.Q573L	HCC-15	lung	COSMIC	LTPNNS	DEG_SCF_FBW7_1	574:579	Mutation rewiring degron network	0.3056
p.V567M	SIDM00999	Bladder Carcinoma	GDSC	LTPNNS	DEG_SCF_FBW7_1	574:579	Mutation rewiring degron network	0.1389
p.V567M	ACH-000973	Bladder Cancer	CCLE	LTPNNS	DEG_SCF_FBW7_1	574:579	Mutation rewiring degron network	0.1389
p.V567M	639-V	urinary tract	COSMIC	LTPNNS	DEG_SCF_FBW7_1	574:579	Mutation rewiring degron network	0.1389
p.D274N	PF-382	haematopoietic and lymphoid tissue	COSMIC	VKSTS	DEG_SPOP_SBC_1	265:269	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CCDC33

UniProt ID: Q8N5R6

Entrez ID: 80125

Protein name: Coiled-coil domain-containing protein 33 (Cancer/testis antigen 61) (CT61)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CCDC33 in