DegronMD

Uniprot ID: Q8N5R6

Source protein: Coiled-coil domain-containing protein 33

Source gene: CCDC33

Class: DEG_SCF_FBW7_1

Location: 574:579

E3 ligase: FBXW7

DEGRON score: 0.8312

ASA_SCORE: 75.0833

COIL: 0.8025

CONS_SCORE: 0.3914

DSS_SCORE: 0.5289

HELIX: 0.1588

FCONS_SCORE: 0.872

RIG_SCORE: 0.6919

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q585H	TCGA-17-Z045	LUAD	TCGA	LTPNNS	DEG_SCF_FBW7_1	0.1667
p.R583S	TCGA-77-7463	LUSC	TCGA	LTPNNS	DEG_SCF_FBW7_1	0.2222
p.R583S	DO26716	LUSC	ICGC	LTPNNS	DEG_SCF_FBW7_1	0.2222
p.M564I	TCGA-EE-A29D	SKCM	TCGA	LTPNNS	DEG_SCF_FBW7_1	0.0556
p.M564I	DO38123	SKCM	ICGC	LTPNNS	DEG_SCF_FBW7_1	0.0556
p.R566Q	TCGA-FW-A3R5	SKCM	TCGA	LTPNNS	DEG_SCF_FBW7_1	0.1111
p.R566Q	DO37406	SKCM	ICGC	LTPNNS	DEG_SCF_FBW7_1	0.1111
p.R571G	DO8264	COAD	ICGC	LTPNNS	DEG_SCF_FBW7_1	0.25
p.K588N	DO8264	COAD	ICGC	LTPNNS	DEG_SCF_FBW7_1	0.1944
p.K588N	DO41572	UCEC	ICGC	LTPNNS	DEG_SCF_FBW7_1	0.1944
p.R566W	DO222769	COCA	ICGC	LTPNNS	DEG_SCF_FBW7_1	0.1111
p.R566W	SIDM00217	Colorectal Carcinoma	GDSC	LTPNNS	DEG_SCF_FBW7_1	0.1111
p.R566W	ACH-000999	Colon/Colorectal Cancer	CCLE	LTPNNS	DEG_SCF_FBW7_1	0.1111
p.R566W	SNU-1040	large_intestine	COSMIC	LTPNNS	DEG_SCF_FBW7_1	0.1111
p.A581T	DO220851	MELA	ICGC	LTPNNS	DEG_SCF_FBW7_1	0.2778
p.E568Q	DO232861	NACA	ICGC	LTPNNS	DEG_SCF_FBW7_1	0.1667
p.P583S	DO220073	SARC	ICGC	LTPNNS	DEG_SCF_FBW7_1	0.2222
p.P583S	DO37430	SKCM	ICGC	LTPNNS	DEG_SCF_FBW7_1	0.2222
p.Q573L	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	LTPNNS	DEG_SCF_FBW7_1	0.3056
p.Q573L	ACH-000878	Lung Cancer	CCLE	LTPNNS	DEG_SCF_FBW7_1	0.3056
p.Q573L	HCC-15	lung	COSMIC	LTPNNS	DEG_SCF_FBW7_1	0.3056
p.V567M	SIDM00999	Bladder Carcinoma	GDSC	LTPNNS	DEG_SCF_FBW7_1	0.1389
p.V567M	ACH-000973	Bladder Cancer	CCLE	LTPNNS	DEG_SCF_FBW7_1	0.1389
p.V567M	639-V	urinary_tract	COSMIC	LTPNNS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8N5R6	Coiled-coil domain-containing protein 33	DEG_SCF_FBW7_1	574:579	LTPNNS	FBXW7	0.8312	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons