DegronMD

Uniprot ID: Q8N5R6

Source protein: Coiled-coil domain-containing protein 33

Source gene: CCDC33

Class: DEG_SPOP_SBC_1

Location: 265:269

E3 ligase: SPOP

DEGRON score: 0.7639

ASA_SCORE: 59.9

COIL: 0.5316

CONS_SCORE: 0.4415

DSS_SCORE: 0.505

HELIX: 0.0256

FCONS_SCORE: 1.0402

RIG_SCORE: 0.7656

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R275Q	TCGA-97-A4M5	LUAD	TCGA	VKSTS	DEG_SPOP_SBC_1	0.1667
p.E262D	TCGA-AP-A0LM	UCEC	TCGA	VKSTS	DEG_SPOP_SBC_1	0.25
p.E262D	DO229006	LICA	ICGC	VKSTS	DEG_SPOP_SBC_1	0.25
p.E262D	DO43306	UCEC	ICGC	VKSTS	DEG_SPOP_SBC_1	0.25
p.P261T	TCGA-AP-A1DK	UCEC	TCGA	VKSTS	DEG_SPOP_SBC_1	0.2222
p.P261T	DO42033	UCEC	ICGC	VKSTS	DEG_SPOP_SBC_1	0.2222
p.F272S	TCGA-BR-6458	STAD	TCGA	VKSTS	DEG_SPOP_SBC_1	0.3611
p.F272S	DO38296	STAD	ICGC	VKSTS	DEG_SPOP_SBC_1	0.3611
p.D276Y	TCGA-FI-A2D5	UCEC	TCGA	VKSTS	DEG_SPOP_SBC_1	0.1389
p.G258V	TCGA-FS-A1ZN	SKCM	TCGA	VKSTS	DEG_SPOP_SBC_1	0.1389
p.G258V	DO38165	SKCM	ICGC	VKSTS	DEG_SPOP_SBC_1	0.1389
p.R275P	TCGA-H7-A6C4	HNSC	TCGA	VKSTS	DEG_SPOP_SBC_1	0.1667
p.S276I	DO229026	LICA	ICGC	VKSTS	DEG_SPOP_SBC_1	0.1389
p.H263N	DO26806	LUSC	ICGC	VKSTS	DEG_SPOP_SBC_1	0.2778
p.W260R	DO26516	LUSC	ICGC	VKSTS	DEG_SPOP_SBC_1	0.1944
p.P259S	DO27053	LUSC	ICGC	VKSTS	DEG_SPOP_SBC_1	0.1667
p.A272T	DO228253	MALY	ICGC	VKSTS	DEG_SPOP_SBC_1	0.3611
p.D255N	DO222837	MELA	ICGC	VKSTS	DEG_SPOP_SBC_1	0.0556
p.K272M	DO48665	SKCM	ICGC	VKSTS	DEG_SPOP_SBC_1	0.3611
p.E257K	DO48665	SKCM	ICGC	VKSTS	DEG_SPOP_SBC_1	0.1111
p.D274N	PF-382	haematopoietic_and_lymphoid_tissue	COSMIC	VKSTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94964	Protein SOGA1	DEG_SPOP_SBC_1	1127:1131	VKSTS	SPOP	0.9469	More...
Q7Z6E9	E3 ubiquitin-protein ligase RBBP6	DEG_SPOP_SBC_1	80:84	VKSTS	SPOP	0.9745	More...
Q9Y462	Zinc finger protein 711	DEG_SPOP_SBC_1	196:200	VKSTS	SPOP	0.9584	More...
Q8N5R6	Coiled-coil domain-containing protein 33	DEG_SPOP_SBC_1	265:269	VKSTS	SPOP	0.7639	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons