DegronMD

Uniprot ID: Q7Z6E9

Source protein: E3 ubiquitin-protein ligase RBBP6

Source gene: RBBP6

Class: DEG_SPOP_SBC_1

Location: 80:84

E3 ligase: SPOP

DEGRON score: 0.9745

ASA_SCORE: 93.98

COIL: 0.8552

CONS_SCORE: 0.3589

DSS_SCORE: 0.2811

HELIX: 0.0294

FCONS_SCORE: 0.7476

RIG_SCORE: 0.7292

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R91Q	TCGA-A5-A2K5	UCEC	TCGA	VKSTS	DEG_SPOP_SBC_1	0.1389
p.R91Q	DO41379	UCEC	ICGC	VKSTS	DEG_SPOP_SBC_1	0.1389
p.R91Q	SIDM01588	Endometrial Carcinoma	GDSC	VKSTS	DEG_SPOP_SBC_1	0.1389
p.R91Q	ACH-000993	Endometrial/Uterine Cancer	CCLE	VKSTS	DEG_SPOP_SBC_1	0.1389
p.T86S	DO52694	MALY	ICGC	VKSTS	DEG_SPOP_SBC_1	0.7222
p.I71V	SIDM01954	Colorectal Carcinoma	GDSC	VKSTS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94964	Protein SOGA1	DEG_SPOP_SBC_1	1127:1131	VKSTS	SPOP	0.9469	More...
Q7Z6E9	E3 ubiquitin-protein ligase RBBP6	DEG_SPOP_SBC_1	80:84	VKSTS	SPOP	0.9745	More...
Q9Y462	Zinc finger protein 711	DEG_SPOP_SBC_1	196:200	VKSTS	SPOP	0.9584	More...
Q8N5R6	Coiled-coil domain-containing protein 33	DEG_SPOP_SBC_1	265:269	VKSTS	SPOP	0.7639	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons