DegronMD - Q5SQI0(ATAT1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S353C	TCGA-2F-A9KO	BLCA	TCGA	VNSSS	DEG_SPOP_SBC_1	342:346	Mutation rewiring degron network	0.1389
p.P275S	TCGA-A5-A0G1	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	268:272	Mutation rewiring degron network	0.25
p.E276A	TCGA-AM-5821	COAD	TCGA	PRSSS	DEG_SPOP_SBC_1	268:272	Mutation blocking phosphorylation signal	0.6667
p.R281H	TCGA-BG-A221	UCEC	TCGA	PRSSS	DEG_SPOP_SBC_1	268:272	Mutation rewiring degron network	0.0833
p.E348D	TCGA-EO-A22R	UCEC	TCGA	VNSSS	DEG_SPOP_SBC_1	342:346	Mutation rewiring degron network	0.2778
p.G338D	TCGA-NH-A5IV	COAD	TCGA	VNSSS	DEG_SPOP_SBC_1	342:346	Mutation rewiring degron network	0.2222
p.G350D	DO49095	COAD	ICGC	VNSSS	DEG_SPOP_SBC_1	342:346	Mutation rewiring degron network	0.2222
p.H265P	DO228105	EOPC	ICGC	PRSSS	DEG_SPOP_SBC_1	268:272	Mutation rewiring degron network	0.25
p.H265P	DO229173	THCA	ICGC	PRSSS	DEG_SPOP_SBC_1	268:272	Mutation rewiring degron network	0.25
p.H265P	DO229192	THCA	ICGC	PRSSS	DEG_SPOP_SBC_1	268:272	Mutation rewiring degron network	0.25
p.H265P	DO229087	THCA	ICGC	PRSSS	DEG_SPOP_SBC_1	268:272	Mutation rewiring degron network	0.25
p.H265P	DO229089	THCA	ICGC	PRSSS	DEG_SPOP_SBC_1	268:272	Mutation rewiring degron network	0.25
p.R338H	DO234216	ESAD	ICGC	VNSSS	DEG_SPOP_SBC_1	342:346	Mutation rewiring degron network	0.2222
p.D19G	DO23537	LIRI	ICGC	PGTTT	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.0556
p.R269P	DO23610	LUAD	ICGC	PRSSS	DEG_SPOP_SBC_1	268:272	Mutation altering degron motif	0.6401
p.R258C	DO37911	SKCM	ICGC	PRSSS	DEG_SPOP_SBC_1	268:272	Mutation rewiring degron network	0.0556
p.R258C	ACH-000556	Cervical Cancer	CCLE	PRSSS	DEG_SPOP_SBC_1	268:272	Mutation rewiring degron network	0.0556
p.R258C	SiHa	cervix	COSMIC	PRSSS	DEG_SPOP_SBC_1	268:272	Mutation rewiring degron network	0.0556
p.R258H	DO222342	STAD	ICGC	PRSSS	DEG_SPOP_SBC_1	268:272	Mutation rewiring degron network	0.0556
p.R258H	DO52399	UCEC	ICGC	PRSSS	DEG_SPOP_SBC_1	268:272	Mutation rewiring degron network	0.0556
p.V342A	DO229268	THCA	ICGC	VNSSS	DEG_SPOP_SBC_1	342:346	Mutation altering degron motif	0.5825
p.E337D	DO42713	UCEC	ICGC	VNSSS	DEG_SPOP_SBC_1	342:346	Mutation rewiring degron network	0.1944
p.R271H	SIDM00068	Colorectal Carcinoma	GDSC	PRSSS	DEG_SPOP_SBC_1	268:272	Mutation altering degron motif	0.8244
p.R271H	GEO	large intestine	COSMIC	PRSSS	DEG_SPOP_SBC_1	268:272	Mutation altering degron motif	0.8244
p.I43S	ACH-001991	Primary	CCLE	PGTTT	DEG_SPOP_SBC_1	29:33	Mutation rewiring degron network	0.0556
p.R338L	WM278	skin	COSMIC	VNSSS	DEG_SPOP_SBC_1	342:346	Mutation rewiring degron network	0.2222
p.R260H	GEO	large intestine	COSMIC	PRSSS	DEG_SPOP_SBC_1	268:272	Mutation rewiring degron network	0.1111
p.P277S	A253	salivary gland	COSMIC	PRSSS	DEG_SPOP_SBC_1	268:272	Mutation rewiring degron network	0.1944

Kaplan plot for ATAT1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ATAT1

UniProt ID: Q5SQI0

Entrez ID: 79969

Protein name: Alpha-tubulin N-acetyltransferase 1 (Alpha-TAT) (Alpha-TAT1) (TAT) (EC 2.3.1.108) (Acetyltransferase mec-17 homolog)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ATAT1 in