DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
PGTTT
Uniprot ID:
Q5SQI0
Source protein:
Alpha-tubulin N-acetyltransferase 1
Source gene:
ATAT1
Class:
DEG_SPOP_SBC_1
Location:
29:33
E3 ligase:
SPOP
DEGRON score:
0.5329
ASA_SCORE:
68.6
COIL:
0.9272
CONS_SCORE:
0.2587
DSS_SCORE:
0.6408
HELIX:
0.0318
FCONS_SCORE:
0.7813
RIG_SCORE:
0.6578
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.D19G
DO23537
LIRI
ICGC
PGTTT
DEG_SPOP_SBC_1
0.0556
p.I43S
ACH-001991
Primary
CCLE
PGTTT
DEG_SPOP_SBC_1
0.0556
Drug responses associated with ATAT1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PGTTT
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O00592
Podocalyxin
DEG_SPOP_SBC_1
90:94
PGTTT
SPOP
0.9852
More...
O15054
Lysine-specific demethylase 6B
DEG_SPOP_SBC_1
394:398
PGTTT
SPOP
0.9903
More...
O75150
E3 ubiquitin-protein ligase BRE1B
DEG_SPOP_SBC_1
568:572
PGTTT
SPOP
0.8754
More...
P51610
Host cell factor 1
DEG_SPOP_SBC_1
584:588
PGTTT
SPOP
0.6872
More...
P51610
Host cell factor 1
DEG_SPOP_SBC_1
763:767
PGTTT
SPOP
0.9496
More...
Q13642
Four and a half LIM domains protein 1
DEG_SPOP_SBC_1
311:315
PGTTT
SPOP
0.8812
More...
Q5SQI0
Alpha-tubulin N-acetyltransferase 1
DEG_SPOP_SBC_1
29:33
PGTTT
SPOP
0.5329
More...
Q9HC84
Mucin-5B
DEG_SPOP_SBC_1
1498:1502
PGTTT
SPOP
0.9082
More...
Q9HC84
Mucin-5B
DEG_SPOP_SBC_1
2268:2272
PGTTT
SPOP
0.9849
More...
Q9HC84
Mucin-5B
DEG_SPOP_SBC_1
2825:2829
PGTTT
SPOP
0.8413
More...
Q9HC84
Mucin-5B
DEG_SPOP_SBC_1
3525:3529
PGTTT
SPOP
0.9452
More...
Q9HC84
Mucin-5B
DEG_SPOP_SBC_1
4082:4086
PGTTT
SPOP
0.9542
More...
Q96MZ4
Protein FAM218A
DEG_SPOP_SBC_1
63:67
PGTTT
SPOP
0.8498
More...